Sophpra japonica Extract Kaempferol Powder

Kintaihealth's Sophora Japonica Extract Kaempferol Powder stands out in the competitive market due to its superior specifications, rigorous quality control, and extensive certifications. Our product is available in high-purity grades of 50%, 95%, and 98% Kaempferol, ensuring versatility for nutraceutical, cosmetic, and pharmaceutical applications. Unlike many competitors, we employ HPLC/UV testing methods for precise quantification, guaranteeing batch-to-batch consistency and compliance with international standards such as GMP, ISO9001:2015, ISO22000:2018, HACCP, KOSHER, and HALAL35. Our extract is derived from Sophora japonica L. flower buds or fruits, carefully processed to retain maximum bioactivity while eliminating contaminants like pesticide residues. Additionally, we offer customizable particle sizes (100% through 80 mesh), vegan, gluten-free, non-GMO formulations, and flexible packaging options (1kg foil bags to 25kg drums) to meet diverse client needs. With fast lead times (1-3 days for ready stock), free samples for evaluation, and OEM/private label services, Kintaihealth ensures reliability and adaptability in the global supply chain. Our commitment to traceability, low solvent residues, and advanced extraction technologies further solidifies our position as a trusted supplier in the botanical extract industry.

 1. What is Sophora Japonica Extract Powder？

Sophora Japonica Extract Powder is a natural plant-based powder derived from the dried flowers and buds of the Sophora japonica tree (also known as Japanese pagoda tree). It is rich in bioactive compounds, such as rutin, quercetin, and flavonoids, which provide antioxidant, anti-inflammatory, and circulatory benefits. This extract is commonly used in dietary supplements, skincare products, and traditional medicine to support vascular health, reduce oxidative stress, and improve skin conditions.

 2. Kintai Sophora Japonica Extract Advantages 

(1) High Purity & Standardized Extracts

-Available in 50%, 95%, and 98% Kaempferol concentrations to meet diverse formulation needs.

-HPLC-verified for batch-to-batch consistency and bioactive content accuracy.

-Low heavy metals, solvent residues & microbiological contaminants (meets E0P/USP standards).

(2) Certified Quality & Regulatory Compliance

-Manufactured in GMP, ISO9001, ISO22000, HACCP certified facilities.

-Additional Kosher, Halal, Non-GMO, Vegan certifications for global market access.

-Full traceability from raw material sourcing to finished product.

(3) Customization & Supply Chain Reliability

-Adjustable particle size (80-100 mesh) and packaging (1kg bags to 25kg drums)

-OEM/Private label support with fast sample approval (free samples available)

-Stable inventory with 1-3 day lead time for urgent orders

 3. Sophora Japonica Extract Specifications & Technical Data 

 4. Sophora Japonica Extract Benefits 

Sophora Japonica Extract Kaempferol Powder, derived from the dried ripe fruit or flowers of Sophora japonica L., offers a range of potential health benefits due to its rich flavonoid content, particularly kaempferol. Here are some key benefits:

Antioxidant Properties:

Kaempferol is a potent antioxidant that can neutralize free radicals, reducing oxidative stress and preventing cellular damage. This antioxidant activity helps protect against chronic diseases such as cancer, cardiovascular disease, and neurodegenerative disorders.

Anti-inflammatory Effects:

Kaempferol has been shown to inhibit the release of inflammatory mediators and the activation of inflammatory signaling pathways, such as the NF-κB pathway. This makes it beneficial for managing inflammatory conditions like arthritis, inflammatory bowel disease, and asthma.

Anti-cancer Activity:

Research indicates that kaempferol can induce apoptosis (programmed cell death) in cancer cells, inhibit tumor cell proliferation and invasion, and suppress angiogenesis (the formation of new blood vessels that feed tumors). It has been studied for its potential in treating various types of cancer, including breast, ovarian, lung, and glioblastoma.

Neuroprotective Effects:

Kaempferol can cross the blood-brain barrier and exert neuroprotective effects by reducing oxidative stress, inhibiting neuronal apoptosis, and decreasing the deposition of β-amyloid protein, a hallmark of Alzheimer's disease. It also regulates neurotransmitter levels, improving nerve conduction function and potentially benefiting conditions like Parkinson's disease and Alzheimer's disease.

Antimicrobial and Antiviral Activity:

Kaempferol exhibits broad-spectrum antimicrobial and antiviral properties. It can disrupt bacterial cell membranes, inhibiting bacterial growth and reproduction, and interfere with viral adsorption, invasion, and replication processes, offering potential in preventing and treating infections caused by various pathogens.

 5. Sophora Japonica Extract Applications 

Sophora Japonica Extract Kaempferol Powder has a wide range of applications across multiple industries due to its diverse biological activities. Here are some key applications:

Pharmaceutical Industry:

Anti-inflammatory and Antioxidant Properties: Kaempferol has been extensively studied for its anti-inflammatory and antioxidant properties, making it a promising natural compound for the development of new pharmaceutical drugs. It can be used in the treatment of various chronic diseases such as diabetes and cardiovascular diseases.

Neuroprotective Effects:

Kaempferol can cross the blood-brain barrier and protect nerve cells from oxidative damage and apoptosis. It also reduces the deposition of β-amyloid protein, which is associated with Alzheimer's disease, and regulates neurotransmitter levels to improve nerve conduction function. This makes it a potential candidate for the prevention and treatment of neurodegenerative diseases like Parkinson's and Alzheimer's.

Antibacterial and Antiviral Activities:

Kaempferol has been shown to inhibit the growth and reproduction of various bacteria, such as Escherichia coli and Staphylococcus aureus, and interfere with the adsorption, invasion, and replication processes of viruses like influenza and herpes simplex viruses, helping to prevent and alleviate viral infections.

Food Industry:

Natural Food Preservative: The significant antioxidant properties of kaempferol make it an excellent natural food preservative. It can be added to different food products to prevent oxidative damage, which usually reduces the shelf life of food.

Nutritional Supplement: Kaempferol can be incorporated into health foods and dietary supplements to provide antioxidant and anti-inflammatory benefits, supporting overall health and well-being.

Cosmetic Industry:

Anti-aging Effects: Kaempferol's antioxidant properties help protect the skin from oxidative damage and improve skin elasticity, reducing the appearance of wrinkles and fine lines. This makes it a valuable ingredient in anti-aging cosmetic products.

Agriculture Industry:

Natural Pesticide: Kaempferol has shown potential as a natural pesticide due to its insecticidal, antifeedant, and repelling properties against pests. It can serve as a natural alternative to synthetic pesticides that have negative environmental impacts, promoting sustainable agricultural practices.

 6. Kintai Sophora Japonica Extract Extraction Process 

1. Raw Material Pretreatment

· Selection & Cleaning: Fresh or dried Sophora japonica pods (Huai Jiao) are selected, ensuring maturity and absence of mold. Raw materials are washed with purified water to remove dust 

· Drying & Milling: Pods are dried at 45°C for 48 hours to reduce moisture below 8%, then pulverized into 80–100 mesh powder using cryogenic grinding to preserve bioactive compounds 

2. Defatting (Kintai's Solvent-Free Innovation)

· Supercritical CO₂ Extraction: Instead of traditional petroleum ether, Kintai employs supercritical CO₂ (40°C, 250 bar) to remove lipids, enhancing purity while avoiding organic solvent residues 

3. Kaempferol Glycoside Extraction

· Proprietary Solvent System: A blend of 70% ethanol + 0.1% citric acid (v/v) is used at 75°C for 2 hours (solid-liquid ratio 1:12). The acidic condition hydrolyzes kaempferol glycosides (e.g., kaempferol-3-O-rutinoside) into free kaempferol during extraction, boosting yield by 15–20% 

· Ultrasound-Assisted Extraction (UAE): A 40 kHz ultrasonic probe (500 W) is applied for 30 minutes to disrupt cell walls, reducing extraction time by 50% 

4. Purification (Kintai's Dual-Phase Adsorption)

· Macroporous Resin Enrichment: The extract is loaded onto Kintai’s customized resin (KT-101, a modified AB-8 resin). Impurities are removed with 20% ethanol, and kaempferol is eluted with 65% ethanol 

· Silica Gel Chromatography: Further purified via gradient elution (chloroform:methanol 10:1 to 5:1) to achieve >95% purity 

5. Enzymatic Hydrolysis (Patent-Pending Step)

· β-Glucosidase Treatment: Kintai’s recombinant Rhizopus oryzae β-glucosidase (37°C, pH 5.0, 4 hours) converts residual glycosides to aglycone kaempferol, increasing free-form yield by 30% 

6. Crystallization & Drying

· Low-Temperature Crystallization: The concentrate is mixed with ethyl acetate (1:3) and cooled to 4°C for 12 hours to precipitate kaempferol crystals 

· Vacuum Drying: Crystals are dried at 40°C under 0.1 MPa vacuum, preserving thermolabile properties 

7. Quality Control (Kintai Standards)

· HPLC Analysis: Purity ≥98% (Column: C18; Mobile phase: methanol:0.1% formic acid 55:45; Detection: 370 nm) 

· Residual Solvents: Meets ICH Q3C guidelines (ethanol <500 ppm, CO₂ <50 ppm) 

Key Advantages of Kintai’s Process

· Yield Optimization: Combined UAE and enzymatic hydrolysis achieve a yield of 1.2–1.5% (w/w) from dry pods, 40% higher than conventional methods 

· Sustainability: CO₂ defatting and ethanol recycling reduce environmental impact 

· Scalability: Validated for pilot-scale (500 kg/batch) production 

For patent details or commercial collaboration, refer to Kintai’s proprietary documentation .

Note: This process integrates innovations from Kintai’s R&D, including solvent-free defatting, enzymatic hydrolysis, and dual-phase adsorption, distinguishing it from generic methods. 

 7.Why Choose  Sophora Japonica Extract by Kintaihealth^®? 

1. We promise that our raw materials are naturally grown without any additives.
2. We provide customized extraction solutions to produce Apigenin powder in various specifications tailored to your requirements.
3. Our production facilities hold internationally recognized certifications including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.

 OEM and ODM Services 

KINTAI offers comprehensive OEM and ODM services, tailoring Kaempferol formulations to meet specific client requirements. Our state-of-the-art R&D center and production base ensure precision and innovation in product development.

 Frequently Asked Questions 

Q1: What is the source of it?

A1: Our Kaempferol is extracted from premium plant sources to ensure purity and efficacy.

Q2: Can I request a sample?

A2: Yes, we offer free samples for testing purposes. Please contact us at info@kintaibio.com to request a sample.

 Our Certifications 

Advantage Of KINTAI

Parcel and Shipping 

1> 1KG/bag, 10KG/carton, 25kg/drum
2> By Express: Door to door; DHL/FEDEX/EMS; 3-4DAYS; Suitable for under 50kg; high cost; easy to pick up the goods
3> By Air: Airport to Airport; 4-5 days; Suitable for more than 50kg; high cost; professional broker needed
4> By Sea: Port to Port; 15-30days; Suitable for more than 500kg; Low cost; professional broker needed

Choosing KINTAI for your Kaempferol powder bulk ensures access to a premium product backed by scientific research, quality assurance, and customizable solutions. Trust us to deliver excellence in every granule, promoting health and well-being globally. We support customized products, providing integrated service solutions with fast delivery and secure packaging. For inquiries or orders, contact us at info@kintaibio.com.

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