Bitter Orange Extract Hesperidin Powder

What is Bitter Orange Extract Hesperidin?​

Hesperidin is a natural flavonoid glycoside, mainly extracted from the peel and young fruit of citrus plants (such as bitter orange, sweet orange, and lemon) belonging to the Rutaceae family. It has the effects of enhancing capillary toughness, anti-oxidation, and anti-inflammation, and is often used to improve blood circulation, relieve varicose veins and blood stasis. It is also one of the main components of "vitamin P" and is widely used in food, medicine, and health products.

Healthkintai^® is a manufacturer and supplier of hesperidin, an extract from bitter orange. We offer 98% hesperidin powder and 98% neohesperidin powder. (Other specifications can be customized). Please feel free to contact us at info@kintaibio.com.

KINTAI Bitter Orange Extract Specifications

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Hesperidin vs Neohesperidin​

Hesperidin is a natural flavonoid glycoside widely found in the peels of citrus fruits such as sweet oranges and lemons, with a slightly bitter taste. Its main benefits lie in enhancing capillary resilience, anti-oxidation, and anti-inflammation; it is considered a core component of "vitamin P" and is commonly used in products that improve venous circulation and vascular health.

Neohesperidin, primarily derived from bitter orange and trifoliate orange peel, has a strong bitter taste. Its key value lies not in direct use, but as an important precursor, which, through catalytic hydrogenation, can be converted into a high-intensity sweetener—neohesperidin dihydrochalcone.

The main difference between the two lies in the way their glycosyl groups are linked in their chemical structures, directly resulting in diametrically opposed taste characteristics: hesperidin has a slightly bitter taste, while neohesperidin is extremely bitter. Furthermore, their core natural sources also differ.In applications, hesperidin is used directly as a bioactive ingredient in the pharmaceutical and healthcare fields; while neohesperidin is mainly used as an industrial intermediate in the production of high-intensity sweeteners and flavor modifiers, serving the food processing industry.

Bitter Orange Extract Hesperidin Benefits

1. Promotes Cardiovascular Health

Hesperidin, a key component of bitter orange extract, is highly effective in promoting cardiovascular health and improving microcirculation. It effectively reduces vascular fragility by enhancing the toughness and elasticity of capillary walls, thereby helping to improve blood circulation and alleviate problems such as leg heaviness and edema caused by venous insufficiency. Clinically, it is often used to treat chronic venous insufficiency and for related vascular protection.

2. Antioxidant and Anti-inflammatory

Hesperidin exhibits powerful antioxidant and anti-inflammatory effects. As a potent flavonoid antioxidant, it effectively neutralizes free radicals in the body, reduces oxidative stress-induced cell damage, and inhibits the release of pro-inflammatory factors. This dual mechanism not only helps delay cellular aging but also has positive implications for preventing chronic diseases caused by inflammation and oxidative damage.

3.Bitter Orange Extract for Weight Loss​

 In the fields of metabolic support and weight management, hesperidin has a synergistic effect with other active ingredients in bitter orange (such as synephrine). Studies have shown that it can support overall weight management strategies by improving insulin sensitivity and regulating lipid metabolism, but its role is usually as part of a comprehensive approach rather than as a direct weight-loss stimulant.

4. Hesperidin in skincare​

In addition, hesperidin and Neohesperidin has shown potential for protecting skin health. Due to its antioxidant and anti-inflammatory properties, it helps protect the skin from environmental damage such as UV rays and may improve skin elasticity by promoting collagen synthesis and stabilization. Therefore, it also has a place in some oral beauty and topical skincare products.

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Uses of Bitter Orange Extract Hesperidin

1. Hesperidin in Pharmaceuticals

Hesperidin, a natural flavonoid glycoside, plays a central role in the pharmaceutical and health product fields, primarily used for cardiovascular health and improving venous function. It is a key component of Vitamin P, widely used to treat chronic venous insufficiency, hemorrhoids, capillary fragility and bleeding, and postoperative edema by enhancing capillary resilience and reducing vascular permeability. It also serves as an adjunct component in cardiovascular protection.Diosmin and hesperidin are two closely related flavonoids that are often used in combination, especially in the treatment of vascular diseases. They are usually used in the form of standardized compounds (such as "micronized purified flavonoids containing 90% diosmin and 10% hesperidin").

2. Bitter Orange Extract Supplements

In the food and beverage industry, hesperidin gains significant applications due to its bioactivity and stability. On one hand, it is added to functional beverages and dietary supplements as a nutritional fortifier, claiming antioxidant and circulation-promoting effects. On the other hand, its natural antioxidant properties help extend the shelf life of some foods, although its slightly bitter flavor limits its direct use in flavoring.

3. Hesperidin in Skincare and Cosmetics

The cosmetics and personal care fields utilize hesperidin's excellent antioxidant and photoprotective capabilities. Because it effectively scavenge free radicals and reduce skin damage caused by ultraviolet radiation, and is believed to have the potential to promote collagen production and improve skin microcirculation, it is widely used in high-end skincare products such as serums, creams, and eye creams for anti-aging, whitening, sun protection, and improving microcirculation around the eyes (e.g., alleviating dark circles).

4. Hesperidin Feed Additive

In the agricultural and feed sectors, the application value of hesperidin is mainly based on its natural and safe bioactivity. It is being researched or used as a natural plant growth regulator and animal feed additive, aiming to utilize its antibacterial, anti-inflammatory, and antioxidant properties to enhance the health and resistance of plants and animals, reduce the use of chemical drugs, and align with the development trend of green agriculture.

Bitter Orange Extract Hesperidin Dosage​

Bitter Orange Extract Hesperidin Side Effects

Although hesperidin, a component of bitter orange extract, is generally considered a relatively safe natural ingredient, its use still carries some potential side effects and risks that require attention. The primary concern is that high doses may cause gastrointestinal discomfort, such as nausea, abdominal pain, or diarrhea. More importantly, because hesperidin may interact with other active ingredients (such as synephrine in the extract) to affect the cardiovascular system, some sensitive individuals may experience symptoms such as palpitations and elevated blood pressure.

Furthermore, due to its biological activity, it may interact with anticoagulants (such as warfarin), antihypertensive drugs, and other drugs metabolized by specific enzymes in the liver, affecting efficacy or increasing risks. Therefore, pregnant women, breastfeeding women, patients with cardiovascular disease, and those currently taking medications must consult a healthcare professional before using any related supplements.

Why Choose KINTAI Bitter Orange Extract Hesperidin?

1. Premium Raw Materials

Choosing our hesperidin powder stems from our unwavering pursuit of superior quality. Firstly, we insist on rigorously selecting raw materials globally, sourcing only fresh peels directly from the core bitter orange producing regions, ensuring the purity and high activity of the ingredients from the source.

2. Multiple Certifications

Our production system has obtained multiple authoritative international certifications, including HACCP, cGMP, ISO22000, and US FDA factory registration, ensuring that every step from production to finished product meets the highest global food safety and quality control standards.

3. Customized Services

We deeply understand the diverse needs of our clients and offer highly flexible customized services. Whether it's purity (from 50% to 98% and above), mesh size, or packaging specifications, we can personalize them according to your specific application scenarios, becoming your most reliable partner in product development and supply chain.

FAQ

Q1:Is hesperidin a blood thinner?

A1:Hesperidin is not a potent, direct blood thinner like prescription anticoagulants (e.g., Warfarin). However, it exhibits mild antiplatelet and potential vasoprotective effects, meaning it may slightly reduce the tendency of blood platelets to clump together and strengthen blood vessels. This can contribute to improved circulation. Importantly, due to this activity, it may interact with blood-thinning medications (like aspirin or warfarin), potentially increasing the risk of bleeding. Therefore, individuals on such medications should consult a doctor before taking hesperidin supplements.

Q2:Is hesperidin safe for kidneys?

A2:Some research even suggests potential renal protective benefits due to its strong anti-inflammatory and antioxidant properties, which may help reduce kidney damage caused by oxidative stress or certain toxins.However, for individuals with pre-existing kidney disease or severe renal impairment, caution is advised. Since the metabolites are excreted via the kidneys, high-dose supplementation could theoretically place additional strain on compromised renal function. Consulting a healthcare professional before use is strongly recommended in such cases.

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