High - Purity Chlorogenic Acid Powder 

Product Details

China Manufacturers Best Suppliers supply chlorogenic acid powder for sale.

Xi'an Kintaihealth® emerges as a distinguished manufacturer of High-Purity Acid Chlorogenic Powder (CAS: 327-97-9). Leveraging advanced extraction and purification technologies, we offer pharmaceutical-grade products, ensuring chlorogenic acid retains its maximum bioactivity and stability. Our high-purity powder, with a minimum purity of 98%, undergoes stringent quality control at every production stage, guaranteeing consistent excellence in both purity and efficacy.This chlorogenic acid powder is characterized by its fine, uniform crystalline structure and superior solubility, facilitating seamless integration into diverse formulations. Thanks to its high bioavailability, it delivers enhanced performance across multiple industries. Whether utilized in the development of functional foods, dietary supplements, pharmaceutical preparations, or cosmetic products, our high-purity chlorogenic acid powder provides reliable support for creating premium-quality end products. Trust Xi'an Kintaihealth® for all your high-purity chlorogenic acid powder needs, and experience the difference in quality and performance.

 What is Acid Chlorogenic powder？

Chlorogenic acid powder is a natural botanical extract derived from various plant sources, such as coffee beans, honeysuckle flowers, and Eucommia ulmoides leaves. Renowned for its potent bioactive properties, it has become a valuable ingredient in multiple industries.

Chemically, chlorogenic acid is a polyphenol with strong antioxidant capabilities. It effectively neutralizes free radicals, helping to combat oxidative stress in the body, which is linked to aging, inflammation, and various chronic diseases. Additionally, it exhibits anti-inflammatory effects and has been studied for its potential in regulating blood sugar levels, improving lipid metabolism, and supporting cardiovascular health.

In the nutraceutical and dietary supplement sectors, chlorogenic acid powder is often used to formulate products aimed at promoting overall well-being and preventing diseases. In the food industry, it functions as a natural antioxidant preservative, extending the shelf life of products while enhancing their nutritional value. The pharmaceutical industry explores its therapeutic potential for developing drugs, and in cosmetics, it is added to skincare products for its anti-aging and skin - protecting benefits. With its diverse applications and health - promoting properties, chlorogenic acid powder continues to gain prominence in the global market.

Kintai's High-Purity Chlorogenic Acid Powder (CAS: 327-97-9) achieves pharmaceutical-grade purity (≥98% by HPLC), ensuring maximum potency. Key benefits include:

· Powerful Antioxidation: Scavenges free radicals with an IC₅₀ value ≤15 μM, protecting cells from oxidative damage.

· Metabolic Regulation: Clinically studied to support healthy blood sugar and lipid levels, aiding in metabolic health research.

· Enhanced Bioactivity: Its high purity allows for better interaction with biological pathways, delivering superior efficacy compared to lower-grade alternatives.

Multi-Industry Applications

· Nutraceuticals & Supplements: Ideal for capsules (100 - 300mg per serving), tablets, and functional beverages, providing consumers with natural health benefits.

· Pharmaceuticals: Used as an active ingredient in medications targeting cardiovascular health, inflammation, and metabolic disorders, with typical oral dosages of 200 - 500mg per day.

· Food Industry: Added to processed foods as an antioxidant preservative (0.05 - 0.2g/kg) and in functional snacks for nutritional enhancement.

· Cosmetics: Incorporated into creams, serums (0.5 - 2%), and masks for anti-aging, anti-inflammatory, and skin-brightening effects.

Strict Quality Control

· Purity Assurance: HPLC-verified ≥98% purity, with heavy metals controlled within strict limits (Pb≤2ppm, As≤1ppm) and solvent residues compliant with international standards.

· Stability: Maintains stability under diverse conditions, with a shelf life of 24 months at 40℃/75% RH.

· Compliance: Manufactured in GMP-certified facilities, accompanied by COA/MSDS documents, and meeting FDA, EFSA, and WHO regulatory requirements.

 Chlorogenic acid Production Process

I. Raw Material Selection and Pretreatment

Raw Material Collection
Chlorogenic acid is commonly found in plants such as honeysuckle flowers, Eucommia ulmoides leaves, and walnut flowers. Always choose fresh, pest - free plant materials. For example, honeysuckle is best harvested during its blooming period.

Pretreatment
Clean the materials thoroughly, then cut or grind them (e.g., grind Eucommia ulmoides leaves into fine powder). This increases the surface area and improves extraction efficiency. Some processes suggest storing the materials below 4°C to prevent degradation.

II. Extraction Processes

1. Solvent Extraction

· Ethanol Reflux Extraction (Chinese Pharmacopoeia Method)
Use a 70% ethanol solution with a solid - to - liquid ratio of 1:10 to 1:15. Heat in two steps: first, extract with 60% of the solvent at 80°C for 1.5 hours, then use the remaining 40% solvent for another 1 hour. This method can achieve an extraction rate of over 85%. Stir at around 80 revolutions per minute to help dissolve the acid.

· Methanol Extraction
When extracting from Eucommia ulmoides leaves, react with methanol at room temperature for 96 hours, followed by acid treatment.

2. Assisted Extraction Techniques

· Ultrasonic - Assisted Extraction
Combine polyethylene glycol (PEG - 200) with enzyme - assisted ultrasound (EAUE). The best conditions are 42% PEG, 49°C, and pH 4.2, reaching an extraction rate of 6.955%—better than traditional heat reflux methods. In walnut flower extraction, ultrasonic - assisted ethanol extraction can get chlorogenic acid, neochlorogenic acid, and cryptochlorogenic acid at the same time.

· Microwave - Assisted Extraction
A patented method combines microwave soaking and hydrothermal extraction, along with two - phase extraction (using petroleum ether and ethyl acetate) to remove impurities. After purification, the chlorogenic acid purity can reach over 98%.

III. Concentration and Purification

Initial Concentration
Filter the extract with double - layer filter paper or an ultrafiltration membrane. Then, use a rotary evaporator to concentrate it under reduced pressure (at - 0.08MPa and ≤60°C) until it’s about 1/3 of its original volume.

Membrane Separation

· Ultrafiltration membranes remove large molecules like polysaccharides and proteins, keeping the small chlorogenic acid molecules.

· Nanofiltration membranes further concentrate the filtered liquid, increasing the purity and amount of chlorogenic acid.

Extraction and Crystallization
Extract with ether or ethyl acetate under acidic conditions, then adjust the pH to form crystals. For example, when extracting from Eucommia ulmoides leaves, use concentrated sulfuric acid and sodium hydroxide to adjust the pH. Using gradient ethanol elution or multi - stage purification (like the staged elution in patents) can improve the purity of the crystals.

IV. Process Optimization

· Enzyme - Assisted Extraction: Using chlorogenic acid enzymes can boost the extraction rate from Eucommia ulmoides leaves.

· Response Surface Methodology: Adjust variables like temperature, ethanol concentration, and solid - to - liquid ratio to get higher yields.

· Combined Extraction: Co - extract chlorogenic acid and total flavonoids to make better use of resources.

 Acid Chlorogenic powder Benefits

Chlorogenic acid powder offers a range of notable benefits, making it a sought-after ingredient across multiple fields:

1. Antioxidant Protection: As a powerful antioxidant, chlorogenic acid powder helps neutralize free radicals in the body. By reducing oxidative stress, it may slow down cellular aging, protect against DNA damage, and lower the risk of chronic diseases like heart disease, cancer, and neurodegenerative disorders.

2. Metabolic Health Support: Studies suggest that chlorogenic acid can help regulate blood sugar levels by inhibiting the breakdown of carbohydrates, thus reducing glucose absorption. It may also aid in improving lipid metabolism, lowering bad cholesterol (LDL) levels, and promoting a healthy weight by increasing fat oxidation.

3. Anti-inflammatory Effects: It exhibits anti-inflammatory properties, which can help soothe inflammation in the body. This makes it beneficial for managing conditions associated with chronic inflammation, such as arthritis, inflammatory bowel disease, and certain skin disorders.

4. Heart Health Promotion: By reducing oxidative stress and inflammation, chlorogenic acid contributes to cardiovascular health. It may help lower blood pressure, improve blood vessel function, and prevent the formation of blood clots, all of which are crucial factors in maintaining a healthy heart.

5. Cognitive Function Enhancement: Some research indicates that chlorogenic acid may cross the blood-brain barrier and provide neuroprotective benefits. It could potentially improve cognitive function, enhance memory, and reduce the risk of age-related cognitive decline and neurodegenerative diseases like Alzheimer’s and Parkinson’s.

6. Skin Health Improvement: When used in skincare products or consumed orally, its antioxidant and anti-inflammatory properties can protect the skin from UV damage, environmental pollutants, and premature aging. It may help reduce wrinkles, improve skin texture, and promote a more youthful complexion.

· Formulations: Used in capsules, tablets, or powders (50–300mg/serving) for antioxidant supplements, weight management products, or metabolic health support.

· Example: Blended into “blood sugar control” supplements with other herbs like cinnamon or bitter melon.

2. Functional Food & Beverage

· Antioxidant Additive: Added to sports drinks (0.1–0.5g/L), energy bars, or plant-based milks to extend shelf life and enhance nutritional value.

· Natural Preservative: Substitutes synthetic antioxidants (e.g., BHA/BHT) in baked goods or snacks (0.05–0.2g/kg).

3. Pharmaceutical Research & Development

· Active Pharmaceutical Ingredient (API): Investigated for oral medications targeting type 2 diabetes (200–500mg/day clinical trials) or anti-inflammatory therapies.

· Topical Formulations: Used in creams or gels for skin conditions like acne or eczema, leveraging its anti-inflammatory properties.

4. Cosmetics & Skincare

· Anti-Aging Products: Incorporated into serums (0.5–2%), masks, or moisturizers to fight free radicals and reduce fine lines.

· Sensitive Skin Care: Added to cleansers or toners for soothing effects, suitable for rosacea or irritated skin.

5. Agriculture & Animal Feed

· Feed Additive: Mixed into livestock feed (10–20mg/kg) to boost immunity, improve gut health, or act as a natural growth promoter.

· Crop Protection: Studied for use in plant extracts as a natural pesticide due to its antibacterial properties.

6. Food & Beverage Industry (Other Roles)

· Beverage Clarification: Used in tea or coffee extracts to prevent sediment formation.

· Color Stabilizer: Maintains the hue of fruit juices or jams by inhibiting enzymatic browning.

7. Chemical & Industrial Applications

· Laboratory Reagent: Serves as a standard compound in HPLC analysis for plant extract quality control.

· Polymer Additive: Used in biodegradable plastics for antioxidant properties (research - based application).

  Safety of KINTAI’S Acid Chlorogenic powder  

Toxicological Considerations

KINTAI’s chlorogenic acid powder has undergone extensive toxicological testing. Studies indicate low acute toxicity, with no significant adverse effects reported at normal usage levels. Its natural origin from plants like coffee beans and honeysuckle further supports its safety profile when consumed within recommended dosages.

Quality Control & Safety Certifications

Manufactured in GMP-certified facilities, the powder meets strict quality control standards. HPLC-verified purity of ≥98% ensures consistent quality, while heavy metal levels (Pb≤2ppm, As≤1ppm) and microbial counts comply with international norms. It holds certifications conforming to FDA, EFSA, and WHO safety requirements.

Safety Warnings & Limitations

Avoid excessive intake, as high doses may cause mild gastrointestinal discomfort in sensitive individuals. Pregnant or breastfeeding women should consult a healthcare professional before use. The powder is for industrial and research use; direct human consumption should follow formulation guidelines.

Why Choose Acid Chlorogenic powder by Kintainutri®?

1. We promise that our raw materials are naturally grown without any additives.
2. We provide customized extraction solutions to produce Chlorogenic acid powder in various specifications tailored to your requirements.
3. Our production facilities hold internationally recognized certifications including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.

OEM and ODM Services

KINTAI is a professional dihydroquercetin powder manufacturer and supplier. We offer OEM and ODM administrations to take care of the particular necessities and prerequisites of our clients. Our group of specialists can foster modified items and offer coordinated support arrangements.

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About KINTAI

KINTAI is a leading manufacturer and supplier of Dihydroquercetin. We have a cutting-edge innovative workplace, creation offices, and hardware. Our obligation to quality is clear through our broad scope of licenses and confirmations. We offer customized products, providing integrated solutions and fast delivery with secure packaging.

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