Peanut Shell Extract Luteolin Powder

Luteolin is an active natural flavonoid ingredient. For industrial production, peanut shells and sophora buds are commonly selected as extraction raw materials with sufficient supply. It exhibits favorable antioxidant effects to scavenge free radicals, alongside multiple physiological activities including anti-inflammation, soothing anti-allergy, antibacterial property and immunoregulation. It is widely adopted as a core raw material for dietary supplements and functional foods. In the skincare industry, it is incorporated into soothing and repairing skincare products to relieve sensitive and reddened skin. Furthermore, it acts as a vital intermediate for pharmaceutical research and development, with its applications continuously expanding into pet nutrition and natural feed additives.

Healthkintai^® has specialized in plant extracts for more than ten years. Our flagship bulk peanut shell extract luteolin powder covers specifications from 90% to 99%, tested by external standard HPLC with consistent purity batch by batch. Samples are available upon request. Welcome to contact us at health@kintaibio.com to send inquiries for quotations.

Luteolin is soluble in dimethyl sulfoxide (DMSO), dimethylformamide (DMF), pyridine and dilute alkaline aqueous solutions; slightly soluble in methanol, ethanol and acetone; sparingly soluble in ethyl acetate and diethyl ether; practically insoluble in non-polar solvents such as petroleum ether and n-hexane.

Luteolin Solubility in Water

Luteolin exhibits extremely low solubility in pure water at ambient temperature, with a solubility of approximately 1 mg/mL at 25°C, classified as practically insoluble. Its solubility rises slightly in hot water, yet the improvement remains limited. The molecule contains four phenolic hydroxyl groups and is weakly acidic, capable of forming salts with alkalis. Its solubility increases markedly in dilute alkaline aqueous solutions such as sodium hydroxide solution, yielding a dark yellow solution. Solubility remains poor under neutral and acidic aqueous conditions, and high-concentration aqueous solutions cannot be prepared under conventional conditions.

Is luteolin a flavonoid? Luteolin is a natural flavonoid widely distributed in the plant kingdom. Typical foods with luteolin cover vegetables including celery, sweet bell peppers, broccoli, carrots, thyme, perilla leaves and artichokes. Notably, celery luteolin is one of the commonly discussed dietary sources. Luteolin also accumulates at prominent levels in medicinal and edible plants such as honeysuckle and wild chrysanthemum. Within raw food materials, luteolin mostly exists in the form of luteolin glycosides.

For large-scale industrial extraction, peanut shells serve as the predominant raw material. The core rationale for selecting peanut shells is that they are bulk agricultural by-products from peanut processing, featuring abundant supply and low procurement costs with a relatively simple impurity profile, which reduces difficulties in separation and purification. This delivers distinct cost advantages compared with extraction directly from fresh vegetables, fruits or medicinal herbs.

Luteolin for MCAS

Luteolin is a natural mast cell membrane stabilizer that helps relieve discomforts associated with Mast Cell Activation Syndrome (MCAS). It blocks intracellular calcium influx, regulates PKC and NF-κB signaling pathways, and inhibits two major mast cell activation pathways, FcεRI and MRGPRX2. This reduces mast cell degranulation and lowers the release of histamine and tryptase, while suppressing the production of pro-inflammatory cytokines including TNF-α, IL-6, IL-8, as well as leukotrienes and PGD2. It also exhibits antioxidant properties.

Compared with cromolyn sodium, luteolin can not only reduce the release of immediate inflammatory mediators but also modulate the transcription of inflammatory factors. In addition, it can cross the blood-brain barrier to ease systemic allergic reactions triggered by MCAS, alongside neurological discomforts such as brain fog and headaches. It serves as a dietary support to alleviate multisystem physical symptoms caused by persistent abnormal mast cell activation.

Luteolin for Hair

Luteolin is a natural flavonoid antioxidant. Available animal research data indicate that luteolin helps delay premature grey hair. It slows the aging of follicular keratinocyte stem cells, stabilizes signal transmission between endothelin secreted by keratinocytes and endothelin receptors on melanocyte stem cells, preserves the pool of melanocyte stem cells in hair follicles, prevents stem cell depletion and inactivation, and continuously delivers melanin for new hair growth. Whether taken orally or applied topically, luteolin scavenges free radicals within hair follicles and alleviates oxidative damage, improving premature grey hair triggered by aging and mental stress.

Important note: Luteolin focuses on preventing new grey hair from forming; it cannot reverse gray hair that has already developed.

Luteolin Benefits for Men

Luteolin, a natural flavonoid active ingredient, helps support multiple bodily functions in men. It scavenges free radicals and modulates NF-κB-related inflammatory responses to ease chronic inflammation and oxidative stress in the body, supporting comfortable prostate conditions. It facilitates normal function of Leydig cells, assists in maintaining healthy testosterone levels and balanced hormone metabolism, and alleviates age-related energy decline in middle-aged men. It protects vascular endothelium and helps keep lipids within optimal ranges to reduce cardiovascular burden.

Additionally, it acts on the brain to relieve neuroinflammation, ease stress, stabilize mood and improve focus. It also stabilizes mast cells to mitigate respiratory hypersensitivity. Continuous supplementation helps men sustain stable endocrine, cardiovascular and nervous systems.

Luteolin Medical Use

Possessing multiple bioactivities such as anti-inflammatory, antiviral, neuroprotective and immunomodulatory properties, luteolin serves as an active component in some compound traditional Chinese medicinal formulations for symptoms associated with respiratory inflammation, swelling, pain and bleeding, and lipid metabolism modulation. Furthermore, it is widely utilized in preclinical studies for novel drug development, investigating intervention approaches targeting inflammatory bowel disease, allergic conditions and neurodegenerative disorders.

Luteolin Supplement

Luteolin is often formulated into standalone capsules and powders, or combined with palmitoylethanolamide (PEA), quercetin, resveratrol and curcumin to develop dietary supplements with composite antioxidant and conditioning formulas. End products are mainly positioned for respiratory comfort, chronic inflammation modulation, relief of allergic sensitivity, cognitive and neurological wellness, cardiovascular support, and auxiliary uric acid management. Meanwhile, microencapsulated luteolin can be incorporated into functional beverages, meal replacement powders and solid drinks to improve water solubility and mitigate bitter taste.

Luteolin in Cosmetics and Personal Care Products

Luteolin features antioxidant properties, soothing conditioning potential, free radical scavenging capacity and mild UV absorption characteristics. It helps sustain skin matrix stability, ease discomfort induced by external irritants and support improved skin appearance. It is frequently formulated synergistically with hyaluronic acid, phytosterols and niacinamide, suitable for serums, facial masks, creams, after-sun care and other skincare products.

Currently, there is no globally unified official standard for the dosage of luteolin. In human clinical studies, the common oral daily dose ranges from 50 mg to 500 mg; for example, 100 mg per day has been reported to show no dose‑limiting toxicity, while some studies use 300 mg or 500 mg daily. Commercially available dietary supplements typically recommend daily intakes ranging from 10 mg to 100 mg. Doses used in animal experiments vary considerably and, when scaled to humans, are often far higher than the common human doses. Overall, the specific amount of luteolin depends on the product type and research purpose, and no official standardized dosage has been established.

Healthkintai^® has years of experience in the R&D and large-scale production of plant extracts. We supply multi-specification wholesale peanut shell extract luteolin powder with purity ranging from 90% to 99%, suitable for diverse application scenarios including dietary supplements, pharmaceutical intermediates and cosmetic raw materials.

All products are manufactured in strict accordance with GMP quality management specifications without any chemical additives, delivering natural and pure raw materials. The minimum order quantity is as low as 1 kg. Equipped with complete foreign trade import and export qualifications, our company can provide full sets of technical documents such as COA and MSDS on request.

We also hold internationally recognized certifications including HACCP and HALAL, enabling our products to meet market access requirements of numerous countries. We sincerely welcome customers at home and abroad for inquiries and cooperation. Contact us at health@kintaibio.com.

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