Dihydromyricetin for hangovers​：How does DHM work？

Dihydromyricetin (3,5,7,3',4',5'-hexahydroxy-2,3-dihydroflavonol, dihydromyricetin, DMY) is a naturally occurring flavonoid compound first extracted from the leaves of the Ampelopsis neemosa grape in 1940. It is widely found in Ampelopsis neemosa plants of the Ampelopsis family, and its content in vine tea can reach up to 30%. It exhibits anti-inflammatory, antioxidant, hepatoprotective, blood sugar and lipid-regulating, and anti-tumor properties.

Alcohol and its metabolites are toxic to liver cells, disrupting liver fat metabolism and causing fat accumulation, which in turn triggers hepatitis and, in turn, induces fatty liver disease, fibrosis, and cirrhosis, leading to irreversible liver damage and multiple complications. Natural products such as flavonoids possess significant antioxidant and anti-inflammatory activities, providing a rich source of compounds for screening lead compounds for anti-alcoholic liver injury.

Dihydromyricetin has strong antioxidant activity, capable of scavenging free radicals and repairing oxidative stress damage. Its scavenging rate for the stable free radical DPPH reaches 73.3% to 91.5%, and its scavenging effect on superoxide radicals is even stronger. A series of reactions caused by a disruption in the homeostasis of oxygen free radical reactions and lipid peroxidation can damage biological membranes. Dihydromyricetin inhibits lipid peroxidation by complexing Fe2+ and preventing linoleic acid peroxidation. Differential scanning calorimetry results demonstrate that dihydromyricetin's antioxidant activity is superior to that of synthetic antioxidants.

Malondialdehyde (MDA) is a cytotoxic end product of lipid peroxidation. Experimental results show that dihydromyricetin effectively inhibits the production of MDA in homogenates of heart, liver, brain, and other tissues, as well as in mitochondria, induced by various systems. Enzymes that scavenge free radicals in the body include superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). The results of the H 2 O 2 -induced lipid peroxidation damage model of porcine renal epithelial cell line PK-15 showed that the amount of MDA produced in the model was significantly reduced after pre-protection with dihydromyricetin, which can effectively protect cell DNA from oxidative damage.

(Reference: Protective effects of dihydromyricetin against alcoholic liver injurybased on a zebrafish（Danio rerio）model,SUN Xinna 1，2，YANG Jiaqi1，2，QIN Xueting 1，2，ZHANG Qian1，2，CHEN Liang 1，2，JIN Shanfeng 1，2，XIA Qing1，3，* )

• Pre- and post-alcohol protection: Taking it before or during drinking can pre-condition the liver, enhancing its ability to metabolize alcohol and resist damage.
• Post-alcohol recovery: Taking it after drinking can accelerate the removal of residual alcohol and acetaldehyde from the body, alleviating hangover symptoms such as headaches, nausea, and fatigue.​​​​​​​
• Long-term protection: For those who frequently consume alcohol for social events, moderate long-term supplementation may help prevent the onset and progression of alcoholic liver disease.​​​​​​​

1. Oral Liquid/Drink

This is a very classic and effective form.

a. Product Form: Small bottles of oral liquid, functional drink.

b. Advantages:

• Fast onset of action: Liquid forms do not require disintegration and dissolution, and are generally absorbed faster than solid dosage forms, making them suitable for immediate relief during or after drinking.
• Convenience: Easy to drink if the taste is adjusted properly.
• Flexible Combination: Can be easily combined with other liver-protecting and hangover-relief ingredients such as Pueraria lobata, Hovenia dulcis, honey, and Vitamins B/C to create complex formulas.

c. Market Positioning: Quick hangover relief, companion to banquets.

2. Tablets/Capsules

This is the most common form of health supplement, with mature technology.

a. Product Form: Compressed candy, hard capsules, soft capsules.

b. Advantages:

• Precise dosage: Each tablet/capsule contains a fixed amount of dihydromyricetin, allowing for easy quantitative intake.
• Portability: Easy to carry and discreet.
• Good stability: Resists moisture absorption and deterioration, with a long shelf life. Tasteless: The capsule shell effectively masks any unpleasant taste.

c. Market Positioning: Daily liver health and wellness, preventive measures. Suitable for pre-emptive use or as a dietary supplement for long-term maintenance.

3. Instant Powder/Solid Drink

Combines the drinkability of oral liquids with the portability of tablets.

a. Product Form: Individually packaged powder strips, taken with water.

b. Advantages:

• Fast absorption: Dissolves and then drinks, with an absorption rate intermediate between that of oral liquids and tablets.
• Portability and taste: Portability is excellent, and flavoring can be used to enhance the taste.
• Diverse Applications: Can be poured into a glass or bottle for drinking, making it relatively discreet.

c. Market Positioning: Young, fashionable individuals, and social gatherings.

4. Chewable Tablets

A form factor with a superior user experience.

a. Product Form: Similar to chewing gum or chewable vitamin tablets.

b. Advantages:

• Convenient: No water required, can be taken anytime, anywhere.
• Enjoyable Experience: The excellent taste can alleviate oral discomfort after drinking. Rapid absorption: Partially absorbed through the oral and gastric mucosa.

c. Market Positioning:Users seeking convenience and taste, and those seeking breath freshening after drinking.

5. Gummy Candies/Jelly Candies

The "snack-like" health supplement format has become extremely popular in recent years.

a. Product Form: Chewy pectin or gelatin gummies.

b. Advantages:

• Excellent user experience: Enjoying candy without the burden of taking medication is especially popular among young people and women.
• Delicious: Available in a variety of fruit flavors.
• Shareable: Easy to share in social settings.

c. Market Positioning:Young consumers, the female market, and entry-level health supplements.

 The dihydromyricetin powder produced by Kintai is extracted from vine tea, with 98% dihydromyricetin, 30% water-soluble dihydromyricetin and 85% water-soluble dihydromyricetin. Our DHM powder has passed heavy metal, aflatoxin, pesticide residue and PAHS tests, providing customers with high-quality and safe products. It has a broad application prospect in the field of food, medicine and health care products. Please feel free to contact us at health@kintaibio.com.