Mangiferin Powder

Mangiferin is a natural C-glycoside flavonoid belonging to the xanthone family. Mango leaves serve as the primary industrial extraction raw material. Rich in phenolic hydroxyl groups, this active ingredient delivers excellent free radical scavenging and antioxidant effects. It also provides broad-spectrum anti-inflammatory and antimicrobial benefits. Additionally, it helps ease respiratory discomfort, supports liver wellness, assists in regulating insulin sensitivity, optimizes immune function, alleviates cutaneous inflammatory reactions, and offers mild nourishing effects on the nervous system.

Mangiferin has mature industrial applications in various fields. In pharmaceuticals, it is used in products easing bronchial discomfort and new liver & metabolism regulating drug research. For dietary supplements, it is added to liver-protective, antioxidant and blood sugar-balancing powders and tablets. In cosmetics, it features in barrier-repair, brightening, after-sun and anti-aging skincare to calm redness, suppress melanin and reinforce skin barriers.

With over ten years of expertise in botanical extracts, Healthkintai^® holds independent invention patents related to mangiferin. We supply mangiferin powder in multiple specifications, including 15% (water-soluble), 60%, 95%, and 98% grades, suitable for formulas in pharmaceuticals, dietary supplements and cosmetics. Please contact us at health@kintaibio.com to share your formulation requirements with us for further cooperation discussion.

 

 

Mangiferin is a polyphenolic glycoside with moderate overall polarity. Its solubility varies significantly with solvent polarity and temperature. At room temperature, it is only slightly soluble in moderately polar organic solvents, and its solubility increases markedly upon heating. It exhibits the best solubility in DMSO, a strongly polar aprotic solvent, and a clear concentrated solution can be obtained with the assistance of ultrasonication. It is sparingly soluble in methanol and ethanol, while its dissolution is greatly improved in hot dilute methanol and hot dilute ethanol. It is practically insoluble in weakly polar and nonpolar organic solvents such as diethyl ether, chloroform, petroleum ether and n-hexane, and barely soluble in acetone and ethyl acetate. Overall, its solubility follows the rule that higher solvent polarity and higher temperature lead to better dissolution performance.

Mangiferin Solubility in Water

Mangiferin has extremely poor water solubility at room temperature. Its saturated solubility in pure water at 25 °C is less than 0.1 mg/mL, making it practically insoluble in cold water. Its solubility rises slightly with temperature; only a small amount can dissolve in boiling or hot water, and merely low-concentration dilute solutions can be prepared. High-concentration aqueous mangiferin solutions cannot be formulated with pure water alone.

Our 15% water-soluble mangiferin is processed via exclusive modification technology, which greatly enhances the hydrophilicity of the raw material. It can be rapidly dispersed and dissolved in clean water at room temperature to form a clear solution without obvious precipitates. Compatible with all kinds of aqueous formula systems, it can be directly incorporated into oral liquids, water-based skin care products, liquid beverages, water-soluble powders and other products without ethanol as a solubilizer. It features lower usage barriers and broader application scenarios.

USA

In the United States, low-purity mangiferin extracts from mango leaves can be freely circulated as botanical dietary supplement raw materials, and enterprises may complete self-affirmed GRAS filings for use in functional foods, sports nutrition capsules and tablets. Although there is no official GRAS notice for high-purity mangiferin monomer, it also qualifies for the self-affirmed GRAS pathway. There is no legally mandated maximum daily intake limit, while the generally accepted safe industry dosage of pure mangiferin does not exceed 500 mg per day. For cosmetic applications, it is a compliant botanical active ingredient with antioxidant and soothing effects. From a chemical regulatory perspective, mangiferin is not listed on the TSCA Inventory. Small-volume imports for food and cosmetic use are generally exempt from TSCA notification, whereas bulk industrial imports require prior TSCA pre-notification.

EU

In the EU, low-content crude extracts are exempt from EFSA Novel Food applications due to their historical consumption as herbal tea, while highly purified mangiferin monomers are subject to mandatory Novel Food approval. The regulation sets an acceptable daily intake (ADI) of mangiferin at 0.3 mg per kilogram of body weight, and finished products must be labeled with the maximum recommended dosage. For pharmaceutical uses, CEP (Certificate of Suitability to the monographs of the European Pharmacopoeia) can be applied for, yet mangiferin is only used in homeopathic and topical herbal preparations with no approved human medicinal products based on the monomer. In cosmetics, it is included in the CosIng database without prohibited or restricted concentration limits. Chemically, mangiferin has no EINECS registration number, and small shipments of food and cosmetic materials with an annual export volume below 1 ton are exempt from REACH registration.

Mangiferin for Diabetes Management

Mangiferin regulates blood glucose homeostasis in the body through multiple synergistic mechanisms. It inhibits intestinal α-glucosidase activity to slow down the breakdown and absorption of starch and sucrose, mitigating sharp postprandial blood glucose spikes. Meanwhile, it activates the AMPK signaling pathway in muscle and adipose tissues, upregulates the expression of GLUT4 glucose transporters, and accelerates glucose uptake and metabolism in peripheral tissues. Additionally, it suppresses key enzymes involved in hepatic gluconeogenesis to reduce endogenous glucose production.

Furthermore, it alleviates oxidative stress damage to pancreatic β-cells, improves bodily insulin sensitivity and alleviates insulin resistance. Via three approaches-smoothing postprandial blood glucose peaks, cutting endogenous glucose synthesis, and enhancing insulin responsiveness-it helps support stable blood glucose levels.

Mangiferin for Liver

Mangiferin exerts hepatoprotective effects through multiple mechanisms. It activates the liver's intrinsic antioxidant defense system to scavenge free radicals and mitigate oxidative damage. Meanwhile, it suppresses inflammatory signaling pathways to reduce the levels of pro-inflammatory factors and relieve chronic hepatic inflammation. In addition, this active ingredient helps block the progression of liver fibrosis and modulates lipid metabolism to alleviate hepatic fat accumulation.

Studies across various liver injury models have verified that mangiferin can effectively reduce transaminase levels and improve liver function markers. While these results are derived from cellular and animal trials, mangiferin, as a natural bioactive compound, demonstrates promising potential for supporting liver health.

Mangiferin for Nerve and Cardiovascular Protection

For nervous system support, mangiferin upregulates the activity of the PI3K/Akt/mTOR signaling pathway and blocks transmission of the MCP-1/CCR2 inflammatory pathway, alleviating cerebral oxidative stress and inflammatory responses and reducing abnormal neuronal apoptosis. Existing experimental data indicate this natural bioactive compound helps improve cognitive performance and offers auxiliary protective effects against brain tissue discomfort induced by cerebral ischemia, hypoxia and abnormal blood pressure.

In terms of cardiovascular support, mangiferin activates the Nrf2 pathway to boost the heart's intrinsic antioxidant defense capacity while suppressing the activity of inflammatory pathways including NF-κB, mitigating tissue damage caused by myocardial ischemia-reperfusion and oxidative stress. In addition, it helps restore vascular endothelial function, inhibits abnormal platelet aggregation, and regulates lipid metabolism in the body to deliver multi-dimensional support for cardiovascular wellness.

Mangiferin for Skin

With synergistic antioxidant, anti-inflammatory and skin barrier-supporting properties, mangiferin aids skin care. It scavenges excess free radicals in the epidermis and dermis, alleviates lipid peroxidation triggered by UV rays, and improves aging concerns such as dullness and uneven skin tone. Meanwhile, it suppresses the secretion of various pro-inflammatory factors to soothe sensitive skin issues including redness and itching. It also modulates pathways related to melanin production to gently lighten pigmentation, stimulates the synthesis of functional proteins in the stratum corneum to strengthen the skin barrier, and reduces irritation caused by external environmental stressors, offering multi-faceted support to maintain even, stable and healthy skin.

Mangiferin Medical Use

Pharmaceuticals represent the largest application market for mangiferin, with downstream buyers mainly sourcing high-purity pharmaceutical-grade products of 95% and 98%. Mangiferin boasts a wide range of application scenarios. It is applied in the intervention and treatment of chronic disorders including chronic bronchitis, chronic hepatitis, rheumatoid inflammation and metabolic syndrome. It can also be utilized for the development of Class II innovative drugs for adjuvant diabetes therapy. Meanwhile, it serves as an auxiliary chemotherapeutic agent to induce apoptosis of tumor cells, alleviate oxidative damage caused by radiotherapy and chemotherapy, and reduce cardiovascular complications. In addition, thanks to its antibacterial and anti-inflammatory properties, mangiferin can be formulated into topical ointments and oral rinses for the treatment of dermatitis and oral ulcers.

Mangiferin Supplements

Mangiferin has been included in the list of safe natural edible raw materials by many countries and is widely used in dietary supplements for blood sugar control, liver protection, anti-aging and immune regulation. Its downstream finished products come in forms such as tablets and capsules. The addition of mangiferin to low-GI functional drinks and fermented dairy products can significantly lower the glycemic index, making these products suitable for people managing blood sugar. Compound liver-protecting health products are often formulated with extracts of pueraria and silymarin to alleviate liver damage induced by alcohol and medicines. Anti-aging and brain-nourishing supplements for middle-aged and elderly people leverage its neuroprotective effects to relieve oxidative brain aging and improve memory loss.

Recommended dosages of mangiferin vary significantly across different application scenarios. For oral human dietary supplements, the standard daily intake ranges from 100 to 500 mg. A daily dose of 100–300 mg, taken in 1 to 2 divided portions, is commonly used for daily blood sugar control and liver care, while the dosage can be increased to 300–500 mg per day for conditioning metabolic syndrome and liver damage.

Doses for clinical pharmaceutical preparations are adjusted based on purity and therapeutic indications, with dosages up to 500–1000 mg per day adopted in clinical trials of Class II innovative drugs; such doses must be taken at separate times under medical guidance to reduce gastrointestinal irritation. For topical skin and oral preparations, mangiferin is incorporated at a formulation concentration of 0.05%–0.2%.

Much lower dosages are applied as an antibiotic substitute in animal feed: 5–50 grams of crude mangiferin per ton of feed delivers antioxidant and intestinal-protective effects.

In terms of safety thresholds, humans exhibit good short-term tolerance to daily doses under 1 g, whereas long-term continuous administration is not advised to exceed 800 mg per day.

Healthkintai^® holds independent patented technology for the production of mangiferin powder. Our product is extracted from premium mango leaves as the core raw material, featuring stable purity and high activity. Our best-selling specifications include water-soluble 15% mangiferin, as well as high-purity grades of 60%, 95% and 98%. Customers may select the suitable grade flexibly according to their own formulas and production requirements for precise matching.

We are equipped with a professional R&D team and self-owned standardized manufacturing plants. By eliminating intermediate distributors, we are able to offer globally competitive mangiferin price. Full sets of compliant documents such as COA (Certificate of Analysis) and SDS (Safety Data Sheet) are available for all batches. Our products have obtained authoritative certifications including HACCP food safety system and Halal, complying with international export standards with outstanding compliance and wide applicability.

With years of mature practical experience in foreign trade exports, please feel free to contact us at health@kintaibio.com. We will provide you with worry-free, efficient and stable long-term supply support.

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