Natrol Melatonin Time Release

Melatonin is one of the hormones secreted by the pineal gland. It can inhibit the activity of the hypothalamus-pituitary-target axis, reduce the concentration of cortisol in the blood, regulate people's natural sleep, overcome sleep disorders, and improve sleep quality. The secretion of melatonin in the human body follows the rule of low during the day and high at night, generally reaching a peak at around 2 a.m. As people age, melatonin will be insufficiently secreted, leading to sleep disorders and a series of functional disorders. Therefore, supplementing melatonin from outside the body can maintain the level of melatonin in the body at a young state, adjust and restore the circadian rhythm, play a role in deepening sleep, improving sleep quality, improving the body's functional state and delaying aging.

Does melatonin have any adverse effects?

Many studies have shown that melatonin supplementation is reliably safe even for children. In a 2020 experiment, 19 studies of 841 children and adolescents with delayed sleep-wake phase disorder (DSPD) demonstrated that melatonin can shorten the time to fall asleep by at least 22 minutes and up to 60 minutes, without any adverse events.

In addition, in a long-term safety study lasting from 1 year to nearly 11 years, melatonin supplementation did not show any unexpected problems in puberty development, mental health scores, or sleep quality in children to adolescents. In the UK, no adverse events were reported for 35 million doses of melatonin within 3 mg between 2008 and 2020.

It can be seen that the safety of melatonin is trustworthy. Adults can take it with confidence within the daily safe dose of 1-3 mg stipulated by Chinese regulations. Other countries allow children and adolescents to take low doses of melatonin.

What is the optimal dose of melatonin?

Melatonin should not be taken excessively. It only needs to be taken at the lowest effective dose. According to the research results of the University of Cleveland Clinic, occasional mild insomnia generally only needs 0.3 mg to 1 mg of melatonin per day. Excessive use will bring adverse consequences, including:

♦Insomnia worsens
♦Loss of effectiveness over time, brain receptors become insensitive to melatonin, and melatonin supplementation loses its effect
♦Headache
♦Nausea
♦Sleepiness the next day, affecting work performance
♦Lower body temperature in the elderly
♦Interaction with other drugs

Will melatonin supplementation cause dependence?

The root cause of side effects for some consumers after long-term use of melatonin is overdose, not melatonin itself. Taking melatonin within a reasonable dose will not cause dependence.

According to the research results of Dr. Luis Buenaver, a researcher at Johns Hopkins University, if melatonin does not help sleep after taking it for one or two weeks, stop using it and use other means to improve sleep; if it helps sleep, you can take it for 1-2 months to improve it, then stop taking it and take other natural ways to help increase the production of melatonin, such as keeping the lights dim before going to bed, and stop using computers, smartphones or tablets before going to bed, because the blue and green light emitted by these devices can neutralize the effects of melatonin. At the same time, exposure to sunlight in the morning and afternoon can promote the production of melatonin at the right time. In addition, foods rich in tryptophan, including milk, millet, seaweed, soybeans, mushrooms, etc., can also promote the production of melatonin.

When should melatonin be taken to achieve the best effect?

There are some disagreements about the best time to take melatonin, but almost all consumers who have taken melatonin believe that taking it too late (before going to bed) will increase the probability of feeling sleepy the next day.

Generally speaking, it is best not to take melatonin just before going to bed. Dr. Luis Buenaver believes that melatonin levels begin to rise about two hours before going to bed, so it is recommended to take it two hours before going to bed; German researchers advocate taking melatonin one to two hours before going to bed; in addition, according to John Andrefsky, MD, of Northeastern Ohio University Hospital, the best time to take melatonin supplements is to start taking it three to five hours before the sunlight dims and the body's melatonin storage increases. For example, if you fall asleep around 11 o'clock, you need to take melatonin at 6 pm.

Who should not take melatonin?

According to research from Johns Hopkins University, in addition to the people who are not suitable for use as indicated by current regulations, people with epilepsy or depression cannot use melatonin. Patients with diabetes or hypertension also need to be cautious because melatonin supplements may also increase blood sugar and blood pressure levels in people taking certain antihypertensive drugs.

Raw Material Name	Daily Dosage				Effect
Name	Dosage Range	Appropriate Crowd	Unsuitable Groups of People	Precautions
Melatonin	1-3mg	Aldult	Children, pregnant women, nursing mothers	People who are engaged in driving, mechanical operation or dangerous operation should not consume it before or during operation. Patients with autoimmune diseases (rheumatoid arthritis, etc.) and hyperthyroidism should use it with caution.	Improve sleep

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