Salidroside Powder
Specification: 98% Salidroside (Other specifications can be customized)
Test Method: HPLC
CAS Registry No: 97404-52-9
Appearance: White powder
Function: Antioxidant
Applications: Daily chemical industry
Certifications: GMP, ISO9001:2015, ISO22000:2018, HACCP, KOSHER, HALAL
MOQ: 1KG
Sample: Free sample available
Production Capacity: 2000KG/month
Delivery Time: Delivery within one day from warehouse
Shelf Life: 2 years
Payment:T/T
Company Advantage: 100,000 level clean production workshop, Non-additive, Non-GMO, Non-Irradiated/treated by heat only.
- Fast Delievery
- Quality Assurance
- 24/7 Customer Service
Product Introduction
Rhodiola Rosea Extract Salidroside Suppliers
Salidroside is the core active ingredient of Rhodiola rosea, a plant found in high-altitude regions, and is known as a "high-altitude acclimatization agent." It has significant anti-fatigue effects, enhancing physical performance, accelerating lactic acid clearance, and promoting physical recovery. Its powerful adaptogenic properties help the body resist altitude sickness, stress, and other environmental stressors.

Healthkintai® is a producer and supplier of Rhodiola rosea extract. We offer 98% Salidroside (other specifications are customizable). We have a large-scale production plant and a professional R&D team, enabling us to provide customized services. If you require high-quality rhodioloside powder, please feel free to contact us at info@kintaibio.com.
KINTAI's Advantages
- Superior product quality: We select premium Rhodiola rosea raw materials and introduce advanced processes and equipment to achieve strict control over the entire production process. This ensures that our 98% Rhodiola rosea glycoside product exhibits outstanding performance in purity, content, and batch stability, guaranteeing reliable quality.
- Strong R&D capabilities: The company has a professional R&D team and collaborates closely with several renowned universities and research institutions, enabling us to continuously track the latest technological developments. Based on this, we can quickly respond to the market, providing customers with customized product specifications and solutions, driving continuous product innovation and upgrades.
- Proactive market expansion:By actively participating in domestic and international industry exhibitions and academic exchanges, we continuously explore market trends, expand business channels, and use this experience to improve our technology and service levels, propelling the company's continuous growth and development.
KINTAI Salidroside COA

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Physicochemical Properties of Salidroside
|
Property |
Description |
|
Chemical Name |
2-(4-Hydroxyphenyl)ethyl-β-D-glucopyranoside |
|
CAS Number |
10338-51-9 |
|
Molecular Formula |
C₁₄H₂₀O₇ |
|
Molecular Weight |
300.30 g/mol |
|
Appearance |
White to off-white crystalline powder |
|
Melting Point |
Approximately 158°C - 162°C |
|
Solubility |
Water: Soluble |
|
Optical Rotation |
[α]²⁵D: -33° to -38° (c = 1.0 in Methanol) |
|
Stability |
Stable under recommended storage conditions (cool, dry place). Sensitive to prolonged exposure to strong light, high temperature, and oxidative conditions. |
|
Glycoside Nature |
Hydrolyzable by strong acids or specific enzymes (β-glucosidase) into its aglycone (tyrosol) and glucose. |

Salidroside Mechanism of Action
Its core action is linked to the activation of key cellular signaling pathways, particularly the Akt and Nrf2 pathways. By activating Akt, salidroside promotes cell survival, energy metabolism, and mitochondrial function, which underlie its anti-fatigue and neuroprotective effects. Simultaneously, it activates the Nrf2 antioxidant pathway, leading to the upregulation of protective enzymes like heme oxygenase-1 (HO-1), thereby combating oxidative stress.

Furthermore, Rhodiola extract demonstrates significant anti-inflammatory activity by suppressing the NF-κB pathway, reducing the production of pro-inflammatory cytokines. It also influences key neurotransmitters in the brain, such as serotonin and dopamine, contributing to its observed antidepressant and adaptogenic properties. In essence, salidroside acts as a multi-target agent, enhancing cellular resilience to stress, inflammation, and oxidative damage.
Benefits of Rhodiola extract
1. Anti-fatigue
Salidroside' most recognized characteristic is their anti-fatigue effect. Its mechanism of action goes beyond simple energy replenishment. It penetrates deep into the cellular level, significantly improving mitochondrial efficiency and promoting the synthesis of ATP (adenosine triphosphate), the body's most basic energy unit, thus ensuring energy supply from the source. Simultaneously, it optimizes the body's energy metabolism strategy, promoting efficient utilization of fats and carbohydrates, and effectively reducing blood lactate and blood urea nitrogen levels after strenuous exercise, accelerating the elimination of metabolic waste. This not only significantly prolongs the time to exhaustion during exercise but also promotes rapid physical recovery, comprehensively improving endurance and athletic performance.
2. Antioxidant and Anti-aging
Salidroside are potent natural antioxidants, achieving their antioxidant effect through a dual pathway. On one hand, their unique chemical structure directly neutralizes and eliminates excess harmful free radicals produced in the body; on the other hand, they activate the body's inherent antioxidant defense system, significantly increasing the activity of key antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Through this "external cleansing and internal enhancement" mechanism, it effectively protects cell membranes, proteins, and DNA from oxidative damage, thereby slowing down the aging process of cells and even the entire body.

3. Neuroprotection and Improved Cognitive Function
Salidroside powder exhibits strong protective potential against the central nervous system. It can regulate the levels of neurotransmitters closely related to mood and cognition in the brain, such as serotonin, dopamine, and norepinephrine, thereby producing positive antidepressant and anti-anxiety effects. Furthermore, it can promote cerebral blood circulation, increase the supply of oxygen and glucose to brain tissue, and inhibit neuroinflammatory responses. These synergistic effects collectively benefit enhancing learning and memory abilities, improving concentration, and combating neurodegenerative diseases.
4. Cardiovascular and Cerebrovascular Protective Effects
Studies have confirmed that Salidroside has a clear protective effect on the cardiovascular and cerebrovascular systems. It can enhance the hypoxia tolerance of cardiomyocytes and improve coronary blood flow, thereby protecting cardiac function. Simultaneously, it also has a mild effect of dilating peripheral blood vessels, improving microcirculation, and reducing blood viscosity. These effects collectively provide solid support for maintaining healthy blood pressure levels and preventing myocardial ischemia and atherosclerosis, and have long-term positive significance for cardiovascular and cerebrovascular health.
Uses of salidroside
1. Salidroside Supplements and Function Foods
This is the primary application area for Rhodiola extract. With its significant anti-fatigue properties and ability to enhance the body's tolerance to hypoxia as its core selling points, it is widely used in anti-fatigue supplements, sports nutrition products, and special health products for high-altitude travelers. Its adaptogenic properties are also frequently used in various dietary supplements to help modern people relieve stress and improve sub-health conditions.

2. Salidroside Pharmaceuticals
This is its high-value-added application area. Research focuses on its neuroprotective effects for developing potential drugs to improve cognition, combat depression, and fight Alzheimer's disease. Its potential in protecting the cardiovascular system (such as against myocardial ischemia and improving microcirculation) also makes it a new candidate drug for adjunctive treatment of cardiovascular diseases. Furthermore, its powerful antioxidant and anti-inflammatory properties are attracting attention for delaying aging and preventing related chronic diseases.

3. Cosmetics and Personal Care
Rhodiola extract is a popular ingredient in high-end skincare products. Its powerful antioxidant capacity can neutralize free radicals that cause skin aging, playing a role in anti-wrinkle and delaying photoaging. At the same time, it can also promote skin metabolism and microcirculation, improve dull skin tone, and give products the effects of "brightening skin tone" and "delaying aging". It is often used in products such as serums and face creams.

Salidroside Dosage
|
Dosage Form |
Typical Dosage Range |
Key Context & Notes |
|
Dietary Supplement (Standardized Rhodiola extract) |
200 - 600 mg per day |
This is for a Rhodiola extract, typically standardized to 1% Salidroside (and often 3% Rosavins). Therefore, the actual Salidroside dose is 2 - 6 mg per day. |
|
Pure Salidroside (Research/Clinical) |
100 - 400 mg per day |
Dosages in clinical studies for specific conditions (e.g., fatigue, altitude sickness) often use purified extracts. This range is based on limited human trials. |
|
Administration |
Once daily, or split into two doses. |
Taken in the morning, before breakfast or lunch, to avoid potential interference with sleep. |
|
Cycle |
Cyclical use is common (e.g., 4-6 weeks on, 1-2 weeks off). |
This may help maintain efficacy and prevent the body from developing a tolerance. |
Salidroside Side Effects
Salidroside is generally considered safe and well-tolerated when taken at recommended dosages. However, like any bioactive compound, it may cause side effects in some individuals, primarily when consumed in high amounts.
The most commonly reported side effects are mild and related to its stimulant-like properties. These may include nervousness, irritability, insomnia (especially if taken late in the day), and mild headaches. Due to its potential to affect blood pressure and blood sugar, individuals with related medical conditions should use it with caution.

Given its origin from Rhodiola rosea, it may carry a low risk of allergic reactions. Crucially, due to the lack of comprehensive safety data, pregnant and breastfeeding women are advised to avoid use. It is always recommended to consult a healthcare professional before starting supplementation to assess personal risk.
Where to buy the best Rhodiola Extract?
We have been deeply involved in the plant extract industry for over a decade and are a leading manufacturer and supplier of plant extracts in China. We implement strict control over our products from the very beginning, ensuring 98% Rhodiola Rosea Extract Powder for you. If you are interested in our Rhodiola Rosea Extract Powder, please feel free to contact us at info@kintaibio.com.
FAQ
Q1:What is the difference between Rosavin and salidroside?
A1:Rosavin and salidroside are both major active ingredients in Rhodiola rosea, but they have different chemical structures. Rosavin belongs to the phenylpropanoid glycoside class, while salidroside belongs to the phenylethanol glycoside class. Both possess anti-fatigue and adaptogenic properties, but studies have found differences in their mechanisms of action and potency. It is generally believed that a standardized Rhodiola rosea extract should contain both of these components to produce a more comprehensive synergistic effect.
Q2:What does rhodiola do to your body?
A2:Rhodiola rosea is an adaptive herb that primarily acts on the human neuroendocrine system and energy metabolism. It helps the body cope with physiological and psychological stress by regulating the release of stress hormones such as cortisol, thereby reducing fatigue and improving endurance and stress resistance. Simultaneously, it promotes the production of cellular energy molecules (such as ATP), improving oxygen utilization in the brain and cognitive functions such as memory and concentration. Furthermore, it has certain anti-anxiety and mood-boosting effects. Its core active ingredients (such as rhodioloside and rosavin) work together to support overall homeostasis and adaptability.
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