5-Aminolevulinic Acid Phosphate Powder Manufacturers/Suppliers
Healthkintai® is a manufacturer and supplier of 5-Aminolevulinic Acid Phosphate. 5-ALA phosphate is a high-purity, highly stable bioactive amino acid derivative. As the phosphate form of 5-aminolevulinic acid, this product significantly improves the stability and water solubility of the compound while maintaining its core bioactivity, making it an important functional ingredient in dietary supplements, functional foods, pharmaceuticals, and agriculture. Buy 99% pure 5-ALA powder,contact us at info@kintabio.com.
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Product Name |
Specification |
Test Method |
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5-ALA phosphate |
99%5-ALA phosphate |
HPLC |
What is 5 ala Phosphate mechanism of action?
The core mechanism of action of 5-aminolevulinic acid Phosphate(5-ALA Phosphate) stems from its unique role as the first key precursor in the heme biosynthesis pathway. After entering the cell, 5-ALA is gradually converted into heme by a series of enzymes in the mitochondria. Supplementing with exogenous 5-ALA Powder can effectively increase the rate of intracellular heme synthesis, thereby activating mitochondrial oxidative phosphorylation, enhancing the efficiency of adenosine triphosphate (ATP) production, and improving cellular energy metabolism. This process activates the Nrf2/ARE antioxidant signaling pathway while inhibiting the NF-κB inflammatory signaling pathway, thus enhancing cellular energy supply and exerting multiple biological effects including anti-oxidative stress, anti-inflammatory response, and cell protection.
What's the difference between 5-ALA and 5-ALA Phosphate?
The core difference between 5-ALA and 5-ALA phosphate lies in their chemical form and application: 5-ALA typically refers to its free acid form, which has poor stability and is easily degraded during storage and processing, primarily used in scientific research; while 5-ALA phosphate is a stable salt formed from 5-ALA and phosphoric acid, with a larger molecular weight (5-ALA phosphate is 229.13 g/mol, 5-ALA free acid is 131.13 g/mol), and different CAS numbers (5-ALA phosphate is 868074-65-1, 5-ALA free acid is 106-60-5).
In terms of application, 5-ALA phosphate, with its higher stability, excellent water solubility, and lower gastrointestinal irritation, has become the preferred form in dietary supplements and functional foods, especially suitable for long-term oral administration. In short, 5-ALA phosphate is a "saltification" modified form of 5-ALA, specifically designed to improve product stability and user comfort.
What are 5-aminolevulinic acid phosphate benefits?
5-ALA Anti-Fatigue
5-ALA can significantly improve the body's energy metabolism and exert an anti-fatigue effect. Its mechanism lies in the fact that after entering cells, 5-ALA Powder promotes heme synthesis, thereby enhancing the activity of complexes such as cytochrome c oxidase in the mitochondrial electron transport chain and increasing the efficiency of adenosine triphosphate (ATP) production. Animal experiments have confirmed that long-term oral administration of 5-ALA bulk can significantly restore exercise endurance in fatigue model mice and improve fatigue-induced hypoglycemia. This mechanism is related to promoting fatty acid utilization and activating the norepinephrine neuron system in the frontal cortex. Clinical studies also suggest that wholesale 5-ALA supplementation can alleviate symptoms of chronic physical fatigue in healthy individuals, improve work efficiency, and reduce morning fatigue.
5-ALA for Metabolism
5-ALA has significant potential in regulating glucose and lipid metabolism. Randomized controlled trials have confirmed its efficacy in glycemic control in patients with prediabetes and type 2 diabetes. Its mechanism of action involves multiple levels: 5-ALA powder can upregulate the expression of glucose transporters GLUT1 and GLUT2, promoting glucose uptake and utilization in peripheral tissues; it also activates the AMPK signaling pathway, regulating fatty acid oxidation; furthermore, it can promote energy expenditure by upregulating the expression of coupling proteins UCP1 and UCP2. More importantly, Bulk 5-ALA can improve mitochondrial function, reduce insulin resistance, and has good safety and tolerability when used in combination with oral hypoglycemic agents, with only mild side effects reported.
5 aLA for glioma
The application of 5-aminolevulinic acid (5-ALA) in glioma treatment is primarily as a key adjunct to fluorescence-guided resection (FGR). Its core mechanism lies in the fact that 5-ALA, as a prodrug, causes tumor tissue to emit red fluorescence under blue light excitation at a specific wavelength, thus helping surgeons clearly identify tumor boundaries during surgery. Clinical studies have confirmed that using bulk 5-ALA for fluorescence-guided resection can significantly increase the complete resection rate of high-grade gliomas from approximately 36% to over 65%, and effectively improve patients' progression-free survival and overall survival.
What are 5 aminolevulinic acid uses?
5 aminolevulinic acid supplement
The uses of 5-aminolevulinic acid phosphate (5-ALA phosphate) in the health supplement industry is most mature in the Japanese market, with a wide variety of product forms, mainly covering capsules, tablets, and powders. Blood glucose management was its earliest approved application. Anti-fatigue series is another mainstream category, effectively relieving physical fatigue caused by daily life and work, as well as morning fatigue. Products in the beauty and anti-aging field are formulated with ingredients such as coenzyme Q10, biotin, and vitamin C. Innovative products have also emerged in the field of emotional health, alleviating temporary low mood caused by stress by regulating neurotransmitter levels.
5-Aminolevulinic acid phosphate in functional foods/beverages
5-Aminolevulinic acid phosphate (5-ALA phosphate) has diverse applications in functional foods and beverages. Functional beverages are the fastest-growing category, offering convenient daily intake and primarily targeting office workers and the elderly who are concerned about post-meal blood sugar levels. Gummies are also gaining popularity, claiming to relieve emotional stress and aid glucose metabolism, offering both portability and palatability, making them suitable for younger consumers and those who prefer not to swallow capsules. In the powder sector, the addition of 5-ALA phosphate to protein powders and solid beverages allows for claims such as supporting athletic performance and reducing post-exercise fatigue, meeting the energy recovery needs of fitness enthusiasts.
5-aminolevulinic acid in skincare
5-Alanine aminolevulinic acid phosphate (5-ALA phosphate) is primarily used in skincare products, including day creams, serums, lotions, and masks. In anti-aging products, some day creams claim to utilize sunlight to promote skin regeneration and achieve a skin-renewing effect by identifying and eliminating aging cells. In skin repair and moisturizing products, 5-ALA phosphate helps supply and retain moisture in the skin. Furthermore, bulk 5-ALA phosphate has been studied for its use in improving skin problems such as acne and rosacea, and is often combined with post-medical aesthetic procedures like microneedling and laser treatments to accelerate the skin's re-epithelialization process.
Is 5-ALA phosphate safe?
The oral safety of 5-aminolevulinic acid phosphate (5-ALA phosphate) has been validated by multiple clinical studies. No adverse events related to the investigational compound were observed in healthy subjects; no abnormalities were found in blood biochemistry or urinalysis, with only a mild to moderate, transient increase in serum iron levels. In patients with type 2 diabetes, the incidence of adverse events was not significantly different from the placebo group at daily doses up to 200 mg for 12 weeks. The most common reaction was gastrointestinal symptoms; no hypoglycemic events or significant abnormalities in laboratory parameters were observed. Overall, 5-ALA phosphate demonstrates good safety and tolerability within the recommended dose range.
Where to buy the best 5-ALA phosphate powder?
Choosing our 5-ALA phosphate powder means choosing quality, stability, and professionalism. To ensure long-term storage and processing adaptability, our 5-ALA phosphate maintains its core bioactivity while exhibiting excellent water solubility and thermal stability, easily adaptable to various dosage forms such as capsules, tablets, powders, beverages, and gummies. We have a large-scale production capacity of tens of tons per year, meeting the full lifecycle supply needs of B2B clients from R&D prototyping to commercial mass production. Furthermore, we provide one-stop technical support from formulation design and regulatory compliance to label review, helping clients quickly achieve compliant product launches in the global market. Choose us and let your functional foods or dietary supplements win at the quality starting line. Wholesale 5-ALA phosphate powder,contact us at info@kintaibio.com.
FAQ
Q: What does 5-ALA do?
A: 5-ALA is a naturally occurring compound in the human body, primarily responsible for the synthesis of heme, which in turn supports the function of hemoglobin and mitochondria. Its core benefits include increasing cellular energy (ATP) production, improving blood sugar and lipid metabolism, slowing aging, and aiding in detoxification. In medicine, 5-ALA is also used in photodynamic therapy, where it selectively accumulates in tumor cells and, upon exposure to specific wavelengths of light, produces a killing effect. It is commonly used to treat diseases such as bladder cancer and glioma.
Q: What does 5-ALA taste like?
A: Based on available information, 5-ALA itself is a white to off-white crystalline powder with its "characteristic odor" or "mildly characteristic odor." However, one patient who took 5-ALA liquid before surgery described its taste as "very unpleasant." In summary, this compound may provide an unpleasant and intense taste experience when taken orally, and professional chemical suppliers generally do not recommend its use for flavoring purposes.
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