Among functional ingredients, natural flavonoids have become a focal point for the B2B market. Myricitrin and myricetin,a dynamic duo derived from plants of the Myricaceae family with closely related chemical structures,are opening up new possibilities for dietary supplements, functional foods, and high-end skincare products thanks to their distinct molecular characteristics. Myricitrin, existing as a glycoside, offers superior sustained-release properties and stability, while its aglycone counterpart, myricetin, stands out for its high bioavailability and efficacy in antioxidant and anti-inflammatory applications; used synergistically, the two meet multifaceted formulation needs ranging from oral anti-aging solutions to skin protection. Contact us at info@kintaibio.com.
What is Myricitrin?
In terms of functional properties, myricitrin powder exhibits multiple biological activities, including potent antioxidant, anti-inflammatory, and analgesic effects. Its antioxidant mechanism operates primarily through free radical scavenging and metal ion chelation; numerous studies indicate that its activity surpasses that of certain common flavonol glycosides. Regarding applications, due to its natural origin and favorable safety profile, myricitrin is increasingly being incorporated into the formulations of dietary supplements, functional foods, and anti-aging skincare products.
Myricitrin is a natural flavonol glycoside with the chemical formula C₂₁H₂₀O₁₂ and CAS number 17912-87-7. Its molecular structure consists of myricetin linked to a rhamnose molecule via a glycosidic bond. Primarily found in the fruits, bark, and leaves of plants in the Myricaceae family, it serves as a plant secondary metabolite that functions in antioxidant defense.
What does Myricitrin do?
The mechanisms underlying the multiple biological activities of myricitrin involve coordinated regulation at various molecular levels. Regarding antioxidant effects, myricitrin powder effectively mitigates oxidative stress-induced damage to tissues such as the vascular endothelium by directly scavenging reactive oxygen species (ROS), reducing lipid peroxide levels, and enhancing the activity of endogenous antioxidant enzymes like superoxide dismutase (SOD). In terms of anti-inflammatory activity, the mechanism is closely linked to the inhibition of NF-κB inflammatory signaling pathway activation and the downregulation of pro-inflammatory cytokines, such as TNF-α and MCP-1.
Regarding cellular protection, bulk myricitrin significantly upregulates the expression of the anti-apoptotic protein Bcl-2 while downregulating the pro-apoptotic protein Bax and inhibiting the activation of Caspase-3, a key executioner enzyme of apoptosis; by modulating the Bcl-2/Bax ratio and suppressing p53 gene expression as well as phosphorylation within the MAPK signaling pathway, it effectively blocks the apoptotic cascade.Furthermore, the inhibitory effect of myricitrin on α-glucosidase activity (IC50 = 80.37 mg·L⁻¹)-which delays carbohydrate absorption through mixed-type inhibition-is one of the mechanisms by which it helps regulate blood glucose levels.
What is Myricetin?
Myricetin powder is a natural flavonol compound with the chemical formula C₁₅H₁₀O₈ and CAS number 529-44-2. Structurally based on the flavonol skeleton and containing five phenolic hydroxyl groups, it serves as the aglycone form of myricitrin. This compound is widely distributed in the fruits of plants in the Myricaceae family, as well as in tea, vegetables, and various medicinal plants; it is particularly abundant in the fruit and root bark of Chinese bayberry. Biologically, vine tea extract myricetin exhibits potent antioxidant activity-ranking among the most effective free-radical scavengers within the flavonoid class-alongside significant anti-inflammatory, antibacterial, antiviral, and antitumor pharmacological properties.
In terms of application, bulk myricetin wholesale offers distinct advantages regarding skin permeability and oral bioavailability due to its relatively low molecular weight and superior lipid solubility compared to its glycoside forms; consequently, it is widely researched for use in functional foods, dietary supplements, and anti-aging skincare products. When selecting raw materials, ensuring a high-purity (≥98%) and stable supply from botanical sources is a crucial prerequisite for realizing its full functional value.
How does Myricetin work?
Regarding its antioxidant activity, myricetin powder primarily functions by activating the Nrf2/HO-1 signaling pathway and upregulating the expression of endogenous antioxidant enzymes such as superoxide dismutase (SOD), while simultaneously scavenging reactive oxygen species (ROS) to effectively mitigate oxidative stress-induced damage. Its anti-inflammatory mechanism centers on inhibiting the activation of the NF-κB inflammatory signaling pathway and downregulating the expression of pro-inflammatory cytokines-such as TNF-α and IL-6-while also blocking the phosphorylation of MAPK pathways (including JNK and p38). In terms of anti-tumor effects, bulk myricetin inhibits tumor cell proliferation, induces apoptosis, and suppresses angiogenesis by interfering with multiple signaling pathways, including PI3K/AKT, WNT, and JNK.
Is Myricitrin and Myricetin the same?
Although myricitrin and myricetin are structurally closely related and both belong to the class of flavonoids, they exhibit significant differences in molecular composition, physicochemical properties, and biological activity. The presence of a glycosyl group gives myricitrin a higher molecular weight and superior water solubility compared to myricetin, though its lipid solubility is relatively lower; conversely, myricetin, with its lower molecular weight and higher proportion of phenolic hydroxyl groups, possesses better lipid solubility. Furthermore, their metabolic pathways in the body differ: myricitrin requires enzymatic deglycosylation in the intestine to be converted into its active aglycone form before absorption, whereas myricetin can enter metabolic processes directly.
Regarding applications, myricitrin attracts greater interest in the functional food and oral supplement sectors due to its sustained-release characteristics and stability advantages. In contrast, myricetin, valued for its high bioavailability and potent free-radical scavenging capabilities, holds greater research potential for transdermal skincare products and targeted delivery systems. Consequently, formulation design requires a differentiated approach based on the intended efficacy and the specific characteristics of the dosage form.
Myricitrin and Myricetin,which is better?
There is no absolute superiority between myricitrin and myricetin; the choice depends on matching the specific application scenario with the required dosage form. As a glycoside, myricitrin possesses a more stable structure, offering greater resistance to oxidative degradation during processing and storage. It requires hydrolysis by gut microbiota into myricetin before absorption can occur; this sustained-release mechanism helps prolong its duration of action and minimizes fluctuations in plasma concentration. Consequently, myricitrin offers distinct advantages for oral products such as dietary supplements and solid beverages due to its stability and sustained-release properties.
In contrast, myricetin-characterized by a lower molecular weight and superior lipophilicity, can enter metabolic pathways directly without enzymatic hydrolysis, resulting in a faster rate of oral absorption. In transdermal skincare products (such as serums and lotions), its excellent skin permeability allows the active ingredient to reach target skin layers more effectively; combined with potent free-radical scavenging capabilities, this makes it well-suited for antioxidant and anti-aging skincare formulations.
Where to buy the best Myricitrin and Myricetin powder?
Healthkintai® offers derived from bayberry bark extract and vine tea extract, both of which possess significant pharmacological potential-including antioxidant, anti-inflammatory, antimicrobial, and anti-tumor properties. The vine tea extract is refined using a proprietary process and is rich in active flavonoids such as dihydromyricetin, myricetin, and myricitrin, excelling in anti-inflammatory, antioxidant, and metabolic regulation applications. Both products feature transparent, traceable supply chains and rigorous quality control systems, with customization available for specifications; whether for functional foods, dietary supplements, or anti-aging skincare formulations, they provide a distinctive competitive edge for your products. Contact us at info@kintaibio.com.
