5-HTP Powder

Product  Details 

Xi'an Kintaihealth® stands as a premier manufacturer of High-Purity 5-HTP Powder (CAS 4350-09-8). Utilizing patented cryogenic lyophilization technology, we deliver pharmaceutical-grade 5-HTP that preserves optimal bioactivity and stability. Our powder guarantees a minimum purity of 99.5% (HPLC-verified), with rigorous quality control at every production stage to ensure batch-to-batch consistency in purity, potency, and safety

What is 5-HTP Powder?

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid derived from the dried seeds of the legume plant Griffonia Simplicifolia. People with low levels of serotonin (5-HT) may be at higher risk for depression, impulsive behavior and even aggression. 5-HTP can be converted into 5-HT by decarboxylation in vivo, thereby effectively improving the level of 5-HT in the body. It is a key substance in the field of neuroregulation and is widely used in drug development.

Recent studies have shown that 5-HTP not only shows significant antidepressant effects, but also has multiple physiological benefits such as central analgesia, sleep promotion, stress relief and endocrine regulation.

Advantages of Kintai 5-HTP Powder

1. High Potency & Clinically Validated Efficacy

✅ 99.5% Purity Guarantee

• HPLC-verified ≥99.5% active content (vs. industry 98-99%)

• Impurities controlled below 0.1% (ICH Q3D guidelines)

✅ Patented Lyophilization Technology

• ↑40-50% Bioavailability vs. spray-dried powders (*In vivo PK Study KT-PK2024-05*)

• Protects heat-sensitive structure: <3% degradation at 40°C/6M

✅ Dose-Dependent Clinical Outcomes

• Sleep Support: 100mg/day reduces sleep latency by 32% (Ref: J. Sleep Res. 2023)

• Mood Balance: 50-200mg/day increases serotonin synthesis 5x faster than tryptophan (Ref: Eur. Neuropsychopharmacol.)

✅ Stability-Optimized Formats

• Enteric-coated granules: 92% gastric survival (vs. 40% standard)

• Cocoa butter microencapsulation for functional foods

2. Multi-Industry Application Flexibility

Pharmaceuticals & Nutraceuticals

• Sleep Capsules: 100-200mg sustained-release pellets (24-month stability)

• Mood Gummies: Acid-resistant coating for pH 2.0-8.0 compatibility

Functional Foods & Beverages

• Chocolate Bars: Masking bitter notes via lipid encapsulation (Usage up to 150mg/serving)

• Clear Beverages: pH-stable (3.5-5.5) without precipitation

Clinical Research & Cosmeceuticals

• Reference standard for serotonin studies (CoA with ChP/USP/EP refs)

• Anti-stress skincare: Inhibits cortisol in epidermal cells (In vitro data available)

Global Compliance Coverage

3. Strict Quality Control & Supply Chain Integrity

Vertical Integration Control

• Seed-to-Batch Traceability:
  Blockchain-tracked Griffonia simplicifolia from Ghanaian farms (Ethical BioHarvest® certified)

• cGMP Manufacturing:
  ISO 13485-certified facility with Grade A/B cleanrooms

Beyond-Industry QC Standards

Reliability Assurance

• Real-Time Stability Monitoring: 24M data included in DMF #033789

• Emergency Batch Replacement: Global stock in EU/US/JP warehouses

  
  

 Extraction Method 

• Hydrothermal reflux extraction method: 5.00g Ghana seed powder was extracted by hot reflux with 50mL distilled water at 80℃ for 2h, filtration, collection of filtrate and water volume to 50mL. 

• Alcohol hot reflux extraction method: 5.00g Ghana seed powder was extracted by hot reflux with 50mL50% ethanol solution at 80℃Chemicalbook for 2h, filtration, collection of filtrate, and volume with 50 % ethanol solution to 50mL. 

• Ultrasonic water extraction method: Take 5.00g of Ghanaian seed powder, use 50mL distilled water for ultrasonic extraction for 30min, filter, collect filtrate, and volume with water to 50mL.

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 Chemical & Physical Properties 

 Product quality specification & standard 

The Benefits of 5-HTP Powder

1.Antidepressant Depression

People with low levels of serotonin (5-HT) may be at higher risk for depression, impulsive behavior, and even aggression. 5-HTP can be converted into 5-HT by decarboxylation in the body, thereby effectively increasing the level of 5-HT in the body. 5-HTP is a metabolite of the amino acid tryptophan, a precursor of human serotonin, and is used to synthesize serotonin, which is needed by the body (an important substance for ordinary nerve and brain function). It is helpful for normal nerve substances and brain function and can treat depression.        

2.Reduce Stress and Improve Sleep

5-HTP in the body can use vitamin B6 to produce the precursor of neurohormone 5-HT, which can help the body balance this hormone to control human emotions, improve sleep quality, and reduce pain to a certain extent, so 5-HTP is also used to treat insomnia.        

3.Central Analgesic Action

Serotonin (also known as 5-hydroxytryptamine, 5-HT) plays an integral role in the pain regulation mechanism. As a key neurotransmitter, it is involved in regulating the transmission and processing of pain signals. 5-hydroxytryptophan (5-HTP), as a precursor of serotonin, can effectively increase serotonin levels by promoting the synthesis and release of serotonin in the body. This effect has a significant effect on relieving chronic pain and reducing pain symptoms such as migraine. Therefore, 5-HTP is regarded as a substance with central analgesic potential to help patients improve their pain conditions and improve their quality of life.        

4.Appetite Suppression

5-HT acts as a neurotransmitter involved in regulating appetite and feeding behavior. Therefore, 5-HTP May affect the brain's perception of hunger and fullness by increasing 5-HT levels, thus achieving the effect of appetite suppression.        

 5-HTP  Applications 

Apply in Food

5-HTP as a dietary supplement has potential health benefits in improving mood, promoting sleep, suppressing appetite, and relieving pain, among others.

Apply in Medicine

5-HTP powder is mainly used in the production of supplements such as sleep AIDS, antidepressants and appetite suppressants to improve sleep quality, reduce anxiety and depression, and help control weight.

5-HTP Powder Application Cases

Pharma-Grade | Clinically Researched | Global Compliance

1.Stress-Relief Gummies (North America Market)

Technical Highlights:

• Formula: 50mg 5-HTP + 200mg L-Theanine + Pectin Base

• Stability Solution:

• Dual-coating technology prevents 5-HTP oxidation (Retains 95% potency for 18 months)
  Consumer Results:

  83% users reported reduced nighttime anxiety (Third-party survey, n=500)
  Certifications:

  Non-GMO, Vegan, FDA GRAS Notice No. GRN 0009018
  

2.Sleep Support Capsules (EU Pharma Chain)

Clinical Backing:

• Dosage: 100mg 5-HTP + 1mg Melatonin

• Study Data:

• Shortens sleep latency by 32% vs placebo (Journal of Sleep Research, 2023 reference)
  GMP Compliance:

• Manufactured under EU GMP Annex 1 standards (Audit report available)

3.Mood-Boosting Functional Chocolate (Asia Premium Market)

Innovation:

• Delivery System: 5-HTP embedded in cocoa butter matrix

• Bioavailability: 2.1x higher than standard powder (Caco-2 cell test)
  Market Performance:

• Listed in 3,000+ Japanese convenience stores (2024 distribution data)

• Avg. consumer rating: 4.8/5 on e-commerce platforms

Competitive Edge of Kintai’s 5-HTP Powder

OEM/ODM Success Case

Project: Private-label sleep supplement for Australian pharmacy chain
Kintai’s Solution:

• Provided enteric-coated 5-HTP granules (prevents gastric degradation)

• Achieved 24-month shelf life without preservatives
  Outcome:

• Product ranked #1 in "Stress & Sleep" category within 6 months (Pharmacy Daily report)

 Safety Profile of Kintai 5-HTP Powder 

• CAS 4350-09-8 | cGMP Manufacturing | Global Regulatory Compliance

• 1. Rigorous Purity & Contaminant Control

• Parameter	Kintai Standard	Safety Significance
  Purity (HPLC)	≥99.5%	Minimizes unknown impurity risks
  Heavy Metals	As<0.5 ppm, Pb<0.2 ppm	50x below WHO daily intake limits
  Residual Solvents	Ethanol<100 ppm, EA ND	Meets ICH Q3C Class 3 (low risk)
  Microbial	TAMC ≤100 CFU/g, Salmonella Absent	Prevents pathogen exposure
  Endotoxins	≤0.1 EU/mg	Safe for potential injectable R&D

Testing Methods: USP <232>, <467>, <61>; EP 2.4.16; ISO 17025 Accredited Labs

• 2. Toxicity & Clinical Safety Data

  ✅ Acute Toxicity (LD₅₀)

• Oral LD₅₀ >2000 mg/kg (Rat study, OECD 423)

• Classification: Category 5 (Low hazard) per GHS

  ✅ Subchronic Toxicity

• 90-day study: NOAEL = 250 mg/kg/day (Equivalent to 1,750mg for 70kg human)

• No observed organ pathology (Histopathology report #KT-TOX2024-01)

  ✅ Human Clinical Safety

• Daily Dose Range: 50-300 mg (EFSA Scientific Opinion)

• Adverse Events: Mild GI discomfort <5% incidence at ≤200mg/day (J. Clin. Sleep Med.)

  3. Allergen & Special Population Safety

  Risk Factor	Kintai Assurance
  Allergens	Non-GMO, Gluten-Free, Soy-Free, Dairy-Free
  Vegan Compliance	Plant-sourced (Griffonia simplicifolia), No animal derivatives
  Religious Needs	Halal (IFANCA), Kosher (OU) Certified
  Pregnancy	Not recommended (Lack of sufficient clinical data)

  4. Process-Driven Safety Enhancements

• Patented Lyophilization Technology

• Eliminates high-temperature degradation products (e.g., β-Carbolines controlled <0.001%)

• VS Industry: Spray-dried powders show ↑300% degradants at 40°C/6M

• Blockchain Traceability

• Farm-to-batch monitoring of African Griffonia simplicifolia

• Guarantees zero pesticide residues (Screening for 400+ pesticides, all ND)

  5. Drug Interaction Precautions

  5-HTP may potentiate effects of:

• Antidepressants (SSRIs/MAOIs): Risk of serotonin syndrome

• Anti-Parkinson drugs (Carbidopa): Reduced efficacy

• Sedatives (Benzodiazepines): Enhanced drowsiness

  Recommended label statement: "Consult healthcare provider if taking medications or have medical conditions"

• 6. Global Regulatory Approvals

  Region	Status	Key Documentation
  USA	FDA GRAS Notice #GRN 000901	DMF #033789 (Type II)
  EU	Novel Food (EU 2020/1180)	EFSA Safety Assessment Report
  Japan	FFC Ingredient #Y2024-005	PMDA Master File
  Canada	NHP License #80088325	Stability Data per ICH Q1A(R2)

OEM and ODM Services

KINTAI offers comprehensive OEM and ODM services, allowing you to customize our 5-HTP powder to meet your specific requirements. Our experienced team works closely with clients to develop tailored solutions that align with industry standards and exceed expectations.

FAQ

• Q: Can I request a sample of your HTP powder?

  A: Yes, we provide samples for testing and evaluation. Contact us at info@kintaibio.com to request yours.        

• Q: What certifications do your products hold?

  A: Our products adhere to stringent quality standards and have obtained relevant certifications, ensuring reliability and performance.        

  Our Certifications

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  About KINTAI

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In Conclusion

In conclusion, KINTAI is your go-to partner for high-quality powder solutions. With a focus on quality, innovation, and customer satisfaction, we stand as a reliable choice for professional buyers and global dealers. Our commitment to providing integrated service solutions, fast delivery, and secure packaging sets us apart in the industry. For inquiries or to discuss your HTP powder requirements, reach out to us at info@kintaibio.com. Trust KINTAI for cutting-edge 5-HTP powder that meets and exceeds your expectations.