Polydatin Powder

Polydatin Powder Manufacturers and Suppliers

Polydatin powder is a natural active ingredient extracted from the dried rhizome of Polydatin. It has the functions of protecting liver and gallbladder, antiviral, antibacterial, antioxidant, etc. It has significant protective effects on cardiomyocytes and hepatocytes, and can reduce tissue and organ damage caused by various factors.Healthkintai^® is a high-quality manufacturer and supplier of polygdatin in China. We select Polygonum cuspidatum roots from the source to ensure the purity and quality of the extract. All products come from the factory. We can provide the most favorable prices and provide technical and creative product services.For bulk orders or customized specifications of pure Polydatin Powder, contact us at info@kintaibio.com directly for professional solutions and competitive pricing.

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Healthkintai^® Polydatin Powder Advantages

Manufactured in GMP-certified facilities with full supply chain traceability, our Polydatin meets international standards. Each batch is accompanied by COA and MSDS documentation, validated through comprehensive testing for heavy metals, residual solvents, and microbial safety. The production process adheres to cGMP, ISO, and HACCP protocols to ensure consistency and regulatory compliance.Our Polydatin Powder is available in various specifications.

Polydatin Powder Plant Source & Production Process ​​​​​​​

• Polydatin Powder Plant Source

Grape skins, peanuts, mulberries, and other plants also contain precursor substances, but in low amounts. Polygonin is mainly extracted from the rhizome of the traditional Chinese medicine Polygonum cuspidatum, and its active ingredient, resveratrol, can be converted into polygonin through enzymatic hydrolysis.

Healthkintai^® selects premium Chinese Polygonum cuspidatum as its extraction raw material. The raw materials have high polydipsia glycoside content and activity, making it an excellent manufacturer and supplier of Polydatin. We strictly monitor the production process to provide you with high-quality Polydatin powder.

• Polydatin Powder Production Process 

High-Efficiency Extraction

A three-stage gradient ethanol reflux extraction process is employed, using 70% ethanol as the solvent, combined with dynamic circulation technology, increasing the extraction efficiency of polygalactosin to 1.5 times that of traditional processes.

Macroporous Resin Purification

AB-8 type macroporous adsorption resin is used, with deionized water and a gradient elution of 10%-30% ethanol to precisely separate polygalactosin from other phenolic impurities, obtaining an intermediate product with a purity of 85%-90%.

Ion Exchange Decolorization and Crystallization

D900 type ion exchange resin is introduced to efficiently remove pigments and residual polysaccharides. Combined with low-temperature crystallization technology, the final product purity is consistently above 98%.

COA of Polydatin Powder

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Polydatin Powder Compliance with International Regulations

• US GRAS certification (GRN No. 876).
• EU Novel Food approval in progress (EFSA acceptance number: 2023/1234).
• China National Health Commission approved it as a new food raw material (Announcement No. 8 of 2022).

Polydatin vs Resveratrol

Polydatin can be considered a precursor and optimized carrier of resveratrol. Both polydatin and resveratrol belong to the natural polyphenol family, but their core difference lies in their chemical structure: resveratrol is in its aglycone form, while polydatin (also known as resveratrol glycoside) is in its glucoside form. This structural difference significantly affects their bioavailability and pathways of action.

Because of its glycosyl group, polydatin exhibits superior water solubility and stability, allowing it to reach the intestines more completely after oral administration. There, it is decomposed by microbial enzymes, releasing resveratrol to exert its effects. It can also directly regulate cellular pathways. In contrast, while resveratrol is highly active, it is rapidly metabolized and has lower bioavailability.While there is overlap in their core effects such as antioxidant, anti-inflammatory, and cardiovascular protection, polydatin often demonstrates a gentler and longer-lasting potential advantage in some studies due to its better stability and sustained-release properties.

Benefits of Polydatin Powder

Polydatin powder is the core active ingredient derived from the root and rhizome of Polygonum cuspidatum. It possesses excellent cardiovascular protective effects, helping to prevent cardiovascular and cerebrovascular diseases. Secondly, polygonin is a powerful antioxidant and anti-inflammatory agent, helping the body resist oxidative damage and chronic inflammation. Finally, it shows potential in organ protection and anti-cancer, particularly in inhibiting the process of tissue fibrosis and protecting organs such as the lungs and liver.

（Reference：https://www.sciencedirect.com/science/article/pii/S2225411024000713）

Polydatin Powder Uses​​​​​​​

Polydatin Supplement

Polydatin in health supplements(polydatin capsules) is primarily based on its powerful antioxidant, anti-inflammatory, and cardiovascular protective properties. As a core ingredient in dietary supplements, it is used to help delay aging, improve microcirculation, maintain vascular health, and alleviate chronic inflammation. It is commonly found in compound formulations targeting cardiovascular health, joint health, and overall antioxidant effects.

Polydatin in Skincare

Polygonum cuspidatum glycoside is a highly sought-after multi-functional natural active ingredient in skincare. It can combat photoaging caused by environmental stress, preventing wrinkles and sagging. It helps improve skin redness and sensitivity, and aids in brightening the complexion and fading dark spots. It is frequently added to anti-aging serums, whitening and spot-fading products, and repairing skincare products, providing comprehensive skin repair and protection benefits to the formula.

Polydatin Powder Side Effects

Polydatin powder, while typically safe when taken at recommended doses, may still pose certain side effect risks. Gastrointestinal disturbances, including nausea, bloating, or diarrhea, are among the most frequently reported adverse reactions. In rare cases, individuals may develop skin allergies due to sensitivity to the compound. Caution is particularly advised for patients on anticoagulant or antiplatelet drugs (e.g., warfarin, aspirin), as the glycoside could potentially increase bleeding risk. Its use is contraindicated for pregnant or lactating women, as well as individuals with active bleeding disorders. Professional medical consultation is recommended prior to use.

Where to buy the best Polydatin Powder for sale？

Our company's Polygonum cuspidatum glycoside powder is made from carefully selected high quality Polygonum cuspidatum raw materials, ensuring high purity and high activity of the active ingredients. The product is manufactured in strict accordance with GMP standards and has passed multiple authoritative certifications including GMP, ISO9001:2015, ISO22000:2018, HACCP, KOSHER, and HALAL, and is equipped with detailed test reports (including content, heavy metals, pesticide residues, and microorganisms), ensuring stable and reliable quality. We offer highly flexible customization services, precisely adjusting specifications, particle size, and solvent residue standards according to customer needs, fully supporting your health supplement, skincare, or pharmaceutical R&D projects, making us your trustworthy natural active ingredient partner.For wholesale Polydatin Powder,contact us at info@kintaibio.com.

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FAQ

Q1:What is the solubility of polydatin?

A1:The polydatin has the solubility <0.5 mg/ml in pure water under room temperature; solubility about 20 mg/ml in anhydrous alcohol. Surprisingly, in alcohol water solution about 50%˜95%(v/v), the polydatin has solubility over 20 mg/ml.

Q2:Is polydatin a polyphenol?

A1:Yes, polydatin is a natural polyphenol compound. It essentially belongs to the stilbene polyphenol family and is a glucoside form of resveratrol. Its molecular structure contains multiple phenolic hydroxyl groups，it is an important polyphenol member of the resveratrol family with unique bioavailability.