Hydrochloride Berberine

Product Details

KINTAI, a renowned high-tech biotechnological manufacturer in China with over a decade of contributions to the global health industry, excels in hydrochloride berberine production. It holds a range of prestigious certifications, including ISO 9001, ISO 22000, HACCP, Kosher, Halal, a high-tech enterprise certification, and has completed US FDA registration, all reflecting its commitment to quality and safety.

KINTAI offers hydrochloride berberine with high purity levels (97% and 98% verified by HPLC) as a light yellow crystalline powder, soluble in water but not in benzene, ether, or chloroform, with packaging options of 1 kg/foil bag and 20 kg/drum to meet diverse customer needs. Distinguishing itself from competitors, KINTAI operates a 12,000 ㎡ GMP-compliant factory with 100,000-level clean workshops, ensuring a low-contamination production environment; its products are non-additive, non-GMO, non-irradiated, with only heat treatment used in some cases, making them a healthier and more natural choice. In terms of international standards, KINTAI's hydrochloride berberine complies with relevant ones, such as ISO standards, which are globally recognized for strict quality and safety, allowing seamless integration into various industries worldwide, including pharmaceuticals and health foods, even though the compound is involved in areas like pesticides and agrochemicals in international classifications.​

 What is hydrochloride berberine? 

Hydrochloride berberine, also known as berberine hydrochloride, is a salt form of berberine, an alkaloid found in various plants such as Coptis chinensis, Berberis vulgaris, and Hydrastis canadensis. It is widely recognized for its diverse biological activities and has been used in traditional medicine for centuries, particularly in Chinese and Ayurvedic practices, to address a range of health issues.​

Chemically, hydrochloride berberine typically appears as a light yellow crystalline powder. It has specific solubility properties, being soluble in water while insoluble in organic solvents like benzene, ether, and chloroform. Its purity is often measured using high-performance liquid chromatography (HPLC), with common purity levels being 97% and 98%, ensuring its quality for various applications.​

In terms of functionality, hydrochloride berberine exhibits antimicrobial properties, making it effective against certain bacteria, fungi, and protozoa. It also has been studied for its potential in regulating blood sugar and lipid levels, supporting digestive health, and possessing anti-inflammatory effects. These properties have led to its use in pharmaceuticals, dietary supplements, and even some cosmetic products.​

Due to its biological activities and potential health benefits, hydrochloride berberine has gained attention in the global market. Manufacturers adhere to strict quality standards and obtain relevant certifications to ensure its safety and efficacy, making it a valuable ingredient in various industries focused on health and wellness.

 Hydrochloride Berberine Sources 

As a plant extraction company, KINTAI specializes in deriving hydrochloride berberine exclusively from natural plant sources, leveraging the rich berberine content in specific botanical species.​

One primary source is Coptis chinensis, a revered herb in traditional Chinese medicine. The roots and rhizomes of this plant are abundant in berberine, which serves as the raw material for extracting and processing into hydrochloride berberine. Through meticulous extraction techniques, KINTAI ensures that the valuable alkaloid is efficiently obtained from Coptis chinensis while preserving its natural properties.​

Berberis vulgaris, commonly called barberry, is another key plant source. This shrub’s bark, roots, and even fruits contain notable amounts of berberine. KINTAI taps into these parts of the plant, utilizing advanced extraction methods to isolate berberine, which is then converted into its hydrochloride form. The company’s expertise in handling such plant materials guarantees a high-quality extraction process.​

Hydrastis canadensis, or goldenseal, native to North America, is also a significant source. With a long history of use in traditional medicine, this plant’s berberine-rich components are carefully extracted by KINTAI. The extraction process is designed to maintain the integrity of the berberine, ensuring that the resulting hydrochloride berberine meets the strict standards set by the company.​

Coptis chinensis                                                        Berberis vulgaris                                                                Hydrastis canadensis

By focusing solely on plant extraction, KINTAI harnesses the natural power of these plants, providing hydrochloride berberine that is closely linked to traditional medicinal practices and valued for its natural origin.​

 Hydrochloride Berberine Specification 

 Hydrochloride Berberine Manufacture Process 

 Hydrochloride Berberine COA 

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Hydrochloride Berberine Benefits 

Supports Metabolic Health： Hydrochloride berberine is well-known for its potential to regulate blood sugar levels. It can improve insulin sensitivity, helping cells better absorb and utilize glucose, which is beneficial for individuals with type 2 diabetes or those at risk of developing insulin resistance. Additionally, it may aid in weight management by regulating lipid metabolism, reducing the accumulation of triglycerides and cholesterol in the body, thereby supporting overall metabolic balance.​

Exhibits Antimicrobial and Anti-Inflammatory Properties： This compound has broad-spectrum antimicrobial effects, inhibiting the growth of various bacteria, fungi, and some parasites. It works by disrupting the microbial cell membrane and interfering with their metabolic processes. While it can reduce inflammation by suppressing the production of pro-inflammatory cytokines, which helps alleviate inflammatory responses in conditions like gastrointestinal infections or skin inflammations.​

Promotes Cardiovascular Health： Hydrochloride berberine may contribute to maintaining healthy blood lipid levels. It can lower levels of low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol, and triglycerides, while potentially increasing high-density lipoprotein (HDL) cholesterol, the "good" cholesterol. By doing so, it helps reduce the risk of atherosclerosis and other cardiovascular diseases. Moreover, it may have a mild blood pressure-lowering effect, supporting overall heart function.​

Aids Gastrointestinal Regulation： It plays a role in supporting a healthy gut microbiota. By inhibiting harmful bacteria in the gut and promoting the growth of beneficial ones, it helps maintain the balance of the intestinal flora. This balance is crucial for proper digestion and nutrient absorption. Additionally, hydrochloride berberine can alleviate symptoms of certain gastrointestinal disorders, such as diarrhea caused by bacterial infections, by reducing intestinal inflammation and regulating intestinal motility.​

 Hydrochloride Berberine Applications 

Medical Applications in Metabolic Disorders：Hydrochloride berberine is commonly used as an adjuvant therapy in managing type 2 diabetes. It helps regulate blood glucose levels by improving insulin sensitivity and inhibiting glucose absorption in the intestines, often prescribed alongside conventional antidiabetic drugs to enhance efficacy. Additionally, it finds application in addressing dyslipidemia, as it can lower elevated cholesterol and triglyceride levels, supporting the treatment of metabolic syndrome.​

Antimicrobial Use in Infectious Diseases：Due to its broad-spectrum antimicrobial properties, hydrochloride berberine is applied in treating various infections. It is effective against bacterial gastrointestinal infections (such as those caused by E. coli or Salmonella), fungal infections like candidiasis, and even some parasitic infestations. In clinical settings, it may be used topically to treat skin infections or orally for systemic infections, particularly in cases where antibiotic resistance is a concern.​

Complementary Role in Cardiovascular Care：In cardiovascular health management, hydrochloride berberine is used as a complementary agent. It aids in lowering mild to moderate hypertension by promoting vascular relaxation and regulating blood vessel function. Moreover, its ability to reduce LDL cholesterol and prevent arterial plaque buildup makes it useful in supporting the prevention and management of atherosclerosis, often as part of a comprehensive cardiovascular health plan.​

Applications in Veterinary and Agricultural Sectors：Beyond human health, hydrochloride berberine is utilized in veterinary medicine to treat gastrointestinal infections in livestock and poultry, such as diarrhea in pigs or chickens caused by bacterial pathogens. In agriculture, it is sometimes incorporated into feed additives to promote animal growth and improve gut health, thanks to its antimicrobial and anti-inflammatory properties that help maintain a balanced intestinal microbiota in animals.

Berberine HCL vs Berberine Phytosome

While berberine phytosome shines with enhanced bioavailability, berberine HCl holds distinct advantages that make it a enduring choice. First, its extensive research backing is unparalleled—decades of studies validate its efficacy across metabolic health (blood sugar and lipid regulation), antimicrobial activity, and cardiovascular support, providing clear, evidence-based guidance for use. Second, it offers cost-effectiveness: as a straightforward, widely produced formulation, it is significantly more affordable than phytosome versions, making consistent supplementation accessible to broader populations, including those managing long-term health regimens on a budget. Additionally, berberine HCl’s well-understood pharmacokinetics (even with lower bioavailability) allow for predictable dosing adjustments; healthcare providers and users alike are familiar with its absorption patterns, enabling precise titration to achieve desired effects. Finally, its versatility in applications—from oral supplements to topical formulations for skin issues—stems from its stability in various delivery systems, a trait that remains valuable despite the phytosome’s absorption edge. For many, these factors make berberine HCl a practical, reliable foundation for supplementation.

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 Berberine HCL vs Dihydroberberine 

Compared to dihydroberberine—a reduced form of berberine often marketed for higher bioavailability—berberine HCl retains key advantages that solidify its role as a trusted staple. Foremost, its robust scientific foundation is unmatched: decades of clinical and preclinical research have rigorously validated its efficacy across a broad spectrum of uses, from blood sugar regulation and lipid management to antimicrobial and anti-inflammatory effects. This extensive body of evidence provides clear, actionable insights for both healthcare providers and users, ensuring confidence in its therapeutic potential.​

Additionally, berberine HCl offers versatility in application that dihydroberberine, still in earlier stages of study, has yet to match. It is widely used in both oral supplements and topical formulations (e.g., for skin conditions), leveraging its stability and well-characterized properties. Its affordability is another key edge: as a mature, mass-produced compound, it is significantly more cost-effective than dihydroberberine, making consistent supplementation accessible to a broader range of individuals, including those managing long-term health goals on a budget.​

While dihydroberberine may boast higher absorption rates, berberine HCl’s proven track record, diverse utility, and cost efficiency make it a practical, reliable choice for most users seeking its well-documented benefits.

 Why choose KINTAI Hydrochloride Berberine 

1. We promise that our raw materials are naturally grown without any additives.
2. We provide customized extraction solutions to produce Hydrochloride Berberine powder in various specifications tailored to your requirements.
3. Our production facilities hold internationally recognized certifications, including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.

About Us

 OEM and ODM Services 

KINTAI is a professional pro-xylane manufacturer and supplier. We offer OEM and ODM services to take care of the particular necessities and prerequisites of our clients. Our group of specialists can foster modified items and offer coordinated support arrangements.

 Our Certifications 

KINTAI Advantages

Parcel and Shipping

1> 1KG/bag, 10KG/carton,25kg/drum
2> By Express: Door to door; DHL/FEDEX/EMS; 3-4DAYS; Suitable for under 50kg; high cost; easy to pick up the goods
3> By Air: Airport to Airport; 4-5 days; Suitable for more than 50kg; high cost;professional broker needed
4> By Sea: Port to Port; 15-30days; Suitable for more than 500kg; Low cost; professional broker needed

Please contact KINTAI at info@kintaibio.com for your Hydrochloride Berberine needs. We look forward to serving you!