Salvia Miltiorrhiza Extract Salvianolic Acid B Powder

Salvia miltiorrhiza extract is an enriched product of active ingredients extracted from the dried roots and rhizomes of the plant Salvia miltiorrhiza, belonging to the Lamiaceae family. Its main active substances include fat-soluble tanshinones (such as tanshinone IIA and cryptotanshinone) and water-soluble salvianolic acids (such as salvianolic acid B and rosmarinic acid). Modern pharmacological studies have shown that this extract has significant cardiovascular protective effects, capable of dilating coronary arteries, improving myocardial ischemia, inhibiting platelet aggregation, and reducing blood viscosity. It also possesses anti-inflammatory, antioxidant, anti-fibrotic, and neuroprotective activities. It is one of the most widely used Chinese herbal extracts in the field of integrated traditional Chinese and Western medicine.Buy Salvia miltiorrhiza extract powder,contact us at info@kintaibio.com.

Healthkintai^®'s Salvia Miltiorrhiza Extract raw materials come from Sichuan, a famous Danshen producing area in China. Sichuan has multiple advantages as a Danshen raw material producing area. The unique purple soil and climate conditions in Sichuan result in Danshen with significantly higher levels of active ingredients such as tanshinone and salvianolic acid B than the pharmacopoeia standards, ensuring excellent quality. Sichuan has a history of Danshen cultivation for hundreds of years, with standardized operating procedures from seed selection and field management to harvesting and processing, ensuring the stability and traceability of raw materials. In addition, Sichuan Danshen generally has a high content of salvianolic acid, making it particularly suitable for extracting water-soluble salvianolic acid components, meeting the production requirements of Salvia Miltiorrhiza Extract powder.

The production process of Salvia miltiorrhiza extract typically includes the following steps: First, the Salvia miltiorrhiza rhizome is cleaned, cut, and crushed; then, the fat-soluble tanshinone components are extracted by ethanol reflux followed by water extraction, and the water-soluble salvianolic acid components are extracted by decocting the residue with water; the two extracts are filtered, concentrated under reduced pressure, and then combined; finally, the powder is prepared by spray drying or vacuum freeze drying, and then crushed, sieved, and sealed in packaging to obtain the finished product.

Salvianolic acid B exhibits good water and organic solvent solubility. It is soluble in water, with its solubility significantly affected by pH; under acidic conditions combined with ultrasound assistance, the solubility can reach 25-50 mg/mL; its solubility in pure water is approximately 5 mg/mL. In organic solvents, salvianolic acid B is soluble in methanol and ethanol, and its solubility in dimethyl sulfoxide (DMSO) is approximately 20-25 mg/mL. Furthermore, this compound is also soluble in acetonitrile, but its solubility in oily solvents is poor.

cardiovascular effects of salvianolic acid b

Salvianolic acid B exhibits significant multi-target protective effects on the cardiovascular system. In terms of anti-atherosclerosis, it reduces atherosclerotic plaque area, lipid deposition, and inflammatory responses by inhibiting the NF-κB signaling pathway, thereby lowering levels of inflammatory factors such as TNF-α and IL-6. Regarding myocardial ischemia-reperfusion injury (MIRI), salvianolic acid B bulk can reduce myocardial cell apoptosis and infarct size by upregulating SIRT3 expression, reducing mitochondrial reactive oxygen species (mtROS) accumulation, and inhibiting NLRP3 inflammasome activation.

Furthermore, this compound also possesses antiplatelet aggregation and thrombolytic effects. Its mechanism of inhibiting platelet aggregation is similar to that of aspirin, and it can dissolve existing thrombi. In terms of vascular protection, salvianolic acid B powder can improve endothelial dysfunction, regulate vascular tone, and promote angiogenesis in ischemic areas. 

salvianolic acid b for eye

Salvianolic acid B exhibits multifaceted protective effects in ophthalmology. In diabetic retinopathy, it can inhibit oxidative stress and inflammation by activating the Nrf2/HO-1 signaling pathway, thus reducing retinal damage. Simultaneously, it can inhibit the RIP1/RIP3/MLKL signaling pathway, reducing glucose-induced necrotizing apoptosis of retinal pigment epithelial cells. For age-related cataracts, salvianolic acid B can inhibit apoptosis of lens epithelial cells, showing potential for prevention and treatment. In retinal pigment epithelial cells, salvianolic acid B powder can counteract oxidative stress-induced cell damage by upregulating glutreonin 1 expression, providing a new approach for the treatment of age-related macular degeneration.

salvia miltiorrhiza root extract for skin

Salvia miltiorrhiza extract offers numerous health benefits for the skin. In terms of whitening and fading dark spots, its salvianolic acid components effectively inhibit tyrosinase activity, thus improving dullness and pigmentation. Regarding anti-aging, salvia miltiorrhiza extract possesses potent antioxidant capabilities, scavenging free radicals, inhibiting elastase activity to prevent skin sagging, and promoting the synthesis of type I procollagen, reducing wrinkles and enhancing skin elasticity. In terms of anti-inflammatory and soothing effects, it inhibits the production of inflammatory factors such as TNF-α and IL-6, reducing skin redness and irritation, and has a repairing effect on sensitive and acne-prone skin.

salvianolic acid b supplement

Salvianolic acid B, a representative active ingredient in Danshen (Salvia miltiorrhiza), is primarily used in health supplements for cardiovascular health, antioxidant purposes, and healthy aging. Common product forms on the market include capsules, tablets, plant extract complexes, functional beverages, and instant powders. Salvianolic acid B is frequently combined with ingredients such as coenzyme Q10, fish oil,

nattokinase,

grape seed extract, and

resveratrol to develop products for heart health and circulatory support; it is also often combined with vitamin C, vitamin E, and other natural antioxidants for antioxidant and healthy aging formulations.

salvia miltiorrhiza extract skincare product

In serums and essences, the extract is often added in high concentrations to serums or ampoules to target pigmentation, dullness, and early signs of aging, providing whitening and anti-wrinkle effects. Face masks are another major application, offering immediate brightening and soothing effects. Repairing lotions and creams combine miltiorrhiza root extract with moisturizers and oils, making them suitable for daily care of sensitive and acne-prone skin. Furthermore, adding the extract to toners and essences creates functional waters with antioxidant and soothing properties; its ability to improve microcirculation is used in eye creams to help reduce dark circles; and some cleansing mud masks and sprays also contain danshen extract to enhance their antibacterial and soothing effects.

Under normal use conditions, tanshinone extract exhibits high safety. Regarding skin safety, a 1% concentration of salvia miltiorrhiza extract showed no irritation or sensitization in skin irritation, eye irritation, and skin sensitization tests. In cosmetic applications, tanshinone extract is listed in the Catalogue of Used Cosmetic Ingredients (2021 Edition), with the highest historical usage for leave-on products at 2.5% and for rinse-off products at 4%. However, it should be noted that some studies suggest that long-term administration of high doses may cause reversible changes in liver function indicators; therefore, clinical application and product addition should be controlled within safe dosage ranges.

Choosing our best salvia miltiorrhiza extract powder stems from our rigorous quality control and end-to-end traceability. Firstly, we strictly select Danshen herbs from authentic medicinal herb-producing areas, ensuring that the content of tanshinone B and tanshinone active ingredients exceeds pharmacopoeia standards. All batches pass HPLC chromatographic comparison and content uniformity verification, and third-party testing reports are provided to ensure the stability and reliability of every gram of powder. Furthermore, we offer flexible supply capabilities from R&D-level samples to ton-scale commercial batches, supporting customized particle size and sterilization processes, and are equipped with ISO 22000 and cGMP dual-system production workshops. Choosing us means choosing a safe, effective, transparent, and traceable Danshen extract solution. Buy salvia miltiorrhiza root extract powder, contact us at

info@kintaibio.com.

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