What is Hesperidin Diosmin used for?
2025-12-10 15:33:08
In today's global venous health market, which continues to expand at a scale, pharmaceutical companies and health supplement brands are facing a core challenge: how to find active ingredients that combine clinically authoritative endorsement, excellent safety, and a stable supply chain? Hesperidin and Diosmin are the key to winning market trust and creating blockbuster products.
Healthkintai® is a leading manufacturer and supplier of diosmin and hesperidin in China. If you require wholesale 90% diosmin and 98% hesperidin (other specifications can be customized), please contact us at info@kintaibio.com.
What is Hesperidin and Diosmin？
Are you looking for a natural cornerstone that provides multi-dimensional protection for your vascular system? Hesperidin, a flavonoid glycoside widely found in citrus peels, offers far more than just antioxidant benefits. As a powerful anti-inflammatory and capillary stabilizer (often referred to as the "vitamin P effect"), it acts as a 24/7 guardian, working to reduce vascular fragility and improve microcirculation. In your formulation, it's not only an indispensable base active ingredient but also a synergistic "enhancer," building the first line of defense for vascular health.
When the market calls for venous health products with a clear therapeutic focus, Diosmin is the answer. Primarily derived from hesperidin through biotransformation, it's a key driver for enhancing venous tone and promoting lymphatic drainage. Its mechanism of action directly targets the core pathological aspect of venous insufficiency—actively improving hemodynamics by strengthening venous wall contractility, effectively relieving edema and congestion. Choosing diosmin is like giving your product a powerful boost that directly improves circulation efficiency.
Hesperidin and diosmin compound formulation
Why do mainstream global products use a combination of 90% diosmin and 10% hesperidin? Because this is a choice made by both science and the market, and its synergistic logic is reflected on three levels.
First, in terms of efficacy, they form a defense-attack alliance. Hesperidin, as a powerful antioxidant and anti-inflammatory defender,clears away free radicals and inflammatory interference for diosmin, the forward agent that improves venous tone, working together to effectively reduce edema and tissue damage. During its journey through the body, hesperidin acts as a synergistic protector for diosmin. Studies show that hesperidin may significantly improve its bioavailability by inhibiting liver metabolic enzymes and slowing down the breakdown of diosmin, allowing each active ingredient to more effectively reach its target site.
This combination achieves a "multi-pronged approach" to venous insufficiency. They simultaneously act on four key pathological aspects: venous tone, capillary permeability, lymphatic return, and oxidative stress, forming an irreplaceable three-dimensional therapeutic network. This is the fundamental reason for its remarkable clinical efficacy and its status as the gold standard.
Hesperidin Diosmin Uses
This golden combination has extremely wide applications, spanning both the rigorous medical field and the booming health and wellness market.
1.Hesperidin Diosmin in pharmaceuticals
In core pharmaceuticals, they are the first-line standard treatment for chronic venous insufficiency (relieving leg heaviness, swelling, and pain) and acute hemorrhoid flare-ups, and are also frequently used for postoperative edema management, with efficacy validated through decades of clinical trials.
2.Hesperidin Diosmin Supplements
In the rapidly growing health products sector, their value is being explored in greater depth: as dietary supplements, they meet the daily circulatory health needs of sedentary individuals and pregnant women; integrated into functional foods and beverages, they serve the middle-aged and elderly, as well as specific occupational groups; and they are favored by high-end cosmetics and personal care products for improving microcirculation around the eyes, reducing redness, and providing antioxidant benefits, indicating a promising market prospect.
Diosmin Hesperidin Dosage
|
Purpose / Condition |
Typical Dosage (Diosmin/Hesperidin) |
Key Administration Notes |
|
Acute Symptom Treatment |
1000 mg/100 mg (MPFF) twice daily for the first 3-4 days. |
This is the standard loading dose for rapid relief of acute symptoms like pain, bleeding, and swelling. |
|
Maintenance Therapy |
1000 mg/100 mg (MPFF) once daily, or 500 mg/50 mg twice daily. |
Following the initial loading dose, therapy is continued at this maintenance level for weeks or months as directed. |
|
General Leg Health / Dietary Supplement |
500 mg/50 mg to 1000 mg/100 mg per day. |
Often found in OTC supplements for leg heaviness and circulatory support. Duration and dosage should follow product label or professional advice. |
|
Post-Surgical/Traumatic Edema Management |
1000 mg/100 mg twice daily, starting before surgery and continuing for several days after. |
Used prophylactically and therapeutically to reduce swelling. The regimen should be determined by a healthcare provider. |
What's the Side Effects of Diosmin Hesperidin？
Diosmin with hesperidin is generally well-tolerated by most individuals, with a safety profile supported by decades of clinical use. The most commonly reported side effects are mild and primarily related to the gastrointestinal system, such as abdominal discomfort, diarrhea, nausea, or bloating. These symptoms are typically transient and often resolve with continued use or by taking the supplement with food. In very rare cases, some individuals may experience headaches, dizziness, or skin reactions like rash or pruritus.
It is important to note that these compounds have minimal direct impact on heart rate or blood pressure, distinguishing them from stimulant-based supplements. However, as with any bioactive substance, consulting a healthcare professional before starting a new regimen is advisable, especially for pregnant or nursing women, individuals with severe liver conditions, or those taking other medications.
Why Choose KINTAI to buy Diosmin Hesperidin？
After gaining a deep understanding of the immense market potential of hesperidin and diosmin, choosing a reliable, professional, and empowering raw material partner is a crucial step in transforming your blueprint into a successful product. We sincerely recommend our products, which is not only a raw material but also a solid foundation for your product's competitiveness.
We first and foremost promise superior and consistent quality. We offer 98% hesperidin and 90% diosmin, precisely matching your different formulation designs and cost budgets. Our production system has obtained multiple international authoritative certifications, including GMP, ISO22000, and HACCP, ensuring that every step from production to delivery meets the highest global standards. Each batch of products comes with a detailed Certificate of Analysis (COA) quality inspection report, strictly controlling key indicators such as purity, heavy metals, microorganisms, and solvent residues, providing you with reliable certification.Feel free to contact us at info@kintaibio.com.
FAQ
Q1:Does diosmin really work for hemorrhoids?
A1:Yes, diosmin (especially in its micronized form combined with hesperidin) is clinically proven and widely recognized as a first-line pharmacological treatment for acute hemorrhoid flare-ups. It works by improving venous tone, reducing inflammation, and decreasing capillary permeability, which directly addresses the underlying vascular dysfunction. Numerous studies confirm its efficacy in significantly reducing key symptoms like bleeding, pain, itching, and discharge within days. Therefore, it is a well-established, evidence-based option for managing this common condition.
Q2:How long does it take for diosmin to work?
A2:Diosmin (typically combined with hesperidin) begins to exert its therapeutic effects relatively quickly. For acute conditions like a hemorrhoid crisis, many patients report noticeable symptom relief—such as reduced pain and swelling—within 2 to 4 days of starting treatment at the standard loading dose. For chronic issues like venous insufficiency, it may take 2 to 4 weeks of consistent use at the maintenance dose to achieve optimal and stable improvement in symptoms like leg heaviness and edema. The micronized form works faster due to enhanced absorption.
Reference：
https://verification.fda.gov.ph/files/DRP-12333_PI_01.pdf
https://www.nature.com/articles/s41598-023-38120-x
