Neohesperidin Dihydrochalcone (NHDC) in Skincare

Neohesperidin Dihydrochalcone (NHDC) exhibits the dual value of topical repair and oral conditioning in the skincare field. Its safety has been verified through in vitro experiments and human clinical trials, and it caters to core skincare needs such as anti-aging, sensitive skin repair, and basic moisturization. It can be widely applied in skincare products and oral beauty supplements.

Healthkintai^® has been focusing on supplying high-quality 98% Neohesperidin Dihydrochalcone (NHDC) powder, which can be added into many kinds of cosmetics. ​​​​​​​

If you are looking for a reliable 98% Neohesperidin Dihydrochalcone (NHDC) powder supplier, you can contact us at health@kintaibio.com. 

What is Neohesperidin Dihydrochalcone (NHDC)?

Neohesperidin Dihydrochalcone (NHDC) is a naturally derived functional ingredient, primarily extracted from citrus plants (e.g., the peels of bitter oranges and grapefruits). It is a hydrogenated derivative of neohesperidin, a natural flavonoid glycoside. Characterized by multiple phenolic hydroxyl groups (-OH) and glycosidic bonds in its molecular structure, this unique configuration not only endows it with core value in the food and dietary supplement sectors but also lays the foundation for its application in the skincare field. As a versatile ingredient that combines “sweetness modulation” and “bioactivity,” its safety has been validated by global authoritative institutions (JECFA, FDA, EFSA), making it widely suitable for food, dietary supplement, and skincare scenarios.

The Benefits of Neohesperidin Dihydrochalcone (NHDC) in Skincare

The skincare benefits of Neohesperidin Dihydrochalcone (NHDC) are primarily manifested in antioxidant activity, skin whitening and spot reduction, promotion of skin metabolism, and skin hydration, as detailed below:

Antioxidant Activity

As a flavonoid derivative, NHDC contains hesperidin groups that effectively scavenge free radicals in the skin, reducing oxidative damage and delaying the skin aging process. Its antioxidant activity protects skin cells from environmental stressors such as ultraviolet radiation and pollution, thereby maintaining skin health.

Skin Whitening and Spot Reduction

In vitro experiments demonstrate that NHDC exhibits significantly superior inhibitory effects on tyrosinase compared to common whitening agents. For instance, its IC50 value for tyrosinase inhibition is 82.02 µm/L, approximately twice that of vitamin C and 60 times that of β-arbutin. Human patch tests have also confirmed that a 2% NHDC gel achieves a total treatment effectiveness rate of 89.6% for melasma, with excellent safety and no irritation. This indicates that NHDC can effectively reduce pigmentation and improve uneven skin tone by inhibiting melanin production.

Promotion of Skin Metabolism

NHDC accelerates skin cell renewal, aiding in the removal of aged keratinocytes and leaving the skin smoother and more refined. This property helps maintain the skin barrier function and enhances the skin's resistance to external stimuli.

Skin Hydration

NHDC improves skin dryness and increases skin moisture content, keeping the skin soft and hydrated. Its moisturizing effect may be attributed to its ability to promote skin barrier repair and reduce water loss.

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The Applications of Neohesperidin Dihydrochalcone (NHDC) in Skincare

• It can be used in anti-aging skincare products (such as serums and creams) to help combat “photoaging” and “environmental aging” caused by UV radiation and pollution, reduce fine lines, and improve skin firmness.
• It is suitable for skincare products for sensitive skin (such as soothing serums and repair lotions) and acne-prone skin conditioning products, helping alleviate redness, itching, and inflammatory acne, as well as repair the damaged skin barrier.
• It can be used in basic moisturizing skincare products (such as moisturizing toners, lotions, and body lotions), especially suitable for dry skin and use in autumn and winter seasons, to enhance skin hydration and softness.
• It can be developed into “oral beauty supplements” (such as capsules and tablets), recommended for customers focusing on “internal conditioning and external care”—particularly for those in need of improving skin dryness and enhancing sun protection capability.

The Side Effects of Neohesperidin Dihydrochalcone (NHDC) in Skincare

Based on a comprehensive review of current scientific research and evaluations by authoritative bodies, a clear conclusion can be drawn: When used in skincare products in compliance with cosmetic regulations and at appropriate concentrations, NHDC is safe for topical application, with a very low risk of adverse reactions. The core safety information is clearly presented in the table below:

Scenario/Property	Safety Assessment	Key Information and Basis
Topical Skin Application (as a skincare ingredient)	Safe	The European Food Safety Authority (EFSA), in a 2025 assessment, explicitly stated that NHDC is non-irritating to the skin and is not a skin sensitizer. This indicates an extremely low likelihood of causing skin allergies or irritation under normal use conditions.
Oral Ingestion (as a food additive)	Safe within established limits	In a comprehensive re-evaluation in 2022, EFSA established an Acceptable Daily Intake (ADI) of 20 mg per kg of body weight for NHDC and confirmed no safety concerns at current usage levels.
Handling Raw Powder (in production or lab environments)	Inhalation risk requires caution	Some sources note that direct contact with or inhalation of high-purity (e.g., ≥20 ppm) NHDC powder may induce vomiting or migraines. However, this pertains to occupational exposure scenarios and is not relevant to consumer use of finished skincare products.

Where Can You Buy Neohesperidin Dihydrochalcone (NHDC)?

In the skincare application of Neohesperidin Dihydrochalcone (NHDC), whether it is used as an active ingredient in topical skincare products or a functional component in oral beauty supplements, the marketplace places extremely high demands on its quality standards. Healthkintai^® has a clear and profound understanding of this.

Our facilities hold internationally recognized certifications, such as GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL.

We have strict quality control. Purity Assurance: HPLC-verified ≥98% purity. 

If you require 98% Neohesperidin Dihydrochalcone (NHDC) powder, please feel free to contact us at health@kintaibio.com.