Tripterygium Wilfordii Root Extract

Product Details

 What Is Tripterygium Wilfordii Root Extract 

Tripterygium wilfordii root extract, derived from the roots of the Tripterygium wilfordii plant (a traditional Chinese medicinal herb), is a natural botanical extract rich in bioactive compounds—most notably tripterine (also known as celastrol), along with diterpenoids, triterpenoids, and alkaloids. Renowned for its potent biological activities, this extract has been utilized in traditional medicine for centuries and is now widely processed into powder form for modern applications.

Healthkintai® Tripterygium wilfordii root extract powder retains the core active components of the raw herb, offering stability, easy handling, and versatile integration into various formulations. Its unique properties make it a valuable ingredient in pharmaceutical research, nutraceutical development, and specialized skincare, leveraging its well-documented anti-inflammatory and immunomodulatory effects.

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 Production Process Of  Tripterygium Wilfordii Root Extract 

Extraction Process of Tripterine Powder​

The extraction of tripterine powder, a bioactive component derived from Tripterygium wilfordii root, involves a series of precise steps to ensure purity, potency, and safety. Below is a detailed breakdown of the process:​

Raw Material Selection and Preparation​

High-quality Tripterygium wilfordii roots are harvested at optimal maturity, typically from sustainably sourced or cultivated plants. The roots are thoroughly cleaned to remove soil, debris, and impurities, then dried under controlled temperature conditions (35–45°C) to reduce moisture content (to less than 10%). This step ensures the stability of active compounds and prevents microbial growth.​

Crushing and Sieving​

The dried roots are crushed into coarse particles using a pulverizer, then sieved through a 20–40 mesh sieve to achieve uniform particle size. This increases the surface area, facilitating efficient solvent penetration in subsequent extraction.​

Solvent Extraction​

The crushed root particles are subjected to solvent extraction, commonly using ethanol (70–80% concentration) as the extraction solvent—chosen for its ability to dissolve tripterine and other lipophilic active compounds while minimizing the extraction of unwanted hydrophilic impurities. The mixture is heated under reflux at 60–70°C for 2–3 hours, with periodic stirring. This process is repeated 2–3 times to maximize the yield of active ingredients.​

Filtration and Concentration​

After extraction, the mixture is filtered through a Buchner funnel or filter cloth to separate the liquid extract from the solid residue. The filtrate (crude extract) is then concentrated using a rotary evaporator under reduced pressure (at 50–60°C) to remove ethanol, resulting in a thick, semi-solid extract paste.​

Purification​

To isolate tripterine, the concentrated paste undergoes purification. It is redissolved in a small volume of ethanol, then mixed with silica gel (as an adsorbent) and dried to form a powder. This powder is loaded onto a silica gel column for column chromatography, with a gradient elution solvent system (e.g., chloroform-ethanol mixtures) to separate tripterine from other compounds. Fractions containing tripterine are identified via thin-layer chromatography (TLC) or high-performance liquid chromatography (HPLC) and combined.​

Drying and Micronization​

The purified tripterine-rich solution is concentrated again to remove residual solvents, then freeze-dried or spray-dried (at low temperatures to preserve activity) to obtain a dry crystalline powder. The powder is further micronized using a superfine grinder to achieve a particle size of 80–100 mesh, ensuring uniform dispersion and solubility in various formulations.​

Quality Testing​

The final tripterine powder undergoes rigorous quality testing, including HPLC analysis to verify tripterine content (typically ≥98% for high-purity products), heavy metal detection (to meet ≤10 ppm standards), microbial limit tests, and residual solvent checks (ensuring compliance with international safety regulations). Only batches passing these tests are approved for packaging and distribution.​

This standardized process ensures that the tripterine powder retains its biological activity while meeting strict quality and safety criteria, making it suitable for pharmaceutical, research, and specialized industrial applications.

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 COA Of Tripterygium Wilfordii Root Extract 

 Safety Of Tripterygium Wilfordii Root Extract 

Toxicity Profile and Potential Risks​

Tripterygium wilfordii root extract contains bioactive compounds like tripterine (celastrol) and diterpenoids, which exhibit potent biological activity but also inherent toxicity. High doses or improper use can lead to adverse effects, including hepatotoxicity (liver damage), nephrotoxicity (kidney impairment), and gastrointestinal issues (nausea, vomiting, diarrhea). Additionally, it may cause reproductive toxicity, such as reduced fertility or hormonal disruptions, particularly in prolonged use. These risks highlight the need for strict dosage control and professional supervision.​

Safety in Controlled Applications​

When used under regulated conditions—such as in pharmaceutical formulations with standardized dosages or in cosmetic products with highly diluted concentrations—risks can be mitigated. Clinical studies and decades of traditional use have established safe thresholds for therapeutic applications, especially in treating autoimmune diseases where benefits often outweigh controlled risks. Proper processing (e.g., purification to remove excessive toxic impurities) further enhances safety, ensuring the extract retains efficacy while minimizing harmful components.​

Quality Control and Regulatory Compliance​

Safety is heavily dependent on rigorous quality control throughout production. Reputable manufacturers adhere to strict standards, including testing for heavy metal contaminants (≤10 ppm), residual solvents (below international safety limits), and microbial purity. Compliance with regulatory bodies (e.g., FDA, EMA, or local health authorities) ensures that extracts meet safety benchmarks for their intended use—whether in pharmaceuticals, research, or cosmetics. Clear labeling of usage instructions and contraindications (e.g., for pregnant individuals or those with liver/kidney conditions) is also critical to prevent misuse.​

 Where To Buy Tripterygium Wilfordii Root Extract 

When it comes to purchasing Tripterygium Wilfordii Root Extract, choosing Healthkintai® offers a multitude of distinct benefits.​

Unparalleled Quality Assurance​

Healthkintai® sources Tripterygium Wilfordii roots from carefully selected, sustainable plantations. Our team of experts monitors the growth environment to ensure that the plants are free from contaminants such as heavy metals and pesticides. During the extraction process, state-of-the-art technology is employed. We use advanced solvent extraction methods followed by multi-step purification techniques, including high-performance column chromatography. This results in an extract with a consistently high purity of active ingredients, such as tripterine. Rigorous in-house quality control tests are conducted at every stage, and our products are also independently tested by third-party laboratories to meet international standards for purity, microbial limits, and heavy metal content.​

Customization Options​

Understanding that different industries have diverse requirements, Healthkintai® provides extensive customization services. Whether you need the extract in a specific powder particle size for better solubility in pharmaceutical formulations or a particular concentration of active compounds for research purposes, our R & D team can work with you to develop a tailored solution. We can also customize packaging, offering options from small sample vials for initial evaluations to large bulk containers for industrial-scale applications, ensuring that the product is well-protected during storage and transportation.​

Exceptional Customer Support​

At Healthkintai®, we pride ourselves on our customer service. Our knowledgeable sales representatives are available around the clock to answer any questions you may have regarding the product, its applications, or the ordering process. We offer detailed product information sheets, including comprehensive safety data sheets, to help you make informed decisions. For customers new to Tripterygium Wilfordii Root Extract, we provide educational resources on its properties and potential uses. Moreover, our after-sales support is second to none. We follow up with customers to ensure their satisfaction with the product and are always ready to address any concerns promptly, making the buying experience seamless and stress-free.​

 Kintai Tripterygium Wilfordii Root Extract Benefits 

Potent Bioactive Efficacy for Targeted Applications​

Kintai’s Tripterygium Wilfordii Root Extract is rich in key active compounds like tripterine, which deliver robust anti-inflammatory and immunomodulatory effects. This makes it highly valuable for pharmaceutical research and development, particularly in formulating solutions for autoimmune disorders (e.g., rheumatoid arthritis) and chronic inflammatory conditions. Its natural composition ensures it interacts effectively with biological pathways, offering a reliable foundation for therapeutic innovations while maintaining the potency needed for meaningful results.​

Versatile Adaptability Across Industries​

Beyond pharmaceuticals, this extract’s unique properties make it a versatile ingredient across sectors. In cosmetics, its anti-inflammatory traits support formulations for sensitive or problematic skin, helping to soothe irritation and balance skin health. For nutraceutical and research fields, its standardized composition—achieved through Kintai’s precise extraction processes—ensures consistent performance, whether used in lab studies or specialized health products. This adaptability allows businesses to integrate it into diverse workflows with confidence.​

Reliable Quality for Safe, Consistent Outcomes​

Backed by Kintai’s rigorous quality control protocols, the extract guarantees exceptional purity and safety. With third-party verified low levels of contaminants and standardized active ingredient concentrations, it minimizes risks associated with impurities, ensuring compliance with global regulatory standards. This reliability not only simplifies integration into production processes but also provides end-users—from researchers to manufacturers—with the assurance of consistent, reproducible results, reducing variability and enhancing trust in the final product.​

Interested? We'd love to send you a free Sample!

 Tripterygium Wilfordii Root Extract Applications 

Pharmaceutical and Therapeutic Development​

Kintai’s extract is a key raw material in pharmaceutical research and production, particularly for formulating treatments for autoimmune and inflammatory conditions. Its high concentration of tripterine and other bioactive compounds enables the development of drugs targeting rheumatoid arthritis, systemic lupus erythematosus, and psoriasis, where its anti-inflammatory and immunomodulatory properties help alleviate symptoms and regulate overactive immune responses. Additionally, it supports the creation of specialized formulations for chronic pain management, leveraging its ability to reduce inflammation-driven discomfort.​

Cosmetics and Skincare Formulations​

In the cosmetics industry, this extract is integrated into skincare products designed for problematic or sensitive skin. Its natural anti-inflammatory properties make it effective in soothing redness, irritation, and acne-related inflammation, while its ability to balance skin’s immune response helps strengthen the skin barrier. Kintai’s standardized extraction ensures consistent potency, allowing formulators to create serums, creams, and masks that address conditions like eczema or rosacea without compromising safety—ideal for brands focusing on science-backed, gentle skincare solutions.​

Academic and Industrial Research​

The extract serves as a valuable tool in biomedical and life sciences research. Its well-characterized composition makes it a reliable subject for studying immunology, inflammation pathways, and natural product pharmacology, aiding in the discovery of new therapeutic targets or mechanisms of action. Industrial research labs also use it to test formulations for nutraceuticals or veterinary products, leveraging Kintai’s quality-assured extract to ensure reproducibility in experiments and pilot studies—critical for advancing innovations in health and wellness applications.

 OEM and ODM Services 

KINTAI is a professional Tripterine Powder manufacturer and supplier. We offer OEM and ODM administrations to take care of the particular necessities and prerequisites of our clients. Our group of specialists can foster modified items and offer coordinated support arrangements.

 Our Certifications 

 About KINTAI 

KINTAI is a leading manufacturer and supplier of Tripterine Powder. We have a cutting-edge innovative workplace, creation offices, and hardware. Our obligation to quality is clear through our broad scope of licenses and confirmations. We offer customized products, providing integrated solutions and fast delivery with secure packaging.

 KINTAI's Procession 

 Packing And Shipping