Nicotinamide Riboside Chloride NR‑CL Powder

Nicotinamide Riboside (NR) is commonly used in its chloride form, namely Nicotinamide Riboside Chloride (NR-CL). Its English aliases include NRC, NR-CL and SRT647. As a member of the vitamin B3 family and an efficient precursor of NAD+, it works to raise cellular NAD+ levels, activate sirtuins, boost mitochondrial energy metabolism, delay cellular senescence, improve metabolic health and exert neuroprotective effects. It is widely applied in anti-aging dietary supplements, functional foods and beverages, cosmetic raw materials, laboratory reagents, as well as research on metabolic syndrome and neurodegenerative diseases.

Specializing in the production of dietary supplement raw materials, Healthkintai^® provides premium NAD+ precursor series products. Our products feature a purity of up to 99%, covering Nicotinamide Riboside Chloride NR‑CL powder, NMN powder and other mainstream ingredients in this category. We also offer liposomal products. We sincerely welcome your inquiries and look forward to establishing long-term cooperative partnerships with you. Please contact us at health@kintaibio.com.

Nicotinamide Riboside Chloride (NR-Cl) is the hydrochloride salt of Nicotinamide Riboside (NR). Both exert their biological effects in the form of NR in vivo with essentially identical biological functions. Their main differences lie in stability, water solubility and formulation applicability.

United States FDA

Nicotinamide Riboside Chloride has obtained a GRAS Notice No Objection Letter from the U.S. FDA, allowing its use in various conventional foods. It is also legally permitted as a dietary supplement under the NDI clearance, with a recommended daily dosage of 100–300 mg. The ingredient has been included in the USP monograph with specified purity and other quality criteria. Its injectable form is regulated as a compound preparation for prescription use in clinics. The core patents are set to expire in 2027, so relevant patent compliance risks shall be noted for commercial application.

European Union EFSA

Nicotinamide Riboside Chloride has been approved as a Novel Food in the EU and later officially recognized as a legitimate source of vitamin B3, with its scope of application expanded via regulatory amendments for use in foods and dietary supplements. The regulated maximum daily intake is 300 mg for adults and 230 mg for pregnant and breastfeeding women. The United Kingdom continues to adopt the above approval and dosage limits post-Brexit, which are also followed by Switzerland, Norway and other regions.

• Raw material preparation: Prepare nicotinamide (NAM), phosphoribosyl pyrophosphate (PRPP) and special enzyme preparations.
• Enzymatic catalytic reaction: In a buffer solution system, strictly control the pH at 6.5–7.5, temperature at 30–37℃ and reaction time for 4–6 hours. Raw materials are gently converted into nicotinamide riboside (NR) skeleton via efficient enzymatic catalysis.
• Reaction solution pretreatment: After the reaction, remove denatured protein precipitates by centrifugation, followed by filtration to eliminate residual enzyme proteins, insoluble matters and macromolecular impurities, so as to obtain a clear reaction solution.
• Preliminary purification: Adopt ion exchange column chromatography to remove most small molecular impurities and by-products, and greatly improve the purity of the target product.
• Fine purification: Further remove trace impurities to make the product purity meet the process standards.
• Concentration: Concentrate the solution to increase the content of the target product and reduce the solution volume.
• Chlorination conversion: Add hydrochloric acid into the concentrated solution and adjust the pH value to 2–3. Nicotinamide riboside (NR) binds with chloride ions and is converted into nicotinamide riboside chloride (NRC).
• Crystallization: Add ethanol to reduce the solubility of the product and promote the precipitation of NRC crystals.
• Solid-liquid separation: Collect the precipitated NRC crystals by vacuum filtration to separate crystals from mother liquor. Remove residual solvents and soluble impurities in the mother liquor to obtain pure wet crystals.
• Vacuum drying: Dry the wet crystals under vacuum to thoroughly remove moisture and residual organic solvents, and finally obtain dry and stable finished powder of nicotinamide riboside chloride.

NAD+ is the core coenzyme that functions directly inside cells. Nicotinamide Riboside (NR) acts as a precursor of NAD+. Orally administered NR is more readily absorbed by the body and then converted into NAD+ internally. Below is a comparison in four aspects: chemical structure, biological functions, absorption and supplement applications.

Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) are both precursors of NAD+. Their core function is to convert into the coenzyme NAD+ in the human body to exert physiological effects. The two substances share similar structures and closely related metabolic pathways.

They differ in molecular structure, metabolic processes and absorption efficiency: as a nucleoside, NR has a smaller molecular size and can be directly taken up by cells, then converted stepwise into NMN and ultimately into NAD+, featuring higher absorption efficiency. As a nucleotide, NMN has a slightly larger molecular size, and part of it needs to be broken down into NR before absorption and utilization. Though both work to boost intracellular NAD+ levels, NR has a shorter metabolic pathway and delivers faster results.

Nicotinamide Riboside for Men

Nicotinamide riboside , an active derivative of vitamin B3, can efficiently penetrate cell membranes and convert into NAD+ via the salvage pathway. NAD+ levels in men decline markedly with age, and supplementation with NR boosts cellular NAD+ content.

On one hand, it enhances mitochondrial energy metabolism and ATP production, relieving fatigue, improving physical stamina, supporting muscle repair and maintenance, and slowing muscle loss. On the other hand, it activates sirtuins and repair enzymes to accelerate DNA damage repair, reduce oxidative stress and chronic inflammation, and protect the cardiovascular, nervous, and reproductive systems. It also maintains androgen balance.

Nicotinamide Riboside for Women

NAD+ levels in women gradually decline with aging, irregular lifestyles, stress, and hormonal fluctuations. Supplementing with NR effectively raises intracellular NAD+ concentrations.

Firstly, it optimizes mitochondrial energy metabolism and boosts energy supply, alleviating fatigue caused by prolonged sitting, late nights, menstruation, and menopause, while improving complexion and mental state. Secondly, it activates sirtuins and DNA repair enzymes to reduce oxidative damage from free radicals, slow skin aging, and enhance skin condition. It also suppresses chronic inflammation, supports endocrine and ovarian health, and stabilizes hormone levels during menstruation and menopause.

Nicotinamide Riboside for Weight Loss

The weight loss effect of nicotinamide riboside mainly lies in raising cellular NAD+ levels, promoting mitochondrial biogenesis and fatty acid β-oxidation to accelerate fat breakdown and energy consumption. It also induces browning of white adipose tissue, enhances the thermogenic activity of brown fat to reduce fat accumulation and boost basal metabolic rate. Additionally, it improves insulin sensitivity, inhibits lipogenesis, and helps preserve muscle mass and prevent muscle loss during weight management.

Nicotinamide Riboside for Hair Growth

As a potent NAD+ precursor, nicotinamide riboside elevates intracellular NAD+ levels in hair follicle cells, activates sirtuins and energy metabolic pathways to supply ample energy for hair follicles. It improves microcirculation around follicles and boosts nutrient delivery to hair roots. Meanwhile, it repairs damaged hair follicles, prolongs the anagen phase and alleviates follicle atrophy and hair loss. It also regulates scalp metabolism and maintains a healthy scalp environment, thereby strengthening hair roots and facilitating normal hair growth.

In the Dietary Supplements

Nicotinamide Riboside (NR), a key precursor of NAD+, can effectively elevate intracellular NAD+ levels after oral administration. It is mainly marketed for anti-aging, energy boost, sleep improvement, metabolism enhancement and neuroprotection. It is commonly formulated into capsules, tablets, powders and nanoliposomes. To create differentiated products, NR is often combined with PQQ, resveratrol, collagen and other ingredients. Its primary consumer groups include people aged 35 to 65 seeking anti-aging effects, high-pressure office workers and sub-health middle-aged and elderly people.

In Functional Foods and Beverages

The application of NR in functional foods and beverages is expanding rapidly. Thanks to its good water solubility and high safety, NR can be incorporated into meal replacement powders, protein bars, nutritional drinks, probiotic preparations, foods for special medical purposes and dairy products. Microencapsulation and sustained-release technologies are adopted to improve its stability in aqueous systems. It is often combined with prebiotics, vitamins and minerals to deliver benefits including anti-fatigue, weight management and skin condition improvement.

In the Animal Nutrition and Feed Additives

Nicotinamide Riboside helps raise NAD+ levels in livestock, poultry and companion animals, improving metabolism, boosting immunity, delaying aging and enhancing reproductive performance. When added to feed for pigs, chickens, cattle and sheep in livestock and poultry farming, it optimizes meat quality, increases egg production, strengthens anti-stress capacity and reduces disease incidence. In aquaculture, it promotes fish growth and improves immunity and survival rate. For companion animals such as dogs and cats, it delays aging, supports joint health, and enhances coat luster and vitality.

Healthkintai^® specializes in the R&D and production of raw materials for dietary supplements. Within our NAD+ precursor product line, Nicotinamide Riboside is our flagship product. As its highly stable salt form, Nicotinamide Riboside Chloride is our best-selling specification with a purity of over 99%.

We have a professional R&D team that masters mature chemical synthesis technology to support large-scale production. Our manufacturing facilities operate in strict compliance with GMP standards, and we hold a full set of international certifications including HACCP, Halal and Kosher, ensuring reliable quality and full compliance.

Adopting an integrated model of independent R&D, production and sales, we are able to offer highly competitive prices. We sincerely welcome inquiries, quotations and business cooperation from all partners worldwide. Contact us at health@kintaibio.com for bulk Nicotinamide Riboside Chloride NR-CL Powder.

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