Alpha Mangostin Solubility and Uses

As the core active component of mangosteen peel extract, α-mangostin is inherently lipophilic, a natural property that creates notable barriers to its development and application in water-based formulations—severely limiting its compatibility and efficacy in mainstream dosage forms such as oral liquids, water-soluble beverages, and aqueous cosmetics.

With over a decade of deep expertise in the R&D and production of plant extracts, Healthkintai^® boasts a professional R&D team and sophisticated technical processes. Targeting this key industry pain point, we offer customized solubility modification solutions. If you want to know more about our mangosteen peel extract, please contact us at health@kintaibio.com.

10% and 98% Alpha Mangostin powder

Alpha Mangostin Solubility

The solubility characteristics of α-mangostin are closely related to its molecular structure. With the molecular formula of C₂₄H₂₆O₆, it contains multiple hydrophobic isopentenyl groups and aromatic rings, while hydrophilic groups account for a small proportion, resulting in prominent lipophilicity and extremely slight solubility in water with a solubility of less than 0.1 mg/mL. Poor water solubility has become a major limiting factor for its application and development.

How Does HealthkintaiR Deal with Alpha Mangostin’s Solubility?

For our α-mangostin derived from mangosteen peel extract, we integrate solubility regulation throughout the entire extraction process based on the molecular structural principle of its lipophilic and hydrophobic properties.

• First, we adopt directional extraction technology with medium- and low-polarity solvents to match the lipophilic characteristics of α-mangostin, achieving efficient dissolution and enrichment of the target component.
• Then, we maintain its stable solubility in the alcohol phase through solvent phase transformation and gradient purification processes.
• Furthermore, in accordance with application requirements, we can realize the customized conversion of lipophilic raw α-mangostin into water-soluble preparations by virtue of core technologies such as cyclodextrin inclusion and surfactant solubilization.

Reference: https://www.mdpi.com/2073-4360/13/17/2890

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Alpha Mangostin Uses

Based on the solubility differences between the naturally lipophilic α-mangostin and its modified water-soluble preparations, the applications of mangosteen peel extract are divided into two major categories: lipophilic system applications and water-soluble system applications. Each category is adapted to different industrial scenarios, giving full play to the ingredient’s efficacy and formula compatibility. The specific classifications and application details are as follows.

Lipophilic System Applications

Leveraging the inherent lipophilic properties of α-mangostin, it can be directly incorporated into lipophilic composite formulations without additional modification, featuring stable ingredient dissolution and complete retention of efficacy. It is core-adapted to industrial scenarios compatible with lipophilic raw materials.

In the dietary supplements field

In the development of dietary supplements, lipophilic α-mangostin can be directly incorporated into vegetable oil bases and is highly compatible with dosage forms such as softgel capsules and vegetable capsules. The oil carrier not only ensures the stable dissolution of the active ingredient but also mimics the human body’s lipid absorption environment, facilitating the efficient intestinal absorption of α-mangostin and maximizing its core physiological effects, including antioxidant and anti-inflammatory activities.

In the cosmetics field

α-Mangostin exhibits an excellent and highly compatible match with mainstream lipophilic skincare formulations such as facial serums, creams, lip balms, and cleansing oils. Being lipophilic, it blends seamlessly with lipophilic bases in skincare products and can rapidly penetrate into the basal layer of the skin, avoiding issues like low transdermal absorption efficiency and poor efficacy performance caused by poor water solubility. In addition, α-mangostin has good compatibility when combined with oil-based skincare ingredients and can work synergistically with lipophilic skincare actives including squalane, vitamin E and plant essential oils.

Water-Soluble System Applications

Addressing the core requirements of aqueous formulation systems, lipophilic α-mangostin is converted into water-soluble powder/aqueous solution via cyclodextrin inclusion. It can be directly dissolved in water, low-alcohol phases, and water-soluble composite formulations and is primarily adapted to mainstream application scenarios based on an aqueous matrix.

In the cosmetics field

Water-soluble α-mangostin can be directly dissolved in aqueous bases, breaking through the limitation that the traditional lipophilic raw form is only suitable for oil-based formulations and enabling its core skincare benefits, such as antioxidant, anti-inflammatory, soothing, and moisturizing repair, to be fully exerted in various aqueous skincare products. In addition, water-soluble α-mangostin has excellent compatibility with mainstream water-based skincare actives, including hyaluronic acid, niacinamide, vitamin C, and water-soluble plant extracts.

In the beverages field

Water-soluble α-mangostin can be directly dissolved in aqueous bases, achieving stable dissolution and uniform dispersion under common beverage formulation conditions such as normal temperature and acidity, with no precipitation, delamination, or crystallization. It is suitable for the development and innovation of various beverage categories, including tea drinks, fruit and vegetable drinks, and herbal instant drinks.

Where to Buy Alpha Mangostin?

α-Mangostin is the  key active component of mangosteen rind extract. With over 10 years of experience in the R&D of plant extracts, Healthkintai^® boasts extensive expertise in both production and international trade. Email at health@kintaibio.com, and let us know your requirements.

• We fully support one-stop ODM & OEM customization services throughout the entire process.
• We have built a highly professional R&D team whose core members all hold master’s degrees or above. Equipped with a standardized professional laboratory and high-precision experimental and testing instruments, we provide solid technical support for the entire R&D and production processes of α-mangostin and other plant extracts.

• ·We hold a complete set of foreign trade import and export qualifications and a full range of product certification certificates, all of which have been officially examined, approved, and filed in a standardized manner, and fully comply with the import and export trade norms and customs supervision requirements of regions worldwide.