Macleaya Cordata extract total alkaloids60% powder

Macleaya cordata extract is derived from Macleaya cordata, composed of a mixture of beneficial compounds. Designated as 60% total alkaloids, it indicates that the active alkaloid components—key bioactive substances in Macleaya cordata—account for 60% of the content. These alkaloids are recognized for multiple biological functions, including antibacterial effects, growth promotion in animals, immunity enhancement, appetite regulation, and stress reduction.

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Macleaya cordata is extracted with ethanol, concentrated, and dissolved in acidified water. After separation, the aqueous phase is basified (e.g., withNH₄OH) to precipitate crude alkaloids, which are then centrifuged or filtered. The crude alkaloids are purified via silica gel chromatography,and sanguinarine-rich fractions are basified to precipitate pure sanguinarine, which is filtered and dried.

Macleaya cordata extract is a versatile natural product primarily valued for its high concentration of bioactive alkaloids like sanguinarine.

Its most significant application is in animal husbandry as a natural feed additive, where it promotes growth performance and gut health by modulating intestinal microbiota and reducing bacterial infections. Beyond agriculture, the extract serves important functions in veterinary medicine for treating digestive disorders, in organic farming as a plant-based pesticide, and in human consumer products.

Its potent anti-inflammatory and antimicrobial properties make it particularly effective in oral care products like toothpaste to combat plaque and gingivitis, as well as in specialized skincare formulations targeting acne and inflammation. 

Macleaya cordata extract (MCE) has gained widespread application in modern livestock farming due to its multifaceted pharmacological properties. Contemporary research confirms that MCE exhibits significant anti-inflammatory, antibacterial, and antitumor activities, positioning it as an important veterinary supplement for long-term use. Its primary benefits include enhancing intestinal health and optimizing growth performance in farm animals, making it a valuable natural alternative to conventional growth promoters in sustainable animal production systems.

Based on current research and application data, Macleaya cordata extract is generally considered safe when used appropriately within recommended guidelines. Its safety profile is strongly dependent on dosage and purity levels. The extract's primary active components, particularly sanguinarine, have demonstrated selective antimicrobial activity that favors its use in animal nutrition. In veterinary applications, standardized extracts with defined alkaloid content have shown no significant adverse effects on animal health or product safety when administered at approved concentrations. However, like any bioactive substance, excessive doses beyond established limits should be avoided.

（Reference：https://pmc.ncbi.nlm.nih.gov/articles/PMC9412730/）

（Reference：Animal Feed Science and Technology，Poultry Science）

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Q1:What does sanguinarine toxin cause?

A1:Sanguinarine exerts its toxic effects primarily through multiple mechanisms at the cellular level. It disrupts critical cellular functions by inhibiting the Na+/K+-ATPase enzyme, which is essential for maintaining membrane potential and ionic balance. Furthermore, it intercalates into DNA, interfering with replication and transcription processes, ultimately leading to cell cycle arrest and programmed cell death (apoptosis). The compound also induces oxidative stress by generating reactive oxygen species (ROS), causing additional damage to cellular components. 

Q2:Is sanguinarine used in skin care?

A2:Yes, sanguinarine is utilized in skincare, primarily for its dual antimicrobial and anti-inflammatory properties. Its most established application is in formulations targeting acne-prone skin, where it effectively inhibits Cutibacterium acnes, the primary bacterium associated with inflammatory acne lesions. By reducing bacterial proliferation and calming the underlying inflammation, it helps decrease the frequency and severity of breakouts. Its mechanism also involves modulating cellular signaling pathways. However, due to its potent bioactivity, its use is carefully regulated and optimized at low, safe concentrations to ensure efficacy without causing skin irritation.