3,3’-Diindolylmethane Powder

3,3'-Diindolylmethane (DIM) Manufacturer

Healthkintai^® is specialized in manufacturing 3,3’-Diindolylmethane, mainly producing ≥99% diindolylmethane powder. We synthesize diindolylmethane through acid-catalyzed reactions. The core process involves the condensation of indole with carbonyl sources (most commonly formaldehyde or aldehydes). You can choose it to make some supplements. If you require high-quality ≥99% diindolylmethane powder, please feel free to contact us at health@kintaibio.com.

What is 3,3’-Diindolylmethane?

3,3’-Diindolylmethane is a powerful phytonutrient derived from cruciferous vegetables that functions primarily by optimizing the body’s estrogen metabolism. It is regarded as an effective hormonal balancer and has shown significant potential in supporting cancer prevention, improving skin health, and maintaining overall hormonal equilibrium.

 Although the human body can produce DIM, it must consume sufficient amounts of indole-3-carbinol-rich vegetables through the diet and rely on the assistance of stomach acid for conversion. The body itself cannot synthesize DIM out of nothing. Therefore, plant tissues contain virtually no natural DIM. While increasing intake of vegetables such as broccoli is always beneficial, for individuals with specific health needs, highly bioavailable DIM supplements may offer a more direct and effective option.

The Technical Data Sheet (TDS) of 3,3’-Diindolylmethane (DIM) Powder

Regulatory Status of 3,3’-Diindolylmethane(DIM)

In the European Union

DIM does not have a specific regulatory approval as a novel food ingredient in the European Union, so it cannot be legally sold in food products there.

In New Zealand

It is not approved as a standalone chemical but can be used as a component in products covered by a group standard. Separately, DIM is a subject of scientific research for potential medicinal applications, but it is not an approved drug. 

FDA

DIM is regulated under the Dietary Supplement Health and Education Act of 1994, which places the responsibility on manufacturers to ensure the product is safe and its labeling is truthful and not misleading.

3,3’-Diindolylmethane (DIM) Benefits for Women

The female reproductive system is profoundly influenced by environmental changes, genetic factors, the aging process, and hormonal levels. Hormonal imbalances can lead to irregular menstrual cycles or polycystic ovary syndrome. Specifically, an imbalance in estrogen not only contributes to issues like weight gain and difficulty losing weight but also increases the risk of developing malignant breast cells. Furthermore, many women entering menopause face challenges such as hot flashes, night sweats, mood swings, and irritability due to the significant shifts in their hormonal levels. So what does diindolylmethane do for women?

Modulating estrogen metabolism effect

DIM modulates the process of estrogen metabolism, promoting the production of substances with anti-inflammatory and anti-carcinogenic properties. Specifically, DIM elevates levels of the weak estrogen metabolite 2-hydroxyestrone, which is considered to possess cancer-preventive potential, while suppressing the generation of more potent estrogen metabolites—such as 4-hydroxyestrone and 16α-hydroxyestrone—that may promote cancer development. Research indicates that the shift in the ratio of 2-hydroxyestrone to 16α-hydroxyestrone induced by DIM may be associated with a reduced risk of certain cancers.

Antioxidant and anti-inflammatory effects

Research has confirmed that DIM powder can activate the body’s endogenous antioxidant system, including upregulating the activity of the key endogenous antioxidant enzyme superoxide dismutase. Additional studies indicate that DIM can elevate levels of glutathione, one of the body’s most potent antioxidants. Through these direct and indirect antioxidant mechanisms, DIM helps protect cells from free radical damage.These antioxidant properties make DIM particularly promising in fields such as skin health and anti-aging. Studies show that topical application of DIM can reduce oxidative stress in skin cells, thereby helping to delay collagen degradation associated with aging.

DIM exerts its anti-inflammatory effects by suppressing the activation of the key inflammatory signaling pathway, nuclear factor-kappa B (NF-κB), thereby modulating the inflammatory response at an upstream level. Further studies demonstrate that DIM significantly reduces the release of multiple inflammatory mediators, including nitric oxide (NO), prostaglandin E₂ (PGE₂), as well as critical cytokines such as interleukin-6 (IL-6) and IL-1β. Moreover, DIM inhibits the expression of inflammation-related proteins including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), demonstrating its multi-faceted anti-inflammatory activity.

Healthkintai^®’s ≥99% DIM is a key ingredient born for women’s health supplements. It is dedicated to safeguarding the radiance and vitality of modern women by addressing the root cause—hormonal balance.

3,3’-Diindolylmethane (DIM) Benefits for Men

Optimizing the testosterone level effect

DIM aids the body in optimizing testosterone levels. Testosterone is an androgen responsible for regulating and defining male characteristics, such as the development of reproductive organs, deepening of the voice, and body hair distribution. It is also an anabolic hormone that promotes protein synthesis, thereby supporting muscle growth and bone strength. In addition, testosterone serves as the primary regulator of sperm production in adult men. Supplementing with DIM can be highly beneficial for men, as it helps free up bound testosterone and enhances its efficacy within the body.

Prostate protection effect

The core benefit of DIM for male prostate health lies in its dual protective mechanisms. Primarily, it precisely regulates estrogen metabolism, directing the body to produce harmless estrogen metabolites. This reduces abnormal stimulation of prostate tissue and maintains hormonal balance.

More importantly, DIM demonstrates potent anti-cancer potential: it inhibits cancer cell proliferation, induces apoptosis (programmed cell death), and may slow the progression of precancerous lesions such as prostatic intraepithelial neoplasia (PIN). Combined with its anti-inflammatory and antioxidant properties, DIM establishes a robust defense for prostate health through multiple pathways, making it particularly suitable for men focused on long-term prostate wellness as part of an active health management strategy.

Healthkintai^®, a leading producer of high-purity DIM, now introduces a strategic raw material specifically engineered for men’s health supplements. It is designed to empower brands in developing the new generation of men’s health products.

The Potential Benefits of 3,3’-Diindolylmethane(DIM) against Liver Cancer

DIM demonstrates potential in suppressing hepatocellular carcinoma (HCC) by inhibiting cancer cell proliferation, migration, and invasion. It functions primarily through inducing apoptosis (programmed cell death) and disrupting key signaling pathways such as the FAK pathway. Research indicates that DIM’s anti-cancer efficacy observed in cell line studies is dose-dependent, suggesting its promise as a potential therapeutic agent.

3,3’-Diindolylmethane (DIM) Dosage and Contraindications

Dosage of DIM

DIM is generally available as 100–200mg capsules. Since detox-related symptoms may occur, it is recommended to start with a low dose: take 100mg daily or every other day until detox symptoms subside, then maintain or increase the dose based on your goals. Bodybuilders typically take 400mg daily when using DIM to counteract the conversion of testosterone supplements to estrogen. Patients supplementing with DIM for cancer intervention usually require higher doses. Regardless of the intended effect of DIM supplementation, it is advised to use it under the guidance and supervision of a healthcare professional.

Contraindications of DIM

1. Avoid use if you are trying to conceive, pregnant, or breastfeeding.

2. Avoid use if you have hormone-related diseases (e.g., breast cancer, cervical cancer, ovarian cancer, endometriosis, uterine fibroids, etc.).

3. High-dose use (over 300mg) may cause hyponatremia symptoms, which can adversely affect cognition, balance, and attention.

4. Do not use concurrently with diuretics, as this may lower blood sodium levels.

5. Do not use concurrently with hormone replacement therapy (HRT), as it may reduce the effectiveness of the medication.

6. Do not use concurrently with cytochrome P450 enzymes.

7. Individuals with liver or kidney disease should consult a healthcare provider before use.

The Side Effects of 3,3’-Diindolylmethane (DIM)

DIM is generally safe when consumed in small amounts through food (daily intake of 2-24 mg). Short-term medicinal use at recommended doses is likely safe for most people, but higher doses such as 600 mg per day may pose risks such as hyponatremia.

Pregnant or breastfeeding women and children are advised to obtain DIM only through dietary sources. Individuals with hormone-sensitive conditions (e.g., breast cancer, uterine fibroids) should avoid DIM supplementation due to its dual-directional modulation of estrogen activity, despite its potential protective effects.

Reported side effects are generally mild and transient, including cases of urine discoloration, gastrointestinal discomfort, rash, headache, and visual disturbances.

Where Can You Buy 3,3’-Diindolylmethane (DIM)?

1.Our production facilities hold internationally recognized certifications,such as GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and and HALAL.

2. “Efficacy Begins with Purity” — We firmly believe that only the purest raw materials can deliver the   most reassuring results.

3. Ultra-High Purity, 99%+ Specification: Every batch of our DIM powder strictly meets a purity standard of over 99%. This means you receive an essence component virtually free of impurities, ensuring both the safety and high efficacy of the final product.

4. Superior Craftsmanship and Quality: Utilizing advanced synthesis and multiple purification technologies (such as recrystallization), we ensure our product boasts high crystallinity, excellent stability, and consistent batch-to-batch quality. This provides downstream brands with the most reliable raw material guarantee.

5. Scientifically Backed, Trustworthy: Our product specifications meet the requirements of high-end health supplements and scientific research. Its purity and physicochemical properties are verified by third-party testing, serving as a solid foundation for your product development and marketing efforts.

If you want to order high-quality ≥99% diindolylmethane powder, please feel free to contact us at health@kintaibio.com.

FAQ

1. Does DIM reduce belly fat?

Most investigations into DIM’s effects on weight loss have been limited to animal studies, with human clinical evidence remaining insufficient. However, existing research suggests DIM supplementation may promote fat breakdown and prevent adipocyte formation. Human studies have confirmed that estrogen imbalance significantly increases the risk of weight gain.

2. Why do bodybuilders take DIM?

DIM indirectly supports muscle growth by balancing estrogen and testosterone levels. Testosterone is crucial for enhancing muscle strength and endurance, while estrogen synergizes with exercise to increase lean body mass. This hormonal regulation helps optimize exercise performance and bodybuilding outcomes.

3. When to take DIM morning or night?

Take DIM with food, ideally in the morning, to improve absorption and maintain consistent levels. Some individuals find taking it at night beneficial for sleep-related issues, while dividing the daily dose between morning and night can also work to keep levels steady throughout the day.

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