Ursolic acid powder

KINTAI, as a leader in the field of herbal extracts in China, is committed to providing customers with excellent ursolic acid products. The ursolic acid powder produced by our factory is derived from high-quality rosemary extract. With strict cGMP, ISO and HACCP international certification systems, we ensure that each batch of products meets the industry's top standards. 90% ursolic acid is our best-selling product. We can customize the production of ursolic acid with a purity of up to 98% according to customer needs.

Healthkintai^® stands at the forefront of ursolic acid powder production, leveraging state - of - the - art extraction and purification technologies. Sourced from carefully selected natural plant materials, our ursolic acid powder undergoes a meticulous manufacturing process in our GMP - certified facilities. Through advanced extraction techniques, we ensure that the final product maintains a high purity level, typically exceeding 98%. This consistent purity guarantees the powder’s stability and bioactivity, ensuring reliable performance across different applications.

The recommended dosage of ursolic acid powder can vary significantly based on its intended use, the individual's health status, and the form of the product in which it is consumed.​

Dietary Supplements​

For those using ursolic acid powder in dietary supplements to support general health, such as enhancing antioxidant capacity or promoting immune function, a common starting dosage ranges from 50 - 150 milligrams per day. This moderate intake allows the body to gradually adapt to the compound while providing potential health benefits. However, it's crucial to note that long - term use at higher doses without medical supervision may carry risks. Some studies suggest that for more targeted effects, like aiding in weight management or improving metabolic health, doses up to 300 milligrams per day might be considered, but this should be done under the guidance of a healthcare professional.​

Pharmaceutical Applications​

In a pharmaceutical context, where ursolic acid powder is used for specific therapeutic purposes, dosages are often determined by the nature and severity of the condition being treated. For example, in research related to certain inflammatory diseases or cancer treatment, clinical trials may employ doses starting from 500 milligrams up to several grams per day. These high - dose applications are strictly controlled within the framework of medical studies and should never be self - administered without proper medical authorization due to potential side effects and interactions with other medications.​

Cosmetic Use​

When it comes to skincare and cosmetic products containing ursolic acid powder, the concentration in the formulation is typically much lower compared to internal use. In creams, serums, or lotions, concentrations usually fall within the range of 0.1% - 2%. This percentage translates to a much smaller amount of ursolic acid being applied topically per use, as the product is spread over the skin surface. For instance, if using a cream with a 1% ursolic acid concentration, applying a pea - sized amount (about 0.5 grams) would mean applying 5 milligrams of ursolic acid. This lower dosage is sufficient for skin - nourishing effects like promoting collagen production and protecting against environmental damage without causing irritation or adverse reactions.​

1. Ursolic Acid (UA) Overview

· Definition & Properties: Ursolic acid (CAS: 77-52-1) is a pentacyclic triterpenoid carboxylic compound (C30H48O3), naturally occurring in plants like rosemary stems/leaves. It exists in free acid form or as glycones for triterpenoid saponins, with oleanolic acid (OA) as its isomer.

· Applications: Widely used in pharmaceuticals, cosmetics, and research for its anti-inflammatory, antioxidant, and antidiabetic properties.

2. Pharmacological & Functional Benefits

· Anti-Cancer Effects: Inhibits hepatocellular carcinoma (HepG2) growth via AMPKα-mediated DNA methyltransferase reduction.

· Metabolic Health: Improves insulin sensitivity and glucose metabolism in diabetes models.

· Cosmetic Uses: Enhances skin health by reducing oxidative stress and melanin production; high-purity UA (≥98%) is preferred for formulations.

3. Industrial & Commercial Highlights

· Product Specifications: Available in purities ranging from 20% to 98%, with stable storage conditions (-20°C for 3 years).

· Awards & Innovations: Related triterpenoid research has been recognized in industry awards (e.g., KTcos® S-grade boswellic acid winning the "China Good Ingredient Award").

· Global Market Expansion: Companies like Kintor Pharmaceutical are expanding into international markets (e.g., Japan) with bioactive ingredients.

4. Related Compounds & Market Trends

· Ursodeoxycholic Acid (UDCA): A derivative used to dissolve cholesterol gallstones and treat liver diseases (e.g., primary biliary cholangitis).

· Consumer Trends: Natural metabolites like Urolithin A (similar bioactive profile) are gaining traction in supplements, highlighting demand for UA-related products.

For specific product inquiries (e.g., KINTAI’s UA powder), refer to manufacturers’ catalogs or clinical studies.

1. Anti-inflammatory and Antioxidant Effects

Ursolic acid effectively inhibits the production of pro-inflammatory cytokines (such as TNF-α and IL-6), significantly reducing inflammatory responses. It is also a powerful antioxidant, neutralizing free radicals and alleviating cellular damage caused by oxidative stress. This underlies its protective effects on the liver, nervous system, and cardiovascular system.

2. Anti-cancer and Tumor Inhibition

Numerous studies have demonstrated that ursolic acid possesses potential anti-cancer activity. It can inhibit tumor cell proliferation, induce apoptosis, and inhibit tumor angiogenesis through multiple pathways, thereby preventing cancer cell growth and metastasis. It has demonstrated inhibitory effects on various cancer cell lines, including liver cancer, breast cancer, and colon cancer.

3. Liver Protection

Ursolic acid exhibits significant protective effects against chemical or alcoholic liver damage. It enhances the antioxidant capacity of liver cells, inhibits liver inflammation and fibrosis, promotes liver cell regeneration, and helps maintain liver health.

4. Anti-muscle atrophy and Muscle Growth

This is a highly noteworthy benefit. Ursolic acid activates signaling pathways that promote muscle growth (such as IGF-1) while inhibiting gene expression that leads to muscle breakdown. Therefore, it is considered to have great potential in preventing muscle atrophy caused by age or disease and increasing muscle mass and strength.

1. Pharmaceuticals and Health Products

Research has shown that ursolic acid can significantly reduce liver cell damage and fibrosis, making it a key ingredient in many liver-protecting health products and medications. It has shown promising results in improving insulin resistance and lowering blood lipids, and can be used to prevent diabetes and cardiovascular disease.

2. Cosmetics and Personal Care

Its potent antioxidant capacity effectively combats photoaging and oxidative stress, reduces wrinkles, and improves skin elasticity. For acne-prone skin, it can reduce inflammation and redness; for sensitive skin, it can calm and repair the skin barrier. By inhibiting key enzymes involved in melanin production, it helps brighten skin tone and reduce dark spots.

3. Functional Foods and Beverages

Its unique muscle-building and fat-reducing potential has made it a new favorite in sports supplements, helping athletes and fitness enthusiasts reduce muscle breakdown and increase lean body mass. As a natural antioxidant, it is added to beverages, candies, and yogurt to enhance their health properties.

1.Q:What does ursolic acid do for the body?

   A:Interestingly, ursolic acid increased energy expenditure, leading to reduced obesity, improved glucose tolerance, and decreased hepatic steatosis. 

2.Q:Can ursolic acid help with weight loss?

   A: Ursolic acid has been shown to be useful for weight loss, but there is a lack of sufficient clinical data to support this, and continued research is needed in terms of its safety and efficacy.

3.Q:What is another name for ursolic acid?

   A:Ursolic acid (sometimes referred to as urson, prunol, malol, or 3β-hydroxyurs-12-en-28-oic acid), is a pentacyclic triterpenoid identified in the epicuticular waxes of apples as early as 1920 and widely found in the peels of fruits, as well as in herbs and spices like rosemary and thyme.