Galla Chinensis Extract Gallic Acid Powder

Galla Chinensis Extract (Gallic Acid) is a natural polyphenolic raw material derived from gallnuts and obtained through hydrolysis and purification processes. Its principal active component is gallic acid, which delivers favorable free-radical scavenging, antioxidant, antimicrobial-anti-inflammatory, metal-chelating and astringent properties. For cosmetic and skincare applications, this ingredient is frequently incorporated into antioxidant-repair formulations to help counter environmental stress triggered by free radicals and soothe skin conditions. In the food sector, it functions as a natural antioxidant ingredient primarily for oxidative protection of oil-fat systems, and also serves as a key synthetic intermediate for manufacturing Propyl Gallate (PG). Within pharmaceutical-chemical industries, it acts as a functional chemical intermediate leveraging its antimicrobial and astringent attributes. Furthermore, it is widely adopted in fine chemicals, textile printing-dyeing and tanning-processing industries.

Plant-based extracts represent the core product line of Healthkintai^®. We boast years of practical experience in R&D and production of botanical extracts. Among our offerings, Galla Chinensis Extract Gallic Acid Powder ranks as one of our best-selling raw materials. Our mainstream popular specification is 99% powder. Apart from standard stock specifications, we deliver customized supporting services. Should you have any requirements for project development, please feel free to contact us at health@kintaibio.com and share your formulation parameters, application fields and technical demands. We will work out tailored solutions for your business.

The global gallic acid market maintains steady-growth momentum, mostly produced via hydrolysis of gallnut tannins and segmented into pharmaceutical-grade, food-grade and industrial-grade specifications. Its major end-use sectors include pharmaceutical intermediates, dietary supplements, cosmetic antioxidants, natural food preservatives and fine chemicals. Asia-Pacific serves as the core manufacturing hub with China acting as the world's key supplier exporting substantial volumes to Europe, America and Southeast Asia.

Driven by the clean-label trend, demand for this natural polyphenol ingredient keeps rising, yet the industry is challenged by seasonal raw-material fluctuation of gallnuts which triggers supply and cost volatility. Market competition focuses on purity management, eco-friendly extraction technology and international compliance certification. Pharmaceutical-grade gallic acid delivers higher added-value, and the whole industry will move toward higher refinement and standardization alongside expanding consumption from nutraceutical and personal-care sectors.

Gallic Acid Solubility in Water

Is gallic acid soluble in water? Gallic acid is classified as slightly soluble to sparingly soluble in water and its solubility is highly temperature-sensitive. Gallic acid at room temperature (20 °C), the solubility of anhydrous gallic acid is approximately 1.19 g/100 mL, while its monohydrate exhibits slightly higher solubility at roughly 1.5 g/100 mL. Its solubility rises sharply with increasing water temperature and can reach as high as 33% in boiling water at 100 °C, which makes it readily soluble in hot water but poorly soluble in cold water.

Gallic Acid Solubility in Ethanol

Gallic acid has good solubility in ethanol and falls into the readily-soluble category, with its solubility increasing as temperature rises. Its dissolving capacity is notably superior to that in cold water. At room temperature (approximately 25 °C), 1 g of gallic acid can be fully dissolved in only about 6 mL of ethanol. Expressed as mass fraction, its solubility in ethanol is roughly 16%, equivalent to around 160 g/L.

Gallic Acid Solubility in Methanol

Gallic acid is very freely soluble in methanol, showing the highest solubility among all common solvents. At 25 °C, approximately 28.11 g of gallic acid can be dissolved in 100 g of methanol. When the temperature rises to around 50 °C, the solubility further increases to 30.65 g. Among the four solvents-methanol, ethanol, water and ethyl acetate, the solubility order of gallic acid is methanol > ethanol > water > ethyl acetate, and methanol serves as the optimal solvent.

Gallic acid is a monomeric phenolic acid, also known as free gallic acid. Diglucosyl gallic acid is a glycoside derivative formed by glycosylation modification of gallic acid, with two glucose molecules attached to its molecular structure. Both ingredients share the same gallic-acid parent nucleus and demonstrate research-backed potential for antioxidant effects, free-radical neutralization and modulation of tyrosinase activity.

Their key differences lie in water-solubility properties, skin penetration behavior, irritation profile and mode of action. Gallic acid features relatively higher lipophilicity and prominent biological activity yet poses an elevated risk of skin irritation. After glycosylation modification, diglucosyl gallic acid obtains greatly improved water-solubility and reduced immediate cellular irritation. It acts on the skin via a sustained-release mechanism to deliver mild skin-brightening conditioning effects, making it a widely-used modified active ingredient in skincare formulations.

Gallic Acid Antimicrobial Activity

Gallic acid is a natural polyphenolic compound widely found in numerous plants and exhibits broad-spectrum bactericidal and fungicidal properties against a variety of bacteria and fungi. In terms of direct bactericidal effects, gallic acid damages the structure of bacterial cell walls and cell membranes and increases membrane permeability. This triggers leakage of key intracellular components including nucleic acids and proteins, and eventually leads to bacterial cell lysis. With respect to bacterial biofilms, gallic acid can inhibit biofilm formation as well as degrade pre-formed mature biofilms. Its underlying mechanism is mainly attributed to the down-regulation of sarA, icaA and icaD gene expression, which reduces production of intercellular polysaccharide adhesin and weakens bacterial adhesion and colonization capacity. Furthermore, gallic acid inhibits bacterial efflux pump systems, helping antibiotics maintain higher effective concentrations inside bacterial cells. When combined with cephalosporins and tetracyclines, it delivers prominent synergistic antibacterial effects.

Gallic Acid Antioxidant

The antioxidant capacity of gallic acid primarily stems from three phenolic hydroxyl groups on its benzene ring, among which the vicinal tri-hydroxyl structure plays the most critical role. This structure donates hydrogen atoms or electrons to hydroxyl radicals, peroxyl radicals and DPPH radicals, and converts itself into relatively stable phenoxyl radicals. With the resonance effect of the benzene ring and intramolecular hydrogen bonds formed by adjacent hydroxyl groups, the stability of radical intermediates is further enhanced, thus terminating the free-radical chain oxidation process. In addition, gallic acid is capable of chelating transition-metal ions such as ferrous ions and cuprous ions, reducing the activity of the Fenton reaction and inhibiting metal-mediated lipid peroxidation. It also functions to regenerate endogenous antioxidants including vitamin C and vitamin E.

Gallic Acid Allergy

Available studies indicate that gallic acid exerts potential anti-allergic soothing effects mainly through two pathways:

Inhibition of allergic-inflammatory release: it modulates cellular signals to reduce mast-cell activation and histamine release, and suppresses the production of inflammatory factors. Its relevant effect is comparable to cromolyn sodium.

Balancing systemic immune status: animal experiments confirm that gallic acid modulates T-cell immune responses, ameliorates mucosal inflammation and cellular infiltration caused by allergic rhinitis, and reduces allergy-related markers. It also shows potential for alleviating skin inflammation associated with atopic dermatitis.

Gallic Acid for Skin

Gallic acid for skin whitening

Gallic acid is a highly effective antioxidant. It helps inhibit tyrosinase activity and blocks key biochemical pathways for melanin production. It alleviates UV-induced oxidative stress damage and improves dull, yellowish skin tone caused by photodamage for gradual enhancement of overall skin translucency. Please note that this ingredient delivers skin-toning effects rather than skin bleaching, and improvements require consistent use.

Gallic acid for acne

With its natural antioxidant and antibacterial properties, gallic acid restrains over-proliferation of acne-causing microbes and calves local skin inflammatory responses. For oily skin types, it eases redness and discomfort triggered by oxidized sebum and assists in mitigating visible signs of inflammatory blemishes. As a cosmetic raw material, it is not a substitute for medication. Severe acne should be treated by a qualified dermatologist.

Gallic acid for dark spots

Prolonged UV exposure triggers excessive free-radical generation, accelerating pigment deposition and the formation of pigmented spots. Through antioxidant action, gallic acid reduces continuous free-radical stimulation to melanocytes, slows further spot darkening and inhibits pigment transportation to the stratum corneum. This ingredient mainly prevents spot progression and fades superficial pigmentation. Deep-seated stubborn spots can hardly be completely eliminated by topical skincare alone and demand long-term skin care routines.

Gallic Acid for Hair

Gallic acid is a natural polyphenol-active ingredient. It helps inhibit 5α-reductase and reduce DHT levels. It soothes scalp inflammation triggered by NF-κB pathway activation and alleviates scalp discomfort caused by oxidative stress. It improves redness, itchiness and excessive sebum secretion of the scalp, and eases pressure on hair follicles under seborrheic conditions. Meanwhile, this ingredient scavenges free radicals, boosts the scalp's antioxidant defense system, maintains a healthy follicular micro-environment and lessens damage to hair roots from external oxidation factors.

Gallic Acid for Weight Loss

Gallic acid is a plant-derived natural polyphenol. It may help inhibit the proliferation and differentiation of adipocytes, modulate the body's lipogenic signaling pathways and reduce excessive lipid buildup. Meanwhile, it assists in regulating oxidative stress and alleviating chronic low-grade inflammation to improve overall metabolic status and offer supportive benefits for weight management. Please note that this ingredient delivers no direct fat-burning or rapid weight-loss effect. It only serves as a metabolic aid from a dietary perspective. Healthy weight management requires proper calorie control and regular physical activity and cannot replace a balanced diet and healthy lifestyle.

Ellagic acid and gallic acid are both plant-polyphenol active substances derived from the hydrolyzable tannin family. Within natural botanical raw-material systems, they share close biochemical relationships: gallic acid serves as the basic monomer molecule, while ellagic acid is formed via oxidative coupling and ring-closure reaction of two gallic-acid molecules.

As an active component with lower molecular weight, gallic acid delivers favourable skin-penetrating capacity. Its key functional properties include effective scavenging of excess free radicals, inhibition of tyrosinase catalytic reaction, and mitigation of oxidation-triggered skin inflammation through modulation of the NF-κB signaling pathway, with a focus on instant antioxidant activity and soothing repair. With a comparatively higher molecular weight, ellagic acid demonstrates better chemical stability yet limited transdermal permeability. It does not primarily target melanin synthesis; its core value lies in suppressing melanin-transport mechanisms and hindering the migration and spread of mature melanin to epidermal keratinocytes.

Natural plant extracts such as pomegranate peel and rosemary frequently contain both actives. When combined, they build a synergistic skin-brightening system: gallic acid works at the source to interfere with melanin production, whereas ellagic acid blocks outward pigment translocation. This combination offsets the inherent limitations of each single ingredient and delivers multiple skin benefits covering anti-oxidation, anti-inflammation and pigment conditioning.

Gallic Acid Medicinal Uses

Gallic acid possesses stable antioxidant, antibacterial, anti-inflammatory and wound astringent properties, serving as an important synthetic intermediate and standard reference material in the global pharmaceutical and chemical industry. In the pharmaceutical industrial chain, it is rarely directly formulated into oral finished medicines and is mainly used as a core raw material for synthesizing various gallate derivatives, which are widely applied in the production of pharmaceutical formulation materials.

Gallic Acid Cosmestic Uses

Derived from natural plant sources, gallic acid is widely listed as a qualified cosmetic raw material worldwide and serves as a commonly used functional active ingredient in skincare products. In product formulations, it acts not only as an effective skincare active substance but also as a formulation stabilizer that slows down the oxidative deterioration of oils and active components, thereby extending the shelf life of cosmetic products. In commercial applications, its dosage must be strictly controlled to avoid skin irritation caused by its acidity, ensuring compliance with cosmetic ingredient regulations in multiple countries.

Healthkintai^® is a specialized enterprise focusing on the R&D, production and supply of cosmetic raw materials. With years-long expertise in natural plant extraction, we deliver safe, stable and high-purity key ingredients as well as one-stop technical services for global cosmetic and personal-care brands. Our best-selling item is 99% Chinese gallnuts gallic acid anhydrous powder. Featuring high purity, excellent batch-to-batch consistency and favorable bioavailability, it is widely adopted in functional skincare formulations for whitening, antioxidant, astringent and soothing purposes and well-recognized by customers worldwide.

We also supply monohydrate gallic acid and a portfolio of derivative products including digalloyl glucose and propyl gallate to cater for diverse formulation systems and application scenarios and support customers to build flexible product lines. Following GMP manufacturing specifications, we exercises full-process control ranging from raw material sourcing, extraction processing to finished-product packaging. Microorganism and heavy-metal levels comply with industry standards to guarantee safety and quality consistency across all batches.

Fully certified with complete documentation system, we can provide all supporting documents required for cosmetic registration and import-export customs clearance to streamline your procurement and business cooperation. Adhering to the principle of quality-oriented and service-driven, we sincerely welcome global partners for business discussions. Feel free to contact us at health@kintaibio.com for samples, technical datasheets and detailed quotations. We looks forward to creating mutual value together with you.

Hot Tags: galla chinensis extract gallic acid powder, China galla chinensis extract gallic acid powder manufacturers, suppliers, factory