Diindolylmethane (DIM) and Calcium D- Glucarate (CDG)

Recently, a variety of combination supplements containing both Diindolylmethane (DIM) and Calcium D- Glucarate (CDG) have become commercially available. The combined use of DIM and CDG can effectively balance hormone levels in the body.

Healthkintai^®, as a major manufacturer of DIM powder, can provide you with high-quality ≥99% DIM powder. If you require it, please feel free to contact us at health@kintaibio.com.

What Is the Difference between DIM and Calcium D-Glucarate (CDG)?

DIM

DIM, derived from cruciferous vegetables like broccoli and kale, optimizes estrogen metabolism. People would need to consume large quantities of these vegetables to match clinical doses, but DIM supplements offer a practical solution.

The primary benefit of DIM lies in its ability to promote the production of beneficial, protective 2-hydroxy metabolites while reducing the generation of the unfavorable, reactive, and inflammatory metabolites mentioned above. As a result, the overall estrogenic activity in the body is decreased, leading to a reduction in associated inflammation and the tendency for unwanted cell division. In doing so, DIM also helps counteract estrogen dominance.

Calcium D-Glucarate (CDG)

CDG is a natural substance made from glucaric acid, which can be found in small amounts in fruits and vegetables such as oranges, apples and cruciferous vegetables.

It supports the liver’s detoxification pathways and assists in eliminating harmful substances, including toxins and excess hormones, particularly estrogen. Its mechanism of action lies in inhibiting the enzyme beta-glucuronidase. This enzyme is produced by gut bacteria and can break the bond between toxins and glucuronic acid, leading to the reabsorption of toxins into the body. By inhibiting beta-glucuronidase, CDG helps prevent the reabsorption of these toxins and promotes their excretion.

What Is the Purpose of Combining DIM and Calcium D-Glucarate (CDG)?

Estrogen dominance has become an invisible force undermining the health of both sexes. Its impact is pervasive—from women’s menstrual discomfort and mood swings to men’s energy depletion and body shape changes. The combination of DIM and CDG has been shown to effectively counteract estrogen dominance. What are the causes of estrogen dominance?

First, the pervasive presence of environmental estrogens (e.g., from plastics and pesticides) in modern life, combined with obesity (as fat cells produce estrogen), increases the body’s overall estrogen load from both external and internal sources.

Then, if the liver’s metabolic capacity is compromised due to nutritional deficiencies or toxin overload, it becomes inefficient at converting active estrogen into safe metabolites and preparing them for elimination.

Most critically, during intestinal excretion, if gut dysbiosis or constipation exists, the enzyme beta-glucuronidase can reactivate the estrogen already processed by the liver, allowing it to be reabsorbed back into the body.

How Do DIM and Calcium D-Glucarate (CDG) Work Together?

The Process of the Liver Metabolizing Estrogen

The liver serves as the core processing plant for estrogen metabolism in the human body, a process that primarily involves two precisely coordinated phases: Phase 1 and Phase 2.

In the first phase, the liver converts active estrogen into three metabolites through hydroxylation—2-hydroxyestrone is a protective “good” metabolite that counteracts strong estrogen effects, while 16α-hydroxyestrone and 4-hydroxyestrone are “bad” metabolites that promote estrogen dominance.

In the second phase, the liver tags these metabolites as “waste” via conjugation, rendering them inactive and water-soluble, ready to be excreted through bile into the intestines.

 

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The Synergistic Process of DIM and Calcium D-Glucarate (CDG)

There is a hidden risk that lies in the final excretion step: if gut microbiota is imbalanced, beta-glucuronidase can remove these tags, reactivating estrogen and allowing it to be reabsorbed into the bloodstream—a process known as enterohepatic circulation. Therefore, complete estrogen metabolism requires not only the liver to produce more beneficial metabolites (supported by DIM supplementation) and efficiently complete phase two packaging but also relies on smooth intestinal excretion (aided by CDG to inhibit beta-glucuronidase). A failure in any of these steps can lead to estrogen accumulation and imbalance.

By combining DIM and CDG, a comprehensive defensive system against estrogen accumulation can be established, covering both prevention and clearance. CDG works in the gut to block the enzyme beta-glucuronidase, which would otherwise allow estrogen to re-enter circulation, thereby ensuring its elimination from the body. Meanwhile, DIM acts upstream in the liver, converting estrogen into less harmful forms. This “one-two punch” supports long-term hormonal balance, reduces inflammation risks, and can be seamlessly integrated into daily routines focused on vitality and preventive wellness.

Potential Benefits and Risks of the Combined Use of DIM and Calcium D-Glucarate (CDG)

Potential Benefits	Potential Risks
Dual action effectively eliminates excess estrogen: DIM promotes the conversion of estrogen into protective metabolites in the liver, while CDG blocks intestinal enzymes to prevent reabsorption, jointly optimizing the hormone detoxification pathway.	Mild gastrointestinal discomfort: e.g., bloating. Both may irritate the intestinal lining at high doses; CDG affects intestinal enzymes, while DIM may temporarily slow down digestion, but relief usually comes quickly.
Supports synergistic liver and intestinal detoxification: CDG enhances the “conjugation” effect of phase II liver detoxification to facilitate toxin excretion, while DIM balances estrogen breakdown, jointly improving overall detoxification capacity.	Rare headaches or fatigue may occur initially: The hormone-altering effect of DIM may cause adaptation symptoms during the normalization of estrogen levels; CDG rarely causes this issue, but sensitive individuals may experience exacerbated reactions.
Promotes hormonal balance and boosts vitality: By promoting “favorable” estrogen and aiding its excretion, this combination can reduce estrogen dominance symptoms, supporting mood, energy, and reproductive health through complementary mechanisms.

Why Should You Buy DIM Powder Produced by Healthkintai^®?

Healthkintai^® is a professional manufacturer of DIM powder. We specialize in manufacturing DIM powder with a purity of 99%.

Manufactured under strict manufacturing and quality standards, our DIM ensures superior consistent quality, high density, and stability. In the world of dietary supplements, DIM has been gaining popularity for its potential health benefits. Our DIM is compliant with global standards for commercial bulk distribution and widely used in pharmaceuticals, nutraceuticals, and dietary supplements.

If you want to produce DIM supplements, please feel free to contact us at health@kintaibio.com to order our DIM powder.