Gynostemma Extract Gypenosides Powder

Gynostemma pentaphyllum extract, also known as Jiaogulan Extract, is derived from the dried whole whole gynostemma herb. Its marker active constituent is gypenosides, alongside gynostemma polysaccharides and flavonoids. Some gypenosides share similar chemical structures with ginsenosides. This natural botanical ingredient features antioxidant properties. It helps support immune health, relieve physical fatigue, and assists in maintaining healthy blood lipid and blood sugar levels. As a medicinal and edible raw material, Jiaogulan Extract is commonly used in dietary supplements, hard capsules, solid beverages, herbal teas and other functional foods. It can also serve as a raw material for herbal preparations and be incorporated into skincare products for antioxidant and skin-soothing benefits.

Healthkintai^® is a professional gynostemma extract supplier from China. We specialize in the R&D and production of botanical extracts and deliver a full range of product solutions, including ratio extracts and our flagship standardized extracts to meet custom formulation requirements for diverse clients. Our best-selling specifications of gynostemma extract are listed in the table below. Feel free to contact us at health@kintaibio.com for inquiries, quotations and sample requests.

Gynostemma pentaphyllum extract is permitted for use as a dietary supplement, functional food or traditional herbal medicine in many countries and regions worldwide, mainly including the Republic of Korea, Canada, the United States, Japan, Taiwan region of China, Thailand, Vietnam, Singapore, Malaysia, Australia, New Zealand, India, etc.

In the Republic of Korea, gynostemma pentaphyllum leaf extract obtained individual certification from the Ministry of Food and Drug Safety (MFDS) in 2013 and can be used as a raw material for functional health foods.

In Canada, Gynostemma pentaphyllum is included in the monograph of traditional Chinese medicinal ingredients issued by Health Canada and may be used as an ingredient in Natural Health Products (NHP).

In the United States, dietary supplement products containing Gynostemma pentaphyllum extract are widely available on the market.

In Japan, Gynostemma pentaphyllum is listed in the "List of Extracts (Raw Materials) Permitted for Food Use", and its extract can also be used as a cosmetic raw material.

The global Gynostemma pentaphyllum extract market is generally growing, but due to differences in statistical scope among institutions (such as finished extract versus gypenoside raw materials), market size estimates range from tens of millions to over US$100 million, while trend assessments are relatively consistent. Growth is mainly driven by global "adaptogen" and plant-based health consumption trends; because Gynostemma pentaphyllum contains saponins, it is often used in dietary supplements and food and beverage development for areas such as immunity, cardiovascular health, stress management, and metabolism.

According to some China market data, health supplements, pharmaceuticals, and food and beverages account for approximately 45%, 32%, and 23%, respectively; functional beverages and convenient formats such as instant powders and lozenges are growing rapidly. North America is regarded as a high-value growth market, while Asia-Pacific remains the main supply region.

Gynostemma Weight Loss

G pentaphyllum extract is rich in gypenosides and serves as a dietary ingredient to support weight management. Its mechanism of action is associated with activating the AMPK signaling pathway. It helps inhibit preadipocyte differentiation and regulate genes related to fat synthesis, reducing lipid droplet formation and lipid accumulation.

 

Meanwhile, it supports fatty acid oxidative metabolism, helps maintain healthy insulin sensitivity, and modulates serum triglyceride and cholesterol levels. Relevant studies show that gypenosides can mildly inhibit pancreatic lipase, regulate gut microbiota, and boost thermogenesis in brown adipose tissue, helping keep visceral and subcutaneous fat within a healthy range.

Jiaogulan Benefits for Men

Gynostemma pentaphyllum extract delivers multiple health benefits for men, including metabolic regulation, reproductive support and anti-fatigue effects.

 

Relevant clinical studies demonstrate that healthy men who supplemented with this ingredient for 4 consecutive weeks saw improved performance in a 20 km time trial, alongside marked improvements in leptin and blood glucose levels.

 

Basic research on reproductive health shows that Gynostemma pentaphyllum extract increases serum testosterone and mitigates testicular tissue damage in heat-stressed laboratory mice. Its active gypenosides inhibit the proliferation, migration and invasion of prostate cancer cells in cell studies, and provide antioxidant protection against chronic nonbacterial prostatitis in animal models.

 

Furthermore, gypenosides reduce post-exercise lactic acid buildup and boost anaerobic power output to help ease exercise-induced fatigue.

Jiaogulan Hair Loss

Gynostemma pentaphyllum extract contains gypenosides, which help activate the Wnt/β-catenin and AKT signaling pathways, support the proliferation of dermal papilla cells, raise levels of hair follicle-related growth factors including VEGF, IGF-1 and KGF, and modulate TGF-β1 to help delay premature follicle entry into the telogen phase and maintain an extended hair growth cycle.

 

This ingredient delivers antioxidant and soothing benefits, assisting in free radical scavenging, mitigating inflammatory irritation around hair follicles, reducing oxidative stress burden on follicles, and supporting improved scalp blood circulation to deliver nutrients to hair follicles. It may help boost hair density and strengthen hair shaft thickness, provide scalp and hair care benefits for stress-related hair loss, and assist melanin production to support improvement of premature hair graying. It is a natural botanical raw material for scalp and hair care applications.

Gypenosides Protect the Nervous System

Gynostemma leaf extract synergistically supports nervous system health through multiple mechanisms including antioxidant, anti-inflammatory, anti-apoptotic and autophagy-modulating effects. For antioxidant activity, this extract activates the Nrf2/ARE signaling pathway to boost the body's endogenous antioxidant defense system, inhibit lipid peroxidation, and reduce neuronal oxidative damage induced by reactive oxygen species. Regarding neuroinflammation, Gynostemma pentaphyllum extract moderately modulates the activity of the NF-κB pro-inflammatory pathway, lowers the secretion of pro-inflammatory cytokines, and alleviates neuroinflammatory burden triggered by overactivated microglia.

 

In preserving neuronal survival and homeostasis, it activates the PI3K/Akt signaling pathway and downregulates pro-apoptotic factors to help reduce neuronal apoptosis. Meanwhile, it regulates the mTOR/ULK1 pathway to prevent aberrant excessive autophagy in hippocampal neurons and maintain normal cellular physiological balance. Furthermore, Gynostemma pentaphyllum extract modulates acetylcholinesterase activity, supports BDNF signaling expression and optimizes mitochondrial function. It helps sustain synaptic plasticity and brain cell energy metabolism, thereby benefiting cognitive functions associated with learning and memory.

Berberine, quercetin and Gynostemma pentaphyllum extract have demonstrated anti-inflammatory and antioxidant potential in scientific research. They can help support glucose and lipid metabolism as well as cardiovascular health, and are often combined in metabolic health dietary formulations to achieve complementary action targets. However, they differ greatly in chemical classification and functional focus. Berberine is an isoquinoline alkaloid extracted from Coptis chinensis and Phellodendron chinense, with low oral bioavailability. Studies indicate it helps modulate gut microbiota and support intestinal microecology. It assists in improving insulin sensitivity and lipid profiles by activating the AMPK pathway, and has been traditionally used to support intestinal comfort.

Quercetin is a flavonol naturally found in common foods including onions, apples and berries. As a broad-spectrum antioxidant monomer, it aids free radical scavenging, mitigates inflammatory responses by regulating the NF-κB signaling pathway, preserves vascular endothelial health and stabilizes mast cells.

The marker active constituents of Gynostemma pentaphyllum extract are gypenosides, alongside flavonoids including quercetin. From an herbal application perspective, it supports spleen nourishment and heart calming. Its gypenosides help regulate blood lipids, protect the liver, relieve fatigue and maintain normal immune function. Unlike berberine, Gynostemma pentaphyllum extract does not exert strong intestinal bacteriostatic effects; it delivers gentle systemic conditioning through synergistic actions of multiple active ingredients.

Gynostemma Pentaphyllum Supplement

Gynostemma pentaphyllum extract is a core raw material in the global botanical dietary supplement segment. It is commonly formulated into capsules, tablets and powders. Relying on the biological activities of gypenosides including lipid metabolism regulation, antioxidant, immune modulation and anti-stress effects, it is marketed for cardiovascular support, metabolic management, anti-fatigue and liver care. The mainstream product specifications are 40%~98% total gypenosides.

Gynostemma Extract in Functional Foods and Beverages

Gynostemma pentaphyllum extract, as a natural functional ingredient, is widely incorporated into herbal teas, solid beverages, sports drinks, compressed candies, baked pastries and other products. It features a herbal flavour and mild sweetness, which helps optimise formulation taste and reduce the use of artificial sweeteners while delivering endogenous antioxidant activity. The water-soluble powder is suitable for continuous industrial production. Demand is steadily growing in low-sugar and organic health foods, with dosage flexibly adjusted according to liquid or solid product forms.

Healthkintai^® provides Gynostemma pentaphyllum extract gypenosides powder with various specifications. The gypenosides content ranges from 5% to 98%, suitable for diverse formulation and product development requirements. We own our manufacturing plant equipped with clean production workshops. Production is fully managed in compliance with GMP standards, with strict quality control at every stage from raw material feeding to finished product delivery.

Our company holds complete foreign trade qualifications. We can supply full documents such as COA and MSDS for each corresponding batch upon shipment. Indicators including heavy metals, microorganisms and total aerobic plate count all meet relevant standards. The product features stable and reliable quality for your procurement.

Please share your formulation and application requirements. Sample testing is available, and the minimum order quantity is 1 kg. We look forward to discussing cooperation with you. Contact us at health@kintaibio.com.

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