L-5-MTHF-Ca L Methylfolate Calcium Powder Manufacturer/ Factory/ Supplier
Methyltetrahydrofolate is the full chemical name for methyltetrahydrofolic acid, commonly abbreviated as 5-MTHF in the industry. It falls into the category of active folate. This substance has two stereoisomers: L-form and D-form, among which only the L-form possesses physiological activity.
The commonly referred to Methylfolate and L-Methylfolate specifically mean the bioavailable levorotatory isomer that can be utilized by the human body. Its official standard name is L-5-MTHF, and its chemical alias is Levomefolic acid. (L Methylfolate Vs 5 MTHF)
Healthkintai®'s core product is L-5-MTHF-Ca L Methylfolate Calcium Powder, manufactured with L-5-MTHF active monomer as the raw material. Compared with the free acid form, its calcium salt features superior stability, longer shelf life and broader applicability. The product achieves a purity of 98%–99%, contains solely the 6S active isomer with no ineffective D-form impurities. Complying with USP and EP pharmacopoeia standards, it is a preferred active folate raw material for high-end health supplement manufacturers, pharmaceutical enterprises and medical food producers worldwide.
Contact us at health@kintaibio.com for the free sample now.
Calcium L Methylfolate Vs 5 MTHF
5-MTHF free acid and L-methylfolate calcium share the same core active ingredient, namely the physiologically active 6S levorotatory isomer, so they deliver identical efficacy. The key difference lies in their chemical forms. As the original free acid, 5-MTHF has inferior stability, water solubility and formulation compatibility, along with stringent storage requirements, and is mainly used for laboratory tests and custom formulations. In contrast, L-methylfolate calcium, a calcium salt derivative, boasts superior physicochemical properties and broader applicability, making it the mainstream commercial raw material for dietary supplements, pharmaceuticals and related products.
| Comparison Items | 5-MTHF (Free Acid) | Calcium L-Methylfolate (L-5-MTHF-Ca) |
| Chemical Form | Free Acid | Calcium Salt |
| Active Ingredient | L-5-MTHF (6S active isomer) | L-5-MTHF (6S active isomer, free of D-form impurities) |
| Physiological Activity | Bioactive for human body | Identical activity; takes effect after dissociation in vivo |
| Stability | Poor, prone to oxidation and decomposition by moisture | Excellent, anti-oxidative, heat-resistant and non-hygroscopic |
| Shelf Life | Short, requiring strict storage conditions | Long, suitable for long-term storage under normal conditions |
| Solubility | Moderate water solubility | Better water solubility |
| Formulation Compatibility | Reacts easily with acidic materials, limited application | Compatible with acid and alkaline systems, widely applicable |
| Main Applications | Laboratory use & customized high-end formulations | Dietary supplements, pharmaceuticals and medical foods (mainstream commercial raw material) |
| Compliance Standard | Compliant with USP/EP | Strictly in line with USP/EP pharmacopoeia standards |
Regulatory Status of L-5-MTHF-Ca L Methylfolate Calcium Powder
JECFA (Joint FAO/WHO Expert Committee on Food Additives)
The committee completed a comprehensive safety assessment of L-5-methylfolate calcium in 2005. It concluded that the ingredient poses no food safety risks, and approved its use in forms such as crystals and microcapsules for dietary supplements, special dietary foods and general food fortification.
US FDA
L-5-methylfolate calcium has obtained GRAS (Generally Recognized As Safe) status in the United States and is permitted for direct addition into dietary supplements. It was registered as a New Dietary Ingredient in 2001. Included in the USP Dietary Supplement Compendium, this active folate can be widely used in dietary supplements, functional foods and prescription pharmaceutical products.
EFSA (European Food Safety Authority)
EFSA confirms the safety of this ingredient and sets a maximum daily intake limit of 1 mg for adults. It is approved for use in food supplements, fortified foods, infant formula and foods for special medical purposes.
What Are the Benefits of L-5-MTHF?
L-Methylfolate for Pregnancy
L-Methylfolate for MTHFR
L-methylfolate is the naturally active form of folate that can directly participate in the systemic methylation cycle without catalytic activation by the MTHFR enzyme. For women trying to conceive or during pregnancy who carry MTHFR gene mutations and suffer from insufficient enzyme activity, rendering ordinary synthetic folate difficult to convert and utilize, L-methylfolate bypasses metabolic bottlenecks to rapidly reduce harmful homocysteine in the body. It steadily maintains normal folate metabolism in the maternal body, prevents metabolic disorders caused by impaired folate activation, and can cross the placenta to deliver nutrients directly to the fetus, addressing the core issue of inadequate folate absorption and utilization in individuals with genetic defects.
L Methylfolate for Fertility
Adequate active L-methylfolate alleviates damage to germ cells induced by elevated homocysteine, optimizes the ovarian environment, improves oocyte quality, enhances endometrial receptivity, facilitates smooth embryo implantation and effectively boosts the chance of natural conception. After successful pregnancy, the methyl groups it supplies support fetal DNA synthesis and the normal differentiation of the neural tube, cardiovascular system and various organs. It prevents neural tube defects such as spina bifida and anencephaly during the critical first trimester, and reduces adverse pregnancy outcomes triggered by high homocysteine including recurrent miscarriage, fetal arrest, gestational hypertension and insufficient placental blood supply, comprehensively safeguarding maternal well-being throughout pregnancy and normal fetal development.
L Methylfolate for Kids
L Methylfolate for ADHD
As the biologically active form of folate, L-methylfolate provides essential methyl donors for DNA synthesis and myelin development of nerve cells in children's hippocampus and prefrontal cortex. Children with underactive MTHFR gene variants cannot properly activate ordinary folic acid, leading to accumulation of homocysteine in the body, which impairs cerebral nerve transmission and blocks brain signal transduction, manifesting as classic ADHD symptoms including poor concentration, impulsive behaviors and restlessness. Supplementation with L-methylfolate bypasses metabolic defects to rapidly reduce homocysteine levels, repair damaged neural pathways and improve the efficiency of brain signal transmission, fundamentally alleviating ADHD manifestations such as distractibility, hyperactivity and poor self-control in children.
L Methylfolate for Anxiety
The synthesis of mood-regulating neurotransmitters such as dopamine and serotonin in the brain is highly dependent on the supply of methyl groups. Impaired folate metabolism directly inhibits the production of these two neurotransmitters, making children emotionally sensitive, irritable and prone to anxiety and restlessness. L-methylfolate continuously delivers abundant methyl precursors to sustain steady secretion of serotonin and dopamine, balance the brain's emotional regulation system, and relieve negative moods including impatience, irritability and frequent crying in children. In addition, this active form of folate boosts hematopoiesis and immunity, and simultaneously supports the long-term healthy development of children's intelligence and bones.
L Methylfolate for Depression
Most individuals with depression commonly exhibit impaired metabolism or genetic mutations of the MTHFR gene, which directly hinder the synthesis and release of three core mood-related neurotransmitters: serotonin, dopamine, and norepinephrine. Insufficient secretion of these neurotransmitters triggers an imbalance in the emotional regulatory system, manifesting as hallmark depressive symptoms including persistent low mood, anhedonia, inner emptiness, pessimism and anxiety, and slowed thinking. Some patients also experience concurrent complications such as sleep disturbances, mental exhaustion, and irritability.
Supplementing L-methylfolate delivers dual benefits: on one hand, it efficiently breaks down and eliminates excess homocysteine in the body to mitigate neurotoxicity and repair damaged neural signal transmission pathways; on the other hand, it facilitates the production of mood neurotransmitters, steadily elevating cerebral concentrations of serotonin, dopamine and other transmitters to balance central emotional regulation in the brain. It ameliorates depressive predispositions at the root metabolic level, alleviating mild to moderate depression, low mood and anxiety. In addition, it augments the efficacy of antidepressant medications, improves sleep quality and mental vitality in depressed populations, and reduces frequent emotional swings.
L-5-MTHF-Ca L Methylfolate Calcium Powder Uses
In Pharmaceuticals
L-methylfolate calcium is a pharmacopoeia-grade active folate API directly applied in the production of prescription drugs, medical foods and special therapeutic preparations. Clinical end products include prescription-grade L-methylfolate tablets (7.5mg / 15mg specifications), medical foods for adjuvant treatment of depression, special formulations for hyperhomocysteinemia, and targeted folate-correcting medicines for patients with MTHFR gene defects. It can also be combined with methylcobalamin and pyridoxal 5'-phosphate to manufacture compound cardiovascular and cerebrovascular drugs. Additionally, it serves as a core ingredient in injectable preparations and oral hematinic agents for treating folate-deficient megaloblastic anemia.
In Dietary Supplements
L-methylfolate calcium boasts the advantage of high bioavailability. Its core end products fall into four major series: premium pre-pregnancy and prenatal active folate tablets, as well as compound prenatal multivitamin softgels; methylation-supporting compound B-vitamin powders and capsules; cardiovascular care tablets for middle-aged and elderly consumers (formulated with methylcobalamin, Coenzyme Q10 and fish oil); oral liquids for mood regulation and cognitive support. It is also available in convenient lightweight formulations including instant solid beverages, chewable tablets and probiotic complex nutrient powders. Microencapsulated raw material addresses the issue of photo-oxidation of folate.
In Infant Complementary Foods & Children's Nutritional Products
With food safety approvals granted by the EU and domestic authorities, L-methylfolate calcium can be safely applied to nutritional products for infants and children aged 0–12 years. End products cover stage 1 / stage 2 infant formula powder, baby cereal rice flour, children's multivitamin chewable tablets, liquid vitamin drops for kids, growth milk tablets, and brain-boosting solid beverages for school-age children. The low-dose raw material complies with tolerance standards for infants, addresses children's inherent weak capacity to convert folate, and reduces risks of poor concentration and developmental delay in adolescents.
Where to Buy the Best L-5-MTHF-Ca L Methylfolate Calcium Powder?
Healthkintai® is deeply engaged in the field of pharmaceutical intermediates and dietary supplement raw materials, integrating independent R&D, standardized production and global sales to provide one-stop supply of high-quality active folate raw material – L-5-MTHF-Ca L Methylfolate Calcium Powder.
Adopting a highly selective synthesis process, the product features a pure levorotatory active configuration with D-type inactive impurities thoroughly removed. Its purity is stably maintained between 98% and 99%. As a calcium salt, it boasts superior physicochemical stability and is compatible with the formulation development of various preparations.
The entire production chain is strictly controlled in accordance with GMP standards, supported by a full set of complete qualification certifications. Complete test certificates are issued for every batch, featuring minimal batch-to-batch differences and controllable content fluctuations. It is widely applied in pharmaceutical intermediates, prenatal and postnatal nutrition products, multi-B complex dietary supplements and other applications.
Backed by self-developed technologies and large-scale production lines, we deliver consistent bulk supply alongside customized services, making us a long-trusted raw material partner for nutraceutical and pharmaceutical enterprises. Please feel free to contact us at
health@kintaibio.com for inquiries and purchasing.
FAQ
Q: Why is l methylfolate so expensive?
A: Methylfolate (6S-5-methyltetrahydrofolate) is priced far higher than ordinary synthetic folic acid due to multiple high-cost barriers at its core: it is the biologically active natural form of folate, whose production involves multiple sophisticated processes including reduction, methylation and chiral resolution. Only the 6S levorotatory isomer possesses biological activity, resulting in massive raw material loss during resolution. Multi-layer chromatography and recrystallization are required to eliminate heavy metals and process impurities, driving up purification costs substantially. Moreover, this substance is highly susceptible to oxidative degradation when exposed to light, heat and oxygen, so the entire procedures of production, filling and storage must be carried out under light-proof, oxygen-isolated and temperature-controlled conditions, which greatly raises costs of auxiliary materials and packaging.
Q: Is l-5-methyltetrahydrofolate the same as methylfolate?
A: L-5-methyltetrahydrofolate and the methylfolate available on the market are essentially the same active folate, commonly shortened to methylfolate in the industry. Its full standard chemical name is 6S-L-5-methyltetrahydrofolate, where the L configuration corresponds to the chiral 6S configuration. It is the biologically active isomer that can be directly absorbed and utilized by the human body without secondary metabolic conversion in the liver. In daily communication among merchants and raw material manufacturers, methylfolate specifically refers to this biologically active L-type monomer, which differs from the physiologically inactive D-type racemate and ordinary inactive synthetic folic acid. The two terms are merely variations between a shortened name and the full nomenclature, and they refer to the exact same active ingredient.
Hot Tags: l-5-mthf-ca l methylfolate calcium powder, China l-5-mthf-ca l methylfolate calcium powder manufacturers, suppliers, factory, Coenzyme Q10 Powder, green tea powder supplement, organic astragalus root extract, l theanine powder dosage, Sulforaphane Powder, vitamin c lysine powder
