Macleaya Cordata Extract

Healthkintai^® Macleaya Cordata Extract (MCE) is derived from the pods of the Papilionaceae plant Papilion. This product utilizes targeted extraction technology to enrich total alkaloids, primarily sanguisorbin and celandine, achieving a standard content of over 60%. Extensive research and application have confirmed its broad-spectrum antibacterial, anti-inflammatory, and growth-promoting biological effects. The production process complies with international standards such as GMP,HACCP, KOSHER ensuring stable and controllable quality. It can be widely used in livestock farming and feed production, contributing to healthy animal husbandry. Please feel free to contact us at health@kintaibio.com.

• Extraction: Macleaya cordata is extracted with ethanol.
• Concentration & Dissolution: The extract is concentrated and dissolved in acidified water.
• Separation: The aqueous phase is separated.
• Basification & Precipitation: The aqueous phase is basified (e.g., with NH₄OH) to precipitate crude alkaloids.
• Isolation: Crude alkaloids are collected by centrifugation or filtration.
• Purification: Purification via silica gel chromatography.
• Final Precipitation: Sanguinarine-rich fractions are basified to precipitate pure sanguinarine.
• Collection: Pure sanguinarine is filtered and dried.​​​​​​​

1.KINTAI Macleaya Cordata Extract COA 

2.KINTAI Macleaya Cordata Extract packing details

Sanguinarine exerts its primary biological effects through multiple mechanisms, primarily targeting cellular membranes and key signaling pathways. Its core action involves intercalating into DNA, which disrupts DNA replication and transcription, leading to cell cycle arrest and apoptosis. Furthermore, sanguinarine potently inhibits the activity of the Na+/K+-ATPase pump, a critical enzyme for maintaining the cellular membrane potential. This inhibition disrupts ionic gradients and impairs essential cellular functions.

A pivotal modern mechanism is the inhibition of the Nuclear Factor-kappa B (NF-κB) signaling pathway. Sanguinarine blocks the activation and nuclear translocation of NF-κB, a master regulator of inflammation, cell survival, and proliferation. By doing so, it suppresses the expression of pro-inflammatory cytokines, anti-apoptotic proteins, and other genes crucial for cancer progression. Additionally, sanguinarine can induce the generation of reactive oxygen species (ROS), causing oxidative stress that further damages cellular components and promotes apoptotic cell death. This multi-targeted approach, affecting genetic material, membrane integrity, and vital signaling networks, underpins sanguinarine's potent antimicrobial, anti-inflammatory, and anti-cancer properties.

(Reference:https://www.sciencedirect.com/science/article/pii/S0753332224002907)

1.Anti-inflammatory and Antioxidant Effects

Sanguinarine and chelerythrine are powerful anti-inflammatory agents. They work by inhibiting the activation of the NF-κB signaling pathway, a key regulator of inflammation, thereby reducing the production of pro-inflammatory cytokines like TNF-α and IL-6. Concurrently, these alkaloids act as antioxidants, scavenging free radicals and protecting tissues from oxidative stress, which aids in faster recovery from inflammation and damage.

2.Skin Health and Cosmetic Applications

 In topical formulations, the extract's antimicrobial and anti-inflammatory properties are leveraged to treat skin conditions such as acne, dermatitis, and gingivitis. It helps reduce acne lesions by targeting the bacteria Cutibacterium acnes and calming the associated inflammation. Its use in oral care products helps control plaque-forming bacteria and maintain gum health.

3.Promotion of Intestinal Health in Animals

 In livestock and poultry production, the extract is widely used as a feed additive. It enhances gut health by modulating the intestinal microbiota, suppressing harmful bacteria while promoting beneficial ones. This action improves the integrity of the gut barrier, reduces diarrhea incidence, and enhances nutrient absorption. As a result, it improves growth performance and overall animal welfare, serving as a effective substitute for antibiotic growth promoters. 

1.Animal Feed Additives

This is the most important and widely used area for Macleaya Cordata Extract. As a natural plant extract, it is used as an alternative to antibiotic growth promoters. Its main function is to improve animal gut health by inhibiting harmful bacteria (such as Gram-positive bacteria) and promoting nutrient absorption, thereby improving the growth performance, feed conversion rate, and overall health of livestock and poultry such as pigs and chickens.

2.Veterinary Field

In animal husbandry, Macleaya Cordata Extract is used to prevent and treat bacterial intestinal diseases, such as swine dysentery. Its strong antibacterial and anti-inflammatory properties help control infections, reduce the incidence of diarrhea, lower medical costs in the breeding process, and avoid the problem of chemical drug residues.

3.Sanguinarine for mouthwash

Sanguinarine has significant applications in oral care. With its broad-spectrum and potent antibacterial properties, it effectively inhibits major pathogens causing plaque and gingivitis (such as Streptococcus). Therefore, it is widely added to products such as toothpaste and mouthwash, with its core functions being to reduce plaque formation, alleviate gingivitis, and improve overall oral health. Its natural origin also makes it an ideal alternative to chemical antibacterial agents.

The use of antibiotics in livestock and poultry feed is mainly for the prevention and treatment of diseases and the promotion of livestock and poultry growth, thus driving the rapid development of the livestock and poultry breeding industry. However, the long-term abuse of antibiotics has led to increased drug resistance in animal-derived bacteria, and drug resistance genes threaten human health through meat product residues, fecal excretion, and other pathways. With the advent of the era of antibiotic ban in livestock and poultry feed, the development of safe and effective antibiotic alternatives is particularly important for improving the growth performance and production efficiency of livestock and poultry.

Macleaya Cordata Extract has a positive effect on improving the muscle quality and intestinal metabolism of broilers. It is widely used in livestock and poultry production, but the amount added varies in different animal species. Domestic and foreign research reports on Borax in livestock and poultry are mostly focused on broilers, but the application effects vary slightly depending on the broiler breed and age. Adding Macleaya Cordata Extract to the diet can significantly improve the growth retardation of broilers caused by necrotic enteritis, enhance their immune function, and thus promote growth.

(Reference：Effects of Macleaya Cordata Extract on growth performance, antioxidant function and meat quality of broiler chickens）​​​​​​​