Myo-Inositol and D-Chiro-Inositol

In the intricate metabolic network of the human body, Myo-inositol (MI) and D-chiro-inositol (DCI) are not mere substitutes but a pair of functionally complementary “metabolic partners” that require precise synergy. MI acts as a comprehensive coordinator, broadly supporting cellular signalling and ovarian function, while our DCI serves as a precision metabolic regulator, specifically focused on optimising insulin pathways and glucolipid metabolism. Under physiological conditions, the two maintain a dynamic balance, working together to support women’s reproductive and metabolic health.

Healthkintai^® is a major manufacturer of DCI powder in China. It is precisely based on this deep understanding of these “precision partners” that we are committed to producing high-quality DCI.

If you want to order DCI Powder (95%, 98%, and 99% specifications are available), please feel free to contact us at health@kintaibio.com.

What Is the Difference between Myo-Inositol and D-Chiro-Inositol?

Inositol is a polyalcohol with the formula C₆H₁₂O₆ that exists in the form of nine stereoisomers. Stereoisomers are naturally occurring molecules that share the same molecular formula but differ in chemical and physical properties. These nine different isomers are found in plasma lipoproteins, phospholipids of cell membranes, and as phosphate salts within the cell nucleus.

Although the two stereoisomers, MI and DCI, appear nearly identical, it is precisely this subtle structural difference that enables them to play distinct roles in insulin signaling pathways and other physiological functions in the human body.

The Benefits of Myo-Inositol and D-Chiro-Inositol on PCOS

The efficacy of MI and DCI combination therapy for Polycystic Ovary Syndrome (PCOS) is based on their complementary and synergistic mechanisms of action within the body, particularly in restoring ovarian function, improving insulin resistance, and regulating hormonal balance.

Their core mechanisms of action differ, and combining them allows for a more comprehensive approach to the pathophysiology of PCOS. The table below compares their key distinctions:

Property	Myo-Inositol (MI)	D-Chiro-Inositol (DCI)
Primary Action Focus	Improves ovarian function and follicular development	Modulates insulin signaling and glucose metabolism
Direct Impact on Hormone Synthesis	Inhibits androgen synthesis: Increases the expression of aromatase and FSH receptors, promoting the conversion of androgens to estrogens, thereby reducing androgen levels	Promotes androgen synthesis: Stimulates androgen production in ovarian theca cells
Role in Insulin Signaling Pathway	Acts upstream, participating in the transduction of insulin signals	Acts downstream, promoting glycogen synthesis and storage
Common Imbalance in PCOS Patients	Levels are insufficient in ovarian tissue	Levels are relatively excessive in ovarian tissue

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The Benefits of Myo-Inositol and D-Chiro-Inositol on Fertility

Improves Insulin Resistance
Women with PCOS often experience insulin resistance—the two conditions are closely linked. While women with PCOS can produce insulin, their bodies cannot use it effectively. If you have PCOS, improving insulin resistance will make the most significant difference, helping to reduce or eliminate various symptoms such as infertility, acne, and weight gain. Both MI and DCI have positive effects on insulin sensitivity. In particular, the ability of MI to reduce insulin resistance has been shown to lower testosterone levels. Lower testosterone levels help balance hormones, preventing the endocrine disruptions that lead to anovulation and thereby increasing the chances of pregnancy.

Improves Egg Quality
In addition to enhancing ovarian function, studies have shown that taking inositol supplements can improve oocyte quality. This is achieved by increasing the insulin sensitivity of the ovaries, which in turn enhances egg quality.

Reduces the Risk of Gestational Diabetes
PCOS is one of the risk factors for gestational diabetes. Gestational diabetes occurs during pregnancy due to glucose intolerance, meaning there is a higher risk of delivering a larger baby and experiencing preterm birth. Your baby is also more likely to have low blood sugar and an increased risk of developing type 2 diabetes in the future. Both MI and DCI can help reduce the risk of gestational diabetes by aiding in the regulation of glucose homeostasis.

Improves IVF Success Rates

Undergoing IVF treatment is mentally, physically, and emotionally draining, so any method that can support this process is worth considering. One such approach is taking a reputable inositol supplement, such as Inofolic Alpha Plus, to enhance IVF outcomes. Studies have shown that inositol supplements can reduce the required dosage of gonadotropins and shorten the duration of the IVF cycle. Another study found that inositol improves embryo quality and increases pregnancy rates among infertile women undergoing IVF.

Myo-Inositol and D-Chiro-Inositol Ratio

The ideal MI/DCI ratio for supplements, particularly for conditions like PCOS, is 40:1, reflecting the natural ratio found in the body’s plasma. This ratio is widely used in clinical studies and commercial products to improve insulin resistance, restore hormonal balance, and restore ovulation. Using this specific ratio is considered more effective than DCI alone and is designed to avoid the negative effects of excess DCI, which can impair egg quality.

Common dosages

A common dosage for a 40:1 ratio supplement is 2,000 mg of MI and 50 mg of DCI per day, which provides the 40:1 ratio.

Some products and recommendations suggest a higher range, such as 2000-4000 mg of MI and 50-100 mg of DCI per day.

It’s crucial to follow the specific instructions provided by your healthcare provider, as the optimal dosage can vary based on individual needs.

The Side Effects of Myo-Inositol and D-Chiro Inositol

Why Choose D-Chiro-Inositol from Healthkintai^®?

Healthkintai^® specialises in producing D-Chiro-Inositol powder. Our product advantages are as follows:

1. Leading Purity: Core Indicator

The purity of D-Chiro-Inositol can be up to ≥ 99%, verified by High-Performance Liquid Chromatography (HPLC). The product is free from impurities of other inositol isomers, meeting the requirements of high-demand scenarios such as pharmaceuticals and functional foods.

2. Strict Impurity Control

The content of heavy metals is ≤ 0.1 mg/kg, and the total microbial count is ≤ 100 CFU/g.

3. Physical Properties

Powder fineness: ≥ 90% through 80 mesh

High stability: Shelf life of 24 months under light-proof and sealed conditions

If you require D-Chiro-Inositol Powder with different specifications, please feel free to contact us at health@kintaibio.com.