Sanguinarine Powder

Sanguinarine Powder is a natural botanical extract derived from plants of the Macleaya cordata genus, with CAS number 2447 - 54 - 3. It is a bioactive alkaloid compound that has garnered significant attention in various industries.

Healthkintai^® stands as a leading producer of Macleaya Cordata Extract 60% total alkaloids( (Sanguinarine>40%,chelerythrine>15%). Through advanced extraction and purification technologies, we deliver pharmaceutical-grade quality, with the key bioactive compound Sanguinarine maintained in its core form, ensuring high bioavailability for diverse applications. Please feel free to contact us at info@kintaibio.com.

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To ensure the quality of our 40% sanguisorbin product's raw materials, we have established a very strict and traceable management system. We only use raw materials grown by ourselves, and these bourbons all come from designated planting bases that meet GACP standards, ensuring the purity and genetic stability of the plants from the source. The harvesting time is also carefully planned, usually selected during the fruiting period or the most vigorous stage of vegetative growth, because extensive practice has proven that at this time, the content of benzyl isoquinoline alkaloids in the plants, especially the sanguisorbin and celandine we need, is at its highest.

Physical and Chemical Properties of Macleaya cordata Extract

Sanguinarine is a benzophenanthridine alkaloid with a complex mechanism of action and multi-target properties. Its core function lies in its ability to broadly interfere with key intracellular biological processes.

It interferes with the cell cycle and DNA function. Sanguinarine can embed itself in the DNA double helix, forming a Sanguinarine-DNA complex. This not only directly inhibits DNA replication and transcription but also induces DNA damage, leading to cell cycle arrest, especially in the G2/M phase, thereby inhibiting cell proliferation. Inducing programmed cell death is one of its most significant characteristics. Sanguisorbin can induce apoptosis through multiple pathways. In the mitochondrial pathway, it causes mitochondrial membrane potential collapse, releasing cytochrome C, which in turn activates the caspase cascade.

Sanguinarine exerts its powerful antibacterial, anti-inflammatory, and anti-proliferative effects through multiple molecular pathways, including direct action on DNA, induction of oxidative stress and apoptosis, and inhibition of key enzyme activity.

Sanguinarine for Animal Feed Additives

This is currently the most important and mature application area for sanguinarine. As a natural plant extract, it is widely used as a green feed additive in livestock production.

With its powerful broad-spectrum antibacterial (especially effective against Gram-negative bacteria) and anti-inflammatory properties, sanguinarine can effectively prevent and treat intestinal diseases in livestock and poultry, improve intestinal health, and thus largely replace growth-promoting antibiotics. It can improve feed conversion rate, promote nutrient digestion and absorption, thereby improving the daily weight gain and overall production performance of animals such as pigs and chickens. By regulating the balance of intestinal flora and inhibiting inflammatory responses, sanguinarine helps enhance the non-specific immunity of animals and reduce the incidence of disease.

Sanguinarine For Oral Care Products

Sanguinarine is one of the earliest and most widely used applications, mainly utilizing its antibacterial and anti-inflammatory properties. It can effectively combat oral pathogens (such as streptococci) that cause dental plaque and gingivitis. By controlling plaque and reducing inflammation, it is added to products such as Sanguinarine toothpaste and Sanguinarine mouthwash for the prevention and treatment of gingivitis and periodontal disease.

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Sanguisorbine requires strict dosage control during application; otherwise, it may cause a series of toxic side effects. Its core toxic mechanism lies in its ability to effectively inhibit Na+/K+-ATPase (sodium-potassium pump) on the cell membrane, thereby disrupting the normal ion gradient inside and outside the cell, leading to severe cellular dysfunction. Specifically, local contact can irritate the skin and mucous membranes; oral overdose can cause severe gastrointestinal reactions such as nausea, vomiting, abdominal pain, and diarrhea. If the toxin is absorbed into the systemic circulation, it can produce more severe systemic poisoning symptoms, including respiratory distress, arrhythmia, hypotension, and even life-threatening conditions due to respiratory paralysis. Therefore, although it has applications in animal feed and oral care, its potential toxicity must be given high priority and strictly controlled.

Our products hold international quality system certifications such as GMP, ISO9001:2015, ISO22000:2018, HACCP, and HALAL. Every batch of products you receive meets international standards for heavy metals, microbial residues, and the content of key active ingredients (such as sanguisorbin), ensuring stable and reliable quality. Furthermore, we offer professional customization services. Whether it's adjusting the total alkaloid content ratio to suit your needs (e.g., a specific concentration of sanguisorbin to chelidonine), or adapting different dosage forms and carriers, we can provide you with a customized solution.

If you require Sanguisorbine powder, please feel free to contact us at info@kintaibio.com.

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