Alpha GPC Powder

Alpha GPC Manufacturer

Healthkintai^® is a professional Alpha GPC powder manufacture, mainly producing 99% Alpha GPC powder and 50% and 85% specifications are also available.

We have a professional R&D team and laboratories to ensure that the product’s quality, safety, and innovation maintain an industry-leading position.

If you require high-quality 50%, 85% and 99% Alpha GPC powder, please feel free to contact us at health@kintaibio.com.

What is Alpha GPC?

Alpha GPC (Alpha-glycerylphosphorylcholine), also called L-alpha-glycerylphosphorylcholine, α-GPC and Alpha GPC choline alfoscerate, is a well-researched, evidence-backed nootropic compound. By efficiently elevating choline and acetylcholine levels in the brain, it demonstrates clear value in enhancing cognition, protecting nerve health, and improving athletic performance. For individuals seeking to boost mental performance, support long-term brain health, or optimize physical performance, it serves as an effective supplement choice.

The Technical Data Sheet (TDS) of Alpha GPC Powder

Regulatory Status of Alpha GPC

It is a non-prescription drug in most countries. The FDA determined that intake of no more than 196.2 mg/person/day is considered generally recognized as safe (GRAS).

(Referance: https://hfpappexternal.fda.gov/scripts/fdcc/index.cfm?set=grasnotices&id=419)

Alpha GPC Benefits

Enhances Memory & Learning Ability

Acetylcholine in the brain is a core neurotransmitter regulating memory, learning, and attention (known as the “memory messenger”), and choline is an essential raw material for acetylcholine synthesis. After entering the brain, α-GPC rapidly breaks down into choline and glycerol-3-phosphate, directly providing substrates for acetylcholine synthesis and significantly increasing cerebral acetylcholine levels. Additionally, α-GPC promotes synaptic connections between hippocampal (memory center) neurons, enhancing the efficiency of neural signal transmission.

Prevents & Improves Age-Related Cognitive Decline (Adjunctive Intervention for Dementia)

With aging, the brain’s choline synthesis capacity decreases, leading to reduced acetylcholine levels. Meanwhile, neuronal cell membrane phospholipids are lost (causing decreased membrane fluidity and neuronal apoptosis). α-GPC not only supplements choline to maintain acetylcholine levels but also acts as a precursor of phosphatidylcholine (a major component of cell membranes), repairing damaged neuronal membranes, reducing oxidative stress-induced neuronal damage, and delaying hippocampal atrophy.

Neural Damage Repair (Post-Stroke Rehabilitation, Adjunctive Treatment for Neurodegenerative Diseases)

For patients with ischemic stroke, α-GPC promotes neural repair through the following pathways: ① Supplementing membrane phospholipids to repair neuronal membrane damage caused by ischemia; ② Inhibiting neuronal apoptosis (via regulating the Bcl-2/Bax apoptotic pathway); ③ Promoting the expression of neurotrophic factors (e.g., brain-derived neurotrophic factor, BDNF) to accelerate the regeneration of damaged nerve fibers.

Note: The European Union has approved α-GPC for neurological function rehabilitation after ischemic stroke.

Mood Regulation (Adjunctive Improvement of Depression & Anxiety)

Acetylcholine in the brain synergizes with dopamine and serotonin (mood-regulating neurotransmitters). By increasing acetylcholine levels, α-GPC balances the dopaminergic and serotonergic systems, alleviating anxiety (especially “cholinergic-deficient anxiety” characterized by inattention and excessive worry). Additionally, α-GPC improves cerebral microcirculation, increasing oxygen supply to brain tissue and relieving fatigue associated with depression.

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Alpha GPC Supplements

Alpha GPC Dosage

Alpha GPC Side Effects

Alpha-GPC is generally well-tolerated when used short-term (typically within 6 months) at conventional doses (e.g., no more than 1200 mg per day). Common side effects are limited to mild gastrointestinal discomfort such as diarrhea and heartburn.

However, recent studies have raised concerns and controversies regarding its long-term safety: it may be metabolized in the intestines into trimethylamine N-oxide (TMAO), a compound associated with cardiovascular diseases. A large cohort study suggests that long-term use (≥12 months) may be linked to an increased risk of stroke, and animal experiments have also indicated that it may promote atherosclerosis. Nevertheless, this evidence remains preliminary, the causal relationship has not been established, and its clinical significance—especially in healthy populations—remains unclear, requiring further research for confirmation.

Special populations should exercise caution

Pregnant and lactating women should avoid use due to insufficient safety data; individuals at high risk of cardiovascular diseases should conduct a careful risk assessment before long-term use. Overall, short-term supplementation is relatively safe, but the potential risks of long-term use warrant attention. It is recommended to consult a healthcare professional prior to use.

Why Should You Buy Alpha GPC Powder from Healthkintai^®?

Healthkintai^®, as a supplier with 12 years of specialization in raw materials for health supplements, implements stringent quality control over its products.

Healthkintai^® possess specialized expertise in hygroscopicity management.
Alpha GPC itself is highly hygroscopic. We employ specialized formulation processes, such as by adding specific anti-hygroscopic excipients (e.g., silica, starch, resistant starch, etc.) and utilizing high-speed shear mixing, which can significantly enhance the moisture resistance of the final powder product. This process effectively improves the physical stability of the powder. The entire mixing process is conducted in a low-humidity environment (e.g., a drying room), and the mixed material is thoroughly dried.

If you want to order 50%, 85% and 99% Alpha GPC powder to make healthcare supplements, please feel free to contact us at health@kintaibio.com.

FAQ

1. Is Alpha-GPC good for bodybuilding?

Yes, Alpha-GPC can be good for bodybuilding by potentially boosting power, strength (like 14% on bench press), and growth hormone (GH) levels, which aids muscle growth, though GH spikes are often temporary, supporting focus and performance in workouts, especially for power/explosive lifts, but more research is needed for long-term muscle hypertrophy.

2. Does Alpha-GPC affect sleep?

Yes, Alpha-GPC can affect sleep, often causing difficulty sleeping or insomnia if taken later in the day, due to its stimulatory effects on acetylcholine, which boosts alertness; however, some anecdotal reports link it to better sleep quality when used correctly, though research is mixed, with some studies showing no impact on lucid dreams. To avoid sleep disruption, taking Alpha-GPC in the morning is generally recommended.

3. Is Alpha-GPC safe for the heart?

Alpha-GPC has mixed findings on heart safety; while short-term studies suggest it's generally well-tolerated and may even offer short-term heart cell protection, recent animal and human cohort studies link it to potential cardiovascular risks like atherosclerosis, increased stroke risk, and TMAO production, necessitating caution, especially for those with pre-existing heart conditions, and further research is crucial.