Urolithin A Powder

Urolithin A (3,8-dihydroxybenzo[c]chromen-6-one), also know as UA or Uro-A, is a naturally occurring bioactive metabolite generated when ellagitannins from pomegranates, raspberries, nuts and other foods are broken down by gut bacteria. As a potent mitophagy activator, it facilitates the clearance of damaged mitochondria to restore cellular energy metabolism, alongside offering antioxidant and anti-inflammatory benefits. Only around 40% of people possess the gut microbiome required to efficiently convert dietary ellagitannins into Urolithin A, making purified supplemental Urolithin A a preferred alternative. Commercially, Urolithin A is widely incorporated into dietary supplements, functional food formulations and cosmetic products.

Market analysis shows the global Urolithin A market reached approximately USD 1.14 billion in 2025, with projections to rise to USD 2.55 billion by 2032, representing a compound annual growth rate above 12%. Healthkintai^® provides bulk 98% high-purity Urolithin A powder. Liposomal Urolithin A is available as an alternative. Liposomal encapsulation enhances the ingredient's water solubility and bioavailability to suit various formulation demands. Detailed parameters for different specifications are listed in the table below. Please contact us at health@kintaibio.com for samples, technical data sheets and up-to-date pricing.

In the USA

Synthetic Urolithin A received the FDA GRAS No Objection Letter in 2018, allowing its incorporation into dietary supplements and designated processed foods such as nutrition bars, yogurt, cereals, and protein drinks. The maximum daily intake for adults is 1000 mg, with a per-serving limit of 500 mg in solid foods and up to 1000 mg in beverages. Urolithin A has not filed an independent New Dietary Ingredient (NDI) notification, and its development for pharmaceutical use is still under clinical investigation.

In Australia

Australia's TGA issued the compositional guideline for urolithin A with an effective date of 1 October 2025. Synthetic urolithin A is approved solely for listed medicines (nutritional supplements / adjunct medicines) and is prohibited from use as an ingredient in general foods. Relevant products are required to complete TGA-listed medicine notification before commercialization.

Urolithin A for Muscle Health

Urolithin A supports muscle health primarily by re-activating age-impaired mitophagy. As a high-energy-demanding tissue, muscle cell performance heavily relies on functional mitochondria. Accumulation of damaged mitochondria reduces cellular energy production and compromises overall muscle function.

Uro-A precisely triggers the PINK1/Parkin signaling pathway to tag dysfunctional mitochondria for degradation and restore impaired mitophagy clearance, effectively replacing aged mitochondria. This cellular renewal supports more efficient energy output from remaining mitochondria. Additionally, it lowers myostatin levels to slow muscle-protein breakdown and improves glucose utilization within muscle cells to optimize fuel supply for muscle tissue.

Urolithin A for Weight Loss

UA triggers mitophagy to clear damaged mitochondria, upregulates the SIRT1-PGC-1α pathway to boost mitochondrial biogenesis, supports the browning of white adipose tissue to raise whole-body energy expenditure, inhibits adipocyte differentiation and lipid accumulation, eases metabolic disruption driven by low-grade chronic inflammation, improves insulin sensitivity and helps reduce visceral-fat buildup for supportive weight-management benefits.

It is not a fat-burning miracle compound; its metabolic benefits depend on an individual's gut-microbiome profile, and optimal outcomes require paired dietary and lifestyle intervention. Large-scale human clinical data remain limited.

Urolithin A for Skincare

Uro-A activates autophagy in skin cells to clear aged and damaged mitochondria as well as oxidatively-damaged proteins, reducing reactive oxygen species buildup to ease oxidative stress and cutaneous inflammation. It may help improve fine lines, skin laxity and dull complexion triggered by photoaging.

Meanwhile, it modulates pro-inflammatory factors to alleviate persistent low-grade skin inflammation, supports healthy skin barrier function and relieves sensitive and rough skin texture. It also reduces the formation and accumulation of advanced glycation end-products (AGEs), mitigating yellowish skin tone and diminished elasticity caused by collagen glycation cross-linking. It helps slow cutaneous aging and delivers skin benefits including firmer, brighter complexion and stabilized skin condition.

Urolithin A Supplements

Urolithin A is a popular raw material for cellular anti-aging worldwide, with hard capsules, powders and stick-pack powders as its main product forms. Targeting middle-aged and elderly populations as well as sub-health anti-aging consumers, it is frequently compounded with PQQ, Coenzyme Q10, phosphatidylserine, resveratrol, and NAD+ precursors (NMN), covering segmented areas including muscle maintenance, mitochondrial support, immunosenescence modulation and metabolic support. It has obtained GRAS safety qualification in the United States, and mature overseas brands have achieved its commercialization.

Urolithin A Skincare Products

Urolithin A is positioned as a cellular-level anti-aging skincare ingredient, widely used in high-end functional skincare products such as anti-wrinkle serums, firming creams and repairing face masks. When applied topically, it acts on the mitochondria of skin cells, eliminating damaged mitochondria in the skin, exerting antioxidant effects, inhibiting local skin inflammation, boosting collagen synthesis, and improving fine lines and skin sagging. It also repairs the skin barrier and reduces transepidermal water loss (TEWL). Transdermal absorption efficiency is a key consideration in formula design, with a typical usage concentration of 0.5-1%. It can be combined with other anti-aging ingredients, including hydroxypropyl tetrahydropyrantriol (Pro-Xylane), peptides and ergothioneine.

As a dietary supplement, Urolithin-A is recommended to start at 250 mg per day for daily health maintenance; 500 mg per day has been used for short-term purposes in some clinical trials. Doses above 1000 mg per day lack sufficient human data and are not advised for long-term self-administration. A distinction should be made between pure Urolithin-A and ellagic acid or pomegranate-derived precursors, which require gut microbiota for conversion.

This ingredient is generally well-tolerated, though high doses may trigger gastrointestinal reactions such as bloating and loose stools. Administration with meals is suggested, and dosage should be reduced promptly if discomfort occurs. Pregnant or lactating women and individuals with liver or kidney abnormalities shall consult a physician. No official therapeutic dosage standard is currently available.

Urolithin A is a dietary-supplement ingredient associated with mitophagy. The optimal time for intake is after breakfast or lunch. Fats contained in meals help boost the absorption rate of lipophilic Urolithin A. It is not recommended to take it on an empty stomach, as this may cause mild gastrointestinal discomfort. Stick to a fixed daily time for administration; consistent daily intake matters more than precise timing for sustained activation of mitophagy.

Can Urolithin A Cause Insomnia?

UA itself is not a central nervous system stimulant and does not directly cause insomnia. However, some users report improved energy levels and metabolism after taking it. When taken in the evening or before bedtime, a small number of sensitive individuals may experience difficulty falling asleep or lighter sleep. Therefore, it is recommended to take it after breakfast or lunch and avoid evening hours to reduce the possibility of sleep disruption. Limited clinical evidence indicates that insomnia is a rare but real side-effect of Uro-A. In one clinical trial involving 26 participants, 2 subjects (approximately 7.7%) reported insomnia episodes. If you suffer from insomnia after supplementation, consider adjusting the dosage or discontinuing use and consult a physician.

Healthkintai^® is deeply engaged in the anti-aging sector, focusing on the R&D, production and technical implementation of active raw materials for dietary supplements and cosmetics. Our flagship product is high-purity Urolithin A powder with a purity of 98-99%, suitable for a wide range of applications including oral anti-aging dietary supplements and anti-aging skincare raw materials. Liposomal-formulated variants are also available for your selection.

Equipped with a professional in-house R&D team and clean standardized production workshops, we are capable of fully addressing your project requirements. We provide formula references, product-selection advice and technical communication, and deliver tailored raw-material solutions based on your finished-product positioning and formulation system. Drawing on years of hands-on international trade experience, we can supply a full set of documentation including COA, TDS, SDS and other export-required customs-clearance documents.

Please feel free to contact us at health@kintaibio.com for sample discussion and bulk-order inquiries.

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